The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Intestinal Iron Absorption: Regulation by Dietary & Systemic Factors

(2013) Paul A. Sharp   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2α and Altered Expression of Iron Absorption Genes in Mice

(2013) Pavle Matak et al.   PLoS One

Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption

(2013) Bruno Galy et al.   Cell Reports

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian iron metabolism and its control by iron regulatory proteins

(2012) Cole P. Anderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase

(2012) William A. Denny   JOURNAL OF MEDICINAL CHEMISTRY

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

(2012) Petr Vachal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions

(2012) Jeehyea Choi et al.   JOURNAL OF NUTRITION

 -thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

(2011) Y. Ginzburg et al.   BLOOD

Regulation of hepcidin expression at high altitude

(2011) N. P. Talbot et al.   BLOOD

Deletion of HIF-2  in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

(2011) M. Mastrogiannaki et al.   BLOOD

Lack of iron-related phenotype in Sp6 intestinal knockout mice

(2011) Pavle Matak et al.   BLOOD CELLS MOLECULES AND DISEASES

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation

(2011) Carole Brasse–Lagnel et al.   GASTROENTEROLOGY

Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved

(2011) Qian-Qian Luo et al.   IUBMB LIFE

Intestinal Hypoxia-inducible Factor-2α (HIF-2α) Is Critical for Efficient Erythropoiesis

(2011) Erik R. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Regulatory Protein 1 Outcompetes Iron Regulatory Protein 2 in Regulating Cellular Iron Homeostasis in Response to Nitric Oxide

(2011) Agnieszka Styś et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Inducible Factor-2α Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats

(2011) McKale R. Davis et al.   JOURNAL OF NUTRITION

The Molecular Pathogenesis of Hereditary Hemochromatosis

(2011) Jodie Babitt et al.   SEMINARS IN LIVER DISEASE

Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project

(2010) A. Piperno et al.   BLOOD

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Heme and non-heme iron transporters in non-polarized and polarized cells

(2010) Izumi Yanatori et al.   BMC CELL BIOLOGY

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

(2010) Liviu Vanoaica et al.   Cell Metabolism

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure

(2010) Surjit K. Srai et al.   KIDNEY INTERNATIONAL

Natural selection on EPAS1 (HIF2 ) associated with low hemoglobin concentration in Tibetan highlanders

(2010) C. M. Beall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Not all DMT1 mutations lead to iron overload

(2009) Esther Blanco et al.   BLOOD CELLS MOLECULES AND DISEASES

A novel association between a SNP inCYBRD1and serum ferritin levels in a cohort study ofHFEhereditary haemochromatosis

(2009) Clare C. Constantine et al.   BRITISH JOURNAL OF HAEMATOLOGY

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression

(2009) De-Liang Zhang et al.   Cell Metabolism

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

(2009) A. A. Vashisht et al.   SCIENCE

Animal Models of Anemia of Inflammation

(2009) Seth Rivera et al.   SEMINARS IN HEMATOLOGY

Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium

(2008) Kwo-yih Yeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Iron metabolism in the anemia of chronic disease

(2008) Günter Weiss   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism

(2008) D. Ferring-Appel et al.   BLOOD

Forging a field: the golden age of iron biology

(2008) N. C. Andrews   BLOOD

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

(2008) N. J. Foot et al.   BLOOD

Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum

(2008) Bruno Galy et al.   Cell Metabolism

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Hepcidin inhibits apical iron uptake in intestinal cells

(2007) Natalia P. Mena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells

(2007) T Chaston et al.   GUT