Can insulin signaling pathways be targeted to transport Aβ out of the brain?

ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier

(2018) Tuan Minh Do et al.   JOURNAL OF ALZHEIMERS DISEASE

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans

(2015) Sofiya Gancheva et al.   DIABETES

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

The benefit of docosahexaenoic acid for the adult brain in aging and dementia

(2015) Norman Salem et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults

(2014) Scott Nugent et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

(2014) Sophie Stukas et al.   Cell Metabolism

The Role of Neuronal Insulin/Insulin-Like Growth Factor-1 Signaling for the Pathogenesis of Alzheimer’s Disease: Possible Therapeutic Implications

(2014) Johanna Zemva et al.   CNS & Neurological Disorders-Drug Targets

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Insulin Reverses the High-Fat Diet-Induced Increase in Brain A  and Improves Memory in an Animal Model of Alzheimer Disease

(2014) M. Vandal et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations

(2014) Satya Dash et al.   DIABETES

Cerebrospinal fluid levels of Alzheimer’s disease biomarkers in middle-aged patients with type 1 diabetes

(2014) D. Margriet Ouwens et al.   DIABETOLOGIA

Methylene Blue Modulates β-Secretase, Reverses Cerebral Amyloidosis, and Improves Cognition in Transgenic Mice

(2014) Takashi Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral Perfusion in Insulin Resistance and Type 2 Diabetes

(2014) Henry Rusinek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats

(2014) Yan-Na Sun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

(2014) Hongmei Li et al.   Molecular Neurodegeneration

Aging-related differences in cerebral capillary blood flow in anesthetized rats

(2014) Michèle Desjardins et al.   NEUROBIOLOGY OF AGING

Dietary fat composition and dementia risk

(2014) Martha Clare Morris et al.   NEUROBIOLOGY OF AGING

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

The Relevance of Beta-Amyloid on Markers of Alzheimer’s Disease in Clinically Normal Individuals and Factors That Influence These Associations

(2014) Elizabeth C. Mormino   NEUROPSYCHOLOGY REVIEW

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice

(2014) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

New Therapeutic Approaches for Alzheimer’s Disease and Cerebral Amyloid Angiopathy

(2014) Satoshi Saito et al.   Frontiers in Aging Neuroscience

Accuracy of Brain Amyloid Detection in Clinical Practice Using Cerebrospinal Fluid β-Amyloid 42

(2014) Sebastian Palmqvist et al.   JAMA Neurology

Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances

(2014) Li Liu et al.   Frontiers in Pharmacology

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

(2014) Gary P Morris et al.   Acta Neuropathologica Communications

Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

(2013) Josephine M. Forbes et al.   AMINO ACIDS

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Assessment of dynamic cerebral autoregulation and cerebrovascular CO2reactivity in ageing by measurements of cerebral blood flow and cortical oxygenation

(2013) Madelijn H. Oudegeest-Sander et al.   EXPERIMENTAL PHYSIOLOGY

Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation

(2013) Thomas M. Schilling et al.   HUMAN BRAIN MAPPING

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque

(2013) Jason P. Holland et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Reduction in DHA transport to the brain of mice expressing humanAPOE4compared toAPOE2

(2013) Milène Vandal et al.   JOURNAL OF NEUROCHEMISTRY

Diabetes Augments In Vivo Microvascular Blood Flow Dynamics after Stroke

(2013) K. A. Tennant et al.   JOURNAL OF NEUROSCIENCE

2012: A watershed year for Alzheimer’s disease research

(2013) M. Grundman et al.   Journal of Nutrition Health & Aging

Physiology of Blood–Brain Interfaces in Relation to Brain Disposition of Small Compounds and Macromolecules

(2013) N. Strazielle et al.   MOLECULAR PHARMACEUTICS

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Altered Brain Uptake of Therapeutics in a Triple Transgenic Mouse Model of Alzheimer’s Disease

(2013) Dharmini C. Mehta et al.   PHARMACEUTICAL RESEARCH

Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2013) Masato Maesako et al.   PLoS One

Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease

(2013) Anna M. Barron et al.   PLoS One

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline

(2013) Marie Hennebelle et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers

(2013) R. Potter et al.   Science Translational Medicine

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

(2013) Jean-Philippe Michaud et al.   Cell Reports

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease

(2013) Gaël Chételat et al.   NeuroImage-Clinical

The influence of insulin infusion on the metabolism of amyloid β peptides in plasma

(2012) Monika Karczewska-Kupczewska et al.   Alzheimers & Dementia

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

(2012) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

(2012) Vinay Bhaskar et al.   DIABETES

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

(2012) S. M. Son et al.   DIABETES

Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells

(2012) Giuseppe Pandini et al.   ENDOCRINOLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes

(2012) Manon Brundel et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Cognitive reserve in ageing and Alzheimer's disease

(2012) Yaakov Stern   LANCET NEUROLOGY

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

(2012) Jacob M Basak et al.   Molecular Neurodegeneration

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Immunotherapy for Alzheimer disease—the challenge of adverse effects

(2012) Yu-Hui Liu et al.   Nature Reviews Neurology

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Adhesion Molecules, Altered Vasoreactivity, and Brain Atrophy in Type 2 Diabetes

(2011) V. Novak et al.   DIABETES CARE

Insulin sensitivity of the human brain

(2011) Caroline Ketterer et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Differential effects of intranasal insulin and caffeine on cerebral blood flow

(2011) Yuko Grichisch et al.   HUMAN BRAIN MAPPING

Accumulation of Transactive Response DNA Binding Protein 43 in Mild Cognitive Impairment and Alzheimer Disease

(2011) Cyntia Tremblay et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Sink Hypothesis and Therapeutic Strategies for Attenuating Aβ Levels

(2011) Yan Zhang et al.   NEUROSCIENTIST

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

(2011) Haythum O. Tayeb et al.   PHARMACOLOGY & THERAPEUTICS

Basal Insulin: Physiology, Pharmacology, and Clinical Implications

(2011) Kevin D. Niswender   POSTGRADUATE MEDICINE

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer’s disease

(2010) Ahmadul Kadir et al.   BRAIN

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping

(2010) Saeid Taheri et al.   MAGNETIC RESONANCE IN MEDICINE

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

(2010) Maho Kondo et al.   Molecular Neurodegeneration

Cognition, reserve and amyloid deposition in normal aging

(2009) D.M. Rentz et al.   ANNALS OF NEUROLOGY

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

The role of nutrition in Alzheimer’s disease: epidemiological evidence

(2009) M. C. Morris   EUROPEAN JOURNAL OF NEUROLOGY

P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

(2009) Leon M Tai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrovascular Responses to Insulin in Rats

(2009) Prasad Venkateswera Gurunath Katakam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice

(2009) Hao Hong et al.   NEUROPHARMACOLOGY

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

(2009) Fanchon Bourasset et al.   NEUROPHARMACOLOGY

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance

(2008) Alexander Laatsch et al.   ATHEROSCLEROSIS

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

(2008) Miles C. Miller et al.   BRAIN RESEARCH

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics of A  Turnover and Deposition in Different  -Amyloid Precursor Protein Transgenic Mouse Models Following  -Secretase Inhibition

(2008) D. Abramowski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders

(2008) Manfred Hallschmid et al.   REGULATORY PEPTIDES

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING