Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

HIT-antibodies promote their own antigen

(2012) A. Greinacher et al.   BLOOD

Dynamic antibody-binding properties in the pathogenesis of HIT

(2012) B. S. Sachais et al.   BLOOD

Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes

(2012) K. Krauel et al.   BLOOD

Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration

(2012) Ciro Costagliola et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Nucleic acids in circulation: Are they harmful to the host?

(2012) Indraneel Mittra et al.   JOURNAL OF BIOSCIENCES

Binding of heparin-dependent antibodies to PF4 modified by enoxaparin oligosaccharides: evaluation by surface plasmon resonance and serotonin release assay

(2012) D. LEROUX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural Requirements for the Procoagulant Activity of Nucleic Acids

(2012) Julia Gansler et al.   PLoS One

Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons

(2011) X. Ni et al.   CURRENT MEDICINAL CHEMISTRY

Fatal Outcome in Bacteremia is Characterized by High Plasma Cell Free DNA Concentration and Apoptotic DNA Fragmentation: A Prospective Cohort Study

(2011) Reetta Huttunen et al.   PLoS One

The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia

(2009) N. Lubenow et al.   BLOOD

An Exosite-Specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and Enhances Inhibition by Protein C Inhibitor

(2009) Jens Müller et al.   CHEMISTRY & BIOLOGY

Optimization of a murine immunization model for study of PF4/heparin antibodies

(2009) S. SUVARNA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heparin–platelet factor 4 antibodies in intensive care patients: an observational seroprevalence study

(2009) Robert L. Levine et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

A Spontaneous Prothrombotic Disorder Resembling Heparin-induced Thrombocytopenia

(2008) Theodore E. Warkentin et al.   AMERICAN JOURNAL OF MEDICINE

Fatal heparin-induced thrombocytopenia (HIT) during warfarin thromboprophylaxis following orthopedic surgery: another example of ‘spontaneous’ HIT?

(2008) R. M. JAY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heparin-induced thrombocytopenia - therapeutic concentrations of danaparoid, unlike fondaparinux and direct thrombin inhibitors, inhibit formation of platelet factor 4-heparin complexes

(2008) K. KRAUEL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heparin-induced thrombocytopenia (HIT) during postoperative warfarin thromboprophylaxis: a second example of postorthopedic surgery ‘spontaneous’ HIT

(2008) R. K. PRUTHI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS