Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

Duodenal Cytochrome B Expression Stimulates Iron Uptake by Human Intestinal Epithelial Cells

(2018) Gladys O. Latunde-Dada et al.   JOURNAL OF NUTRITION

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanistic and regulatory aspects of intestinal iron absorption

(2014) Sukru Gulec et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

How Are Cytochrome b561 Electron Currents Controlled by Membrane Voltage and Substrate Availability?

(2014) Cristiana Picco et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular liaisons between erythropoiesis and iron metabolism

(2014) L. Kautz et al.   BLOOD

Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase

(2014) Peilong Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Transport through Ferroportin Is Induced by Intracellular Ascorbate and Involves IRP2 and HIF2α

(2014) Nathalie Scheers et al.   Nutrients

The physiological functions of iron regulatory proteins in iron homeostasis - an update

(2014) De-Liang Zhang et al.   Frontiers in Pharmacology

The IRP/IRE system in vivo: insights from mouse models

(2014) Nicole Wilkinson et al.   Frontiers in Pharmacology

Special delivery: distributing iron in the cytosol of mammalian cells

(2014) Caroline C. Philpott et al.   Frontiers in Pharmacology

Electron Transfer Reactions of Candidate Tumor Suppressor 101F6 Protein, a Cytochrome b561 Homologue, with Ascorbate and Monodehydroascorbate Radical

(2013) Mariam C. Recuenco et al.   BIOCHEMISTRY

Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism

(2013) Darius J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells

(2013) Miguel Arredondo et al.   BIOMETALS

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

(2013) M. Mastrogiannaki et al.   BLOOD

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

(2013) N. Wilkinson et al.   BLOOD

Regulation of erythropoiesis by hypoxia-inducible factors

(2013) Volker H. Haase   BLOOD REVIEWS

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins

(2013) Oliver Stehling et al.   Cell Metabolism

Intestinal Iron Absorption: Regulation by Dietary & Systemic Factors

(2013) Paul A. Sharp   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Transcription Factors Sp1 and Hif2α Mediate Induction of the Copper-transporting ATPase ( Atp7a ) Gene in Intestinal Epithelial Cells during Hypoxia

(2013) Liwei Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels

(2013) Michael Li-Hsuan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divalent metal transporter 1 (Dmt1) Mediates Copper Transport in the Duodenum of Iron-Deficient Rats and When Overexpressed in Iron-Deprived HEK-293 Cells

(2013) Lingli Jiang et al.   JOURNAL OF NUTRITION

Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2α and Altered Expression of Iron Absorption Genes in Mice

(2013) Pavle Matak et al.   PLoS One

Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders

(2013) Andrea Steinbicker et al.   Nutrients

Cytochromes b561: Ascorbate-Mediated Trans-Membrane Electron Transport

(2012) Han Asard et al.   ANTIOXIDANTS & REDOX SIGNALING

Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action

(2012) Alfons Lawen et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroportin-mediated iron transport: Expression and regulation

(2012) Diane M. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian iron metabolism and its control by iron regulatory proteins

(2012) Cole P. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

Dihydrolipoic acid reduces cytochrome b561 proteins

(2012) Alajos Bérczi et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions

(2012) Jeehyea Choi et al.   JOURNAL OF NUTRITION

Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2α) in intestinal epithelial cells

(2011) Liwei Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Duodenal cytochrome b (Cybrd 1) and HIF-2α expression during acute hypoxic exposure in mice

(2011) Gladys O. Latunde-Dada et al.   EUROPEAN JOURNAL OF NUTRITION

Quercetin–iron chelates are transported via glucose transporters

(2011) Evangelia Vlachodimitropoulou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

A role for Na+/H+exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane

(2010) Darius J.R. Lane et al.   BIOCHEMICAL JOURNAL

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

(2010) Darius J.R. Lane et al.   BIOCHEMICAL JOURNAL

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function

(2010) Bruno Galy et al.   Cell Metabolism

Quercetin is a substrate for the transmembrane oxidoreductase Dcytb

(2010) Evangelia Vlachodimitropoulou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cellsin VivoThat Is Controlled at the Level of Protein Stability

(2010) Yasuhiro Nose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-mediated biological control

(2010) Jessica Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Hepcidin, the hormone of iron metabolism, is bound specifically to  -2-macroglobulin in blood

(2009) G. Peslova et al.   BLOOD

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

(2009) G. L. Semenza   BLOOD

A novel association between a SNP inCYBRD1and serum ferritin levels in a cohort study ofHFEhereditary haemochromatosis

(2009) Clare C. Constantine et al.   BRITISH JOURNAL OF HAEMATOLOGY

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Regulation of Intestinal Iron Absorption: The Mucosa Takes Control?

(2009) Robert J. Simpson et al.   Cell Metabolism

Ascorbate and plasma membrane electron transport—Enzymes vs efflux

(2009) Darius J.R. Lane et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

(2009) A. A. Salahudeen et al.   SCIENCE

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

(2009) A. A. Vashisht et al.   SCIENCE

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

The role of Dcytb in iron metabolism: an update

(2008) Andrew T. McKie   BIOCHEMICAL SOCIETY TRANSACTIONS

Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum

(2008) Bruno Galy et al.   Cell Metabolism

Dcytb (Cybrd1) functions as both a ferric and a cupric reductase in vitro

(2008) Steven Wyman et al.   FEBS LETTERS

Non-transferrin Iron Reduction and Uptake Are Regulated by Transmembrane Ascorbate Cycling in K562 Cells

(2008) Darius J. R. Lane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess

(2008) Kamila Balusikova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL

Recombinant Expression and Initial Characterization of the Putative Human Enteric Ferric Reductase Dcytb†

(2007) Susanne Ludwiczek et al.   BIOCHEMISTRY

Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism

(2007) Jonathan S. Oakhill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS