Article
Endocrinology & Metabolism
Haishan Huang, Xiaobin Zheng, Xiaoming Wen, Jingyi Zhong, Yanting Zhou, Lingling Xu
Summary: This study found that visceral fat affects insulin secretion and sensitivity in Chinese patients with T2DM, and the impact is more significant in overweight/obese individuals. This suggests that visceral fat plays a crucial role in diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Oana Patricia Zaharia, Dominik Hans Pesta, Pavel Bobrov, Yuliya Kupriyanova, Christian Herder, Yanislava Karusheva, Kalman Bodis, Gidon Josia Boenhof, Johannes Knitza, David Simon, Arnd Kleyer, Jong-Hee Hwang, Karsten Muessig, Dan Ziegler, Volker Burkart, Georg Schett, Michael Roden, Julia Szendroedi
Summary: The study suggests that patients with type 2 diabetes show musculoskeletal impairments and arthritis-related symptoms linked to insulin resistance. Changes in arthritis-related microRNA profiles may be masked by type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yvo J. M. Op den Kamp, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Russell Esterline, Matthijs K. C. Hesselink, Joris Hoeks, Vera B. Schrauwen-Hinderling, Bas Havekes, Jan Oscarsson, Esther Phielix, Patrick Schrauwen
Summary: Treatment with dapagliflozin for 5 weeks resulted in significant metabolic changes resembling caloric restriction, increased fat oxidation, improved insulin sensitivity in the liver and adipose tissue, and enhanced 24-hour energy metabolism.
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Esben S. Lauritzen, Ulla Kampmann, Mette G. B. Pedersen, Lise-Lotte Christensen, Niels Jessen, Niels M-ller, Julie Stoy
Summary: The study investigated the metabolic effects of long-term melatonin treatment in patients with type 2 diabetes, revealing that melatonin treatment decreased insulin sensitivity and increased glucose-stimulated insulin secretion in male patients.
JOURNAL OF PINEAL RESEARCH
(2022)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Article
Engineering, Multidisciplinary
Abhijit Paul, Phonindra Nath Das, Samrat Chatterjee
Summary: Type 2 diabetes is a global health problem caused by the gradual loss of pancreatic beta-cell function. Impaired glucose-stimulated insulin secretion is one of the major causes of beta-cell dysfunction and the development of type 2 diabetes. This study analyzed the potential factors responsible for impaired insulin secretion in insulin resistance and proposed therapeutic strategies for preventing disease progression.
APPLIED MATHEMATICAL MODELLING
(2022)
Review
Endocrinology & Metabolism
Julia H. Goedecke, Amy E. Mendham
Summary: Sub-Saharan Africa has the highest projected rates of increase in type 2 diabetes, with socioenvironmental and lifestyle factors possibly interacting with genetic factors to alter the pathophysiology. The pathophysiology of type 2 diabetes in Black Africans is different from that in their European counterparts. However, current understanding of the disease is largely based on studies involving predominantly White European participants. This review summarizes existing knowledge and data on non-pharmacological interventions exploring the pathophysiology of type 2 diabetes in sub-Saharan Africa, while also highlighting factors that may influence its pathogenesis.
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joseph A. M. J. L. Janssen
Summary: Hyperinsulinemia may be a significant factor in causing obesity, metabolic syndrome, cardiovascular disease, cancer, and premature mortality. Strategies for managing hyperinsulinemia include reducing insulin secretion, increasing hepatic insulin clearance, and maximizing insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Susanna Maria Kemppainen, Lilian Fernandes Silva, Maria Anneli Lankinen, Ursula Schwab, Markku Laakso
Summary: This study investigates the association between physical activity and metabolite signature, revealing that increased physical activity is linked to multiple metabolic pathways and is closely associated with maintaining a healthy lifestyle.
Article
Endocrinology & Metabolism
Roberto Bizzotto, Christopher Jennison, Angus G. Jones, Azra Kurbasic, Andrea Tura, Gwen Kennedy, Jimmy D. Bell, E. Louise Thomas, Gary Frost, Rebeca Eriksen, Robert W. Koivula, Soren Brage, Jane Kaye, Andrew T. Hattersley, Alison Heggie, Donna McEvoy, Leen M. 't Hart, Joline W. Beulens, Petra Elders, Petra B. Musholt, Martin Ridderstrale, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Agnete T. Lundgaard, Henrik S. Thomsen, Federico De Masi, Konstantinos D. Tsirigos, Soren Brunak, Ana Vinuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Ian M. Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Emmanouil Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Paul W. Franks, Mark Walker, Ewan R. Pearson, Andrea Mari
Summary: The study found that deteriorating insulin sensitivity and beta-cell function, increasing insulin clearance, high visceral or liver fat, and worsening lipid profiles are crucial factors in mediating glycemic deterioration in patients with T2D. Stabilizing one of these traits may be relevant in preventing disease progression.
Article
Sport Sciences
Buket Engin, Scott A. Willis, Sundus Malaikah, Jack A. Sargeant, Gregory J. H. Biddle, Cameron Razieh, Stavroula Argyridou, Charlotte L. Edwardson, Charlotte Jelleyman, David J. Stensel, Joseph Henson, Alex V. Rowlands, Melanie J. Davies, Thomas Yates, James A. King
Summary: This study examined the associations between sedentary time, physical activity, and adipose tissue insulin resistance in people with or at risk of type 2 diabetes. The results showed that sedentary time was positively associated with insulin resistance, while physical activity was unrelated to insulin resistance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Peripheral Vascular Disease
Norm R. C. Campbell, Paul K. Whelton, Marcelo Orias, Richard D. Wainford, Francesco P. Cappuccio, Nicole Ide, Bruce Neal, Jennifer Cohn, Laura K. Cobb, Jacqui Webster, Kathy Trieu, Feng J. He, Rachael M. McLean, Adriana Blanco-Metzler, Mark Woodward, Nadia Khan, Yoshihiro Kokubo, Leo Nederveen, JoAnne Arcand, Graham A. MacGregor, Mayowa O. Owolabi, Liu Lisheng, Gianfranco Parati, Daniel T. Lackland, Fadi J. Charchar, Bryan Williams, Maciej Tomaszewski, Cesar A. Romero, Beatriz Champagne, Mary R. L'Abbe, Michael A. Weber, Markus P. Schlaich, Agnes Fogo, Valery L. Feigin, Rufus Akinyemi, Felipe Inserra, Bindu Menon, Marcia Simas, Mario Fritsch Neves, Krassimira Hristova, Carolyn Pullen, Sanjay Pandeya, Junbo Ge, Jorge E. Jalil, Ji-Guang Wang, Jiri Wideimsky, Reinhold Kreutz, Ulrich Wenzel, Michael Stowasser, Manuel Arango, Athanasios Protogerou, Eugenia Gkaliagkousi, Flavio Danni Fuchs, Mansi Patil, Andy Wai-Kwong Chan, Janos Nemcsik, Ross T. Tsuyuki, Sanjeevi Nathamuni Narasingan, Nizal Sarrafzadegan, Maria Eugenia Ramos, Natalie Yeo, Hiromi Rakugi, Agustin J. Ramirez, Guillermo Alvarez, Adel Berbari, Cho-il Kim, Sang-Hyun Ihm, Yook-Chin Chia, Tsolmon Unurjargal, Hye Kyung Park, Kolawole Wahab, Helen McGuire, Naranjargal J. Dashdorj, Mohammed Ishaq, Deborah Ignacia D. Ona, Leilani B. Mercado-Asis, Aleksander Prejbisz, Marianne Leenaerts, Carla Simao, Fernando Pinto, Bader Ali Almustafa, Jonas Spaak, Stefan Farsky, Dragan Lovic, Xin-Hua Zhang
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Aletta E. Schutte, Tazeen H. Jafar, Neil R. Poulter, Albertino Damasceno, Nadia A. Khan, Peter M. Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J. Charchar, Myeong Chan Cho, Tomasz J. Guzik, Ghazi F. Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S. W. Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A. Romero, Markus P. Schlaich, Abdulla Shehab, Ching Siew Mooi, U. Muscha Steckelings, George Stergiou, Rhian M. Touyz, Thomas Unger, Richard D. Wainford, Ji-Guang Wang, Bryan Williams, Brandi M. Wynne, Maciej Tomaszewski
Summary: Hypertension is the leading cause of preventable death globally, but there are significant challenges in its detection, treatment, and control, particularly in low-resource settings. Disparities based on resources, sociodemographic environment, and race contribute to the disproportionate burden of hypertension-related outcomes. Immediate action is needed to address these challenges and reduce inequities in hypertension care.
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, General & Internal
Jordan H. Lai, Stella M. Gwini, Gang Chen, Katrina M. Long, Grant Russell, Markus P. Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori, Martin Wolley, Christopher M. Reid, Jun Yang
Summary: This study evaluated the willingness of the Australian general public to undergo testing for secondary causes of hypertension and identified some enablers and barriers from the patients' perspective. The results showed that the majority of patients were willing to be tested, and education about the risks and testing process may help overcome some barriers.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Krzysztof Narkiewicz, Luis Ruilope, David Hutton, Khoa Cao, Douglas A. Hettrick, Martin Fahy, Markus P. Schlaich, Michael Bohm, Jan B. Pietzsch
Summary: Renal denervation using radiofrequency has been found to lower blood pressure and reduce cardiovascular events in patients with uncontrolled hypertension. The magnitude of blood pressure reduction and associated risks of cardiovascular events vary among different high-risk subgroups. Model-based projections suggest that radiofrequency renal denervation provides significant clinical benefits for patients with uncontrolled hypertension.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Review
Peripheral Vascular Disease
Marcio Galindo Kiuchi, Revathy Carnagarin, Vance B. Matthews, Markus P. Schlaich
Summary: Cardiometabolic disorders have a significant impact on quality of life and healthcare systems globally, and the overactivation of the sympathetic nervous system is a key factor in these conditions. Although diet and exercise are traditional methods for combating metabolic disorders, they can be difficult to achieve. Current pharmaceutical approaches have variable effectiveness and may be limited by side effects and non-adherence. Complementary therapies, such as neural modulation, may be beneficial in addressing the burden of cardiometabolic disease.
HYPERTENSION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Louise M. Woodhams, Leanne Chalmers, Tin Fei Sim, Bu B. Yeap, Markus P. Schlaich, Carl Schultz, Graham S. Hillis
Summary: Recent studies have shown the need for innovative treatment options for end-stage diabetic kidney disease in many people with type 2 diabetes. In this updated systematic review and meta-analysis, the combination of SGLT2 inhibitors with ACE inhibitors and/or ARBs was found to significantly reduce albuminuria, glycated hemoglobin, and systolic blood pressure in people with type 2 diabetes compared to standard care alone.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Peripheral Vascular Disease
Thomas Beaney, Wei P. Wang, Markus E. Schlaich, Aletta S. Schutte, George Stergiou, Luis Alcocer, Jafar Alsaid, Alejandro Bimbo Diaz, Rafael Hernandez-Hernandez, Mohammad Ishaq, Jacek Jozwiak, Nadia Khan, Gaia Kiru, Harsha McCardle, Augustine Nonso Odili, Wook Bum A. Pyun, Cesar Romero, Jiguang R. Wang, Neil Poulter
Summary: The MMM 2021 assessed the global burden of hypertension during the COVID-19 pandemic and found a high proportion of untreated or inadequately treated patients, indicating the need for improved global blood pressure screening and management.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Sonali R. Gnanenthiran, Isabella Tan, Emily R. Atkins, Alberto Avolio, Belinda Bennett, Niamh Chapman, Clara K. Chow, Ruth Freed, Danijela Gnjidic, Charlotte Hespe, Baldeep Kaur, Huei Ming Liu, Anushka Patel, David Peiris, Christopher M. Reid, Markus Schlaich, James E. Sharman, George S. Stergiou, Tim Usherwood, Christopher Gianacas, Anthony Rodgers, Aletta E. Schutte
Summary: This study aims to investigate the effectiveness, safety, acceptability, and cost-effectiveness of a wearable blood pressure monitor-based care strategy in reducing clinic blood pressure. The study will enroll 600 adults with high blood pressure, comparing the intervention group using wearable-based remote care with the control group receiving usual care. The primary outcome is the difference in change in clinic systolic blood pressure between the two groups from baseline to 12 months.
AMERICAN HEART JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Omar Azzam, Sayeh Heidari Nejad, Revathy Carnagarin, Janis M. Nolde, Marcio Galindo-Kiuchi, Markus P. Schlaich
Summary: Resistant hypertension is associated with high cardiovascular risk and current guideline-recommended therapy is not sufficient. Recent landmark trials have shown promising results for novel compounds targeting unaddressed pathophysiologic pathways and catheter-based renal denervation as an effective adjunct therapeutic approach.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Janis M. Nolde, Emily Atkins, Simone Marschner, Graham S. Hillis, John Chalmers, Laurent Billot, Mark R. Nelson, Christopher M. Reid, Peter Hay, Michael Burke, Shirley Jansen, Tim Usherwood, Anthony Rodgers, Clara K. Chow, Markus P. Schlaich
Letter
Peripheral Vascular Disease
Aletta E. Schutte, Isabella Tan, Sonali R. Gnanenthiran, Justine Chan, Konstantinos G. Kyriakoulis, Markus P. Schlaich, Anthony Rodgers, George S. Stergiou
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Lakshini Yasaswi Herat, Jennifer Rose Matthews, Moira Hibbs, Elizabeth Piroska Rakoczy, Markus Peter Schlaich, Vance Bruce Matthews
Summary: SGLTs are transport proteins that can be inhibited to improve glycemic control and provide cardiorenal benefits. Dual SGLT1/2 inhibitors, such as sotagliflozin, target both SGLT1 and 2 proteins.
Review
Endocrinology & Metabolism
Saeede Saadati, Kaveh Naseri, Omid Asbaghi, Mohsen Yousefi, Elnaz Golalipour, Barbora de Courten
Summary: Studies have shown that probiotics and synbiotics have beneficial effects on body weight and composition in adults, making them useful as add-ons to weight loss products and medications.
Review
Biochemistry & Molecular Biology
Jennifer Matthews, Lakshini Herat, Markus P. Schlaich, Vance Matthews
Summary: Chronic Kidney Disease (CKD) and Cardiovascular Disease (CVD) can occur together as cardiorenal disease. Sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors show promise in treating cardiorenal disease by improving various indicators through multiple mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
