Cardiac RNA Induces Inflammatory Responses in Cardiomyocytes and Immune CellsviaToll-like Receptor 7 Signaling

A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer

(2014) C Zhu et al.   BRITISH JOURNAL OF CANCER

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

(2014) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

Role of Extracellular RNA and TLR3‐Trif Signaling in Myocardial Ischemia–Reperfusion Injury

(2014) Chan Chen et al.   Journal of the American Heart Association

Investigation of cell free BIRC5 mRNA as a serum diagnostic and prognostic biomarker for colorectal cancer

(2013) Haiyan Wang et al.   JOURNAL OF SURGICAL ONCOLOGY

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

(2013) Eva Brencicova et al.   Frontiers in Cellular and Infection Microbiology

Circulating MicroRNAs

(2012) Esther E. Creemers et al.   CIRCULATION RESEARCH

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells

(2011) Diana M. Lim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

MyD88 and Trif Signaling Play Distinct Roles in Cardiac Dysfunction and Mortality during Endotoxin Shock and Polymicrobial Sepsis

(2011) Yan Feng et al.   ANESTHESIOLOGY

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

RNA released from necrotic keratinocytes upregulates intercellular adhesion molecule-1 expression in melanocytes

(2011) Shujie Zhang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Circulating MicroRNAs

(2011) Stephan Fichtlscherer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myocardial Ischemia Activates an Injurious Innate Immune Signaling via Cardiac Heat Shock Protein 60 and Toll-like Receptor 4

(2011) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiviral responses induced by the TLR3 pathway

(2011) Misako Matsumoto et al.   REVIEWS IN MEDICAL VIROLOGY

Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury

(2010) Yan Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis*

(2010) Lin Zou et al.   CRITICAL CARE MEDICINE

Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells

(2010) M. Baiersdörfer et al.   EXPERIMENTAL CELL RESEARCH

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice

(2008) Yan Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNAs as extracellular signaling molecules

(2008) Marcel E Dinger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY