M2 macrophages and their role in rheumatic diseases

CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease

(2018) Pedro Salvador et al.   Journal of Crohns & Colitis

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus

(2018) Nehal Narayan et al.   JOURNAL OF NUCLEAR MEDICINE

Inverse correlation between the number of CXCR3+ macrophages and the severity of inflammatory lesions in Sjögren's syndrome salivary glands: A pilot study

(2018) Keiko Aota et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats

(2018) W. W. Tong et al.   Scientific Reports

M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

(2018) Shoichi Fukui et al.   Frontiers in Immunology

Macrophage-specific nanotechnology-driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions

(2017) Perla Abigail Alvarado-Vazquez et al.   IMMUNOBIOLOGY

Is macrophage polarization important in rheumatoid arthritis?

(2017) Yang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis

(2017) Wen Sun et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A Novel Subset of Anti-Inflammatory CD138+Macrophages Is Deficient in Mice with Experimental Lupus

(2017) Shuhong Han et al.   JOURNAL OF IMMUNOLOGY

Significance of M2 macrophages in glomerulonephritis with crescents

(2017) Jun Li et al.   PATHOLOGY RESEARCH AND PRACTICE

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

(2017) Allah Nawaz et al.   Nature Communications

CD14+ Cells with the Phenotype of Infiltrated Monocytes Consist of Distinct Populations Characterized by Anti-inflammatory as well as Pro-inflammatory Activity in Gouty Arthritis

(2017) Ji Hye Jeong et al.   Frontiers in Immunology

SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis

(2017) So Youn Park et al.   Frontiers in Immunology

Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway

(2017) Ruiling Liu et al.   PLoS One

Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease

(2017) Sachiko Furukawa et al.   Scientific Reports

Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease

(2017) Dong Hyuk Seo et al.   Scientific Reports

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Differential Macrophage Polarization from Pneumocystis in Immunocompetent and Immunosuppressed Hosts: Potential Adjunctive Therapy during Pneumonia

(2016) Vijayalakshmi Nandakumar et al.   INFECTION AND IMMUNITY

IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis

(2016) Junfeng Zhang et al.   JOURNAL OF IMMUNOLOGY

Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis

(2016) Nobuhide Endo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro , but not inhibited directly by anti-inflammatory (M2) macrophages

(2016) L. Utomo et al.   OSTEOARTHRITIS AND CARTILAGE

Monogenic polyarteritis: the lesson of ADA2 deficiency

(2016) Roberta Caorsi et al.   Pediatric Rheumatology

Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis

(2016) Tae-Hoon Shin et al.   Cell Death & Disease

Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis

(2015) Shardool Jain et al.   BIOMATERIALS

Macrophage Polarization Modulates Development of Systemic Lupus Erythematosus

(2015) Feng Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease

(2015) Sachiko Furukawa et al.   CLINICAL IMMUNOLOGY

Anti-Citrullinated Protein Antibodies Induce Macrophage Subset Disequilibrium in RA Patients

(2015) Wei Zhu et al.   INFLAMMATION

The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

(2015) Judit Svensson-Arvelund et al.   JOURNAL OF IMMUNOLOGY

Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13

(2015) Shanshan Gao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo

(2015) Michiel Siebelt et al.   ARTHRITIS RESEARCH & THERAPY

Expression of dectin-1 and enhanced activation of NALP3 inflammasome are associated with resistance to paracoccidioidomycosis

(2015) Claudia Feriotti et al.   Frontiers in Microbiology

Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis

(2015) Hikmat N. Daghestani et al.   Arthritis & Rheumatology

MGL Receptor and Immunity: When the Ligand Can Make the Difference

(2015) Ilaria Grazia Zizzari et al.   Journal of Immunology Research

Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation

(2015) Chitra Dhanasekar et al.   PLoS One

M2 Macrophage Infiltrates in the Early Stages of ANCA-Associated Pauci-Immune Necrotizing GN

(2014) L. Zhao et al.   Clinical Journal of the American Society of Nephrology

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Disequilibrium of M1 and M2 Macrophages Correlates with the Development of Experimental Inflammatory Bowel Diseases

(2014) Wei Zhu et al.   IMMUNOLOGICAL INVESTIGATIONS

Soluble CD25 in serum: a potential marker for subclinical macrophage activation syndrome in patients with active systemic onset juvenile idiopathic arthritis

(2014) Vishnu V. Reddy et al.   International Journal of Rheumatic Diseases

Dectin-1 Induces M1 Macrophages and Prominent Expansion of CD8+IL-17+ Cells in Pulmonary Paracoccidioidomycosis

(2014) Flávio V. Loures et al.   JOURNAL OF INFECTIOUS DISEASES

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

(2014) Charles D. Mills et al.   Journal of Innate Immunity

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

(2014) Qing Zhou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

(2014) N. Fahy et al.   OSTEOARTHRITIS AND CARTILAGE

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

(2014) Lisa T. C. Vogelpoel et al.   Nature Communications

Inhibition of Fucosylation Reshapes Inflammatory Macrophages and Suppresses Type II Collagen-Induced Arthritis

(2014) Jun Li et al.   Arthritis & Rheumatology

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

(2014) Zhihong Yang et al.   Frontiers in Immunology

Increased release of soluble CD163 by the peripheral blood mononuclear cells is associated with worse prognosis in patients with systemic sclerosis

(2013) M Bielecki et al.   Advances in Medical Sciences

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages

(2013) K. Furuhashi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mannose-Binding Lectin Blunts Macrophage Polarization and Ameliorates Lupus Nephritis

(2013) Yanxing Cai et al.   PLoS One

Macrophage phenotype in the subclinical gut inflammation of patients with ankylosing spondylitis

(2013) F. Ciccia et al.   RHEUMATOLOGY

Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

(2013) Gaetano Zizzo et al.   ARTHRITIS RESEARCH & THERAPY

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis

(2012) Carmen A Ambarus et al.   ARTHRITIS RESEARCH & THERAPY

Familial and Acquired Hemophagocytic Lymphohistiocytosis

(2011) G.E. Janka   Annual Review of Medicine

Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension

(2011) Romy B. Christmann et al.   ARTHRITIS AND RHEUMATISM

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

A Phosphorus-Based Dendrimer Targets Inflammation and Osteoclastogenesis in Experimental Arthritis

(2011) M. Hayder et al.   Science Translational Medicine

A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis

(2010) Judilyn Fuentes-Duculan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype

(2010) Susan K Mathai et al.   LABORATORY INVESTIGATION

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

(2010) Nobuyo Higashi-Kuwata et al.   ARTHRITIS RESEARCH & THERAPY

PPARγ Controls Dectin-1 Expression Required for Host Antifungal Defense against Candida albicans

(2010) Amandine Galès et al.   PLoS Pathogens

Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis

(2009) Bernard Vandooren et al.   ARTHRITIS AND RHEUMATISM

Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout

(2009) William John Martin et al.   ARTHRITIS AND RHEUMATISM

The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria

(2008) B. O. Fabriek et al.   BLOOD

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY