Metal complexes as potential modulators of inflammatory and autoimmune responses

Organoiridium Complexes: Anticancer Agents and Catalysts

(2014) Zhe Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antagonizing STAT3 Dimerization with a Rhodium(III) Complex

(2014) Dik-Lung Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal complexes as structural templates for targeting proteins

(2014) Markus Dörr et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The expanding role of IL-7 and thymic stromal lymphopoietin as therapeutic target for rheumatoid arthritis

(2014) Kamla Pathak   EXPERT OPINION ON THERAPEUTIC TARGETS

Manganese(II) Complexes with the Non-steroidal Anti-Inflammatory Drug Tolfenamic Acid: Structure and Biological Perspectives

(2014) Marianthi Zampakou et al.   INORGANIC CHEMISTRY

A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo

(2014) Li-Juan Liu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor

(2014) Michael Kaplanis et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

(2014) Catherine M. Clavel et al.   Chemical Science

Antagonism of mTOR Activity by a Kinetically Inert Rhodium(III) Complex

(2014) Hai-Jing Zhong et al.   ChemPlusChem

The path for metal complexes to a DNA target

(2013) Alexis C. Komor et al.   CHEMICAL COMMUNICATIONS

Self-activating nuclease and anticancer activities of copper(ii) complexes with aryl-modified 2,6-di(thiazol-2-yl)pyridine

(2013) Lüying Li et al.   DALTON TRANSACTIONS

Method for the Preparation of Nonracemic Bis-Cyclometalated Iridium(III) Complexes

(2013) Melanie Helms et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Synthesis, characterization, and anticancer activity of ruthenium(II)-β-carboline complex

(2013) Yu Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Uses for Old Drugs: Attempts to Convert Quinolone Antibacterials into Potential Anticancer Agents Containing Ruthenium

(2013) Jakob Kljun et al.   INORGANIC CHEMISTRY

Copper(II) interacting with the non-steroidal antiinflammatory drug flufenamic acid: Structure, antioxidant activity and binding to DNA and albumins

(2013) Charikleia Tolia et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Transition metal complexes of s-triazine derivative: new class of anticonvulsant, anti-inflammatory, and neuroprotective agents

(2013) R. Shanmugakala et al.   MEDICINAL CHEMISTRY RESEARCH

Effect of 2-Chloro-Substitution of Adenine Moiety in Mixed-Ligand Gold(I) Triphenylphosphine Complexes on Anti-Inflammatory Activity: The Discrepancy between the In Vivo and In Vitro Models

(2013) Jan Hošek et al.   PLoS One

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

(2013) Yihui Fan et al.   Protein & Cell

Anticancer metallodrug research analytically painting the “omics” picture—current developments and future trends

(2012) Michael Groessl et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Metal-Based Inhibitor of Tumor Necrosis Factor-α

(2012) Chung-Hang Leung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developing ROS Scavenging Agents for Pharmacological Purposes: Recent Advances in Design of Manganese-Based Complexes with Anti-Inflammatory and Anti- Nociceptive Activity

(2012) D. Bani et al.   CURRENT MEDICINAL CHEMISTRY

The potential of organometallic complexes in medicinal chemistry

(2012) Gilles Gasser et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rhodium(III) and iridium(III) complexes as anticancer agents

(2012) Yvonne Geldmacher et al.   INORGANICA CHIMICA ACTA

Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives

(2012) Zdeněk Trávníček et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory and selective COX-2 inhibitory activities of metal complexes of Schiff bases derived from aldoses

(2012) Mohammad S. Iqbal et al.   MEDICINAL CHEMISTRY RESEARCH

Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics

(2012) Bogumiła Kupcewicz et al.   MEDICINAL CHEMISTRY RESEARCH

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

(2012) Chung-Hang Leung et al.   MedChemComm

Therapeutic applications of gold complexes: lipophilic gold(iii) cations and gold(i) complexes for anti-cancer treatment

(2011) Chi-Ming Che et al.   CHEMICAL COMMUNICATIONS

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(iii) N-methoxyalkylpyridylporphyrins

(2011) Artak G. Tovmasyan et al.   DALTON TRANSACTIONS

Metal-based antitumour drugs in the post-genomic era: what comes next?

(2011) Gianni Sava et al.   DALTON TRANSACTIONS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Non-steroidal antiinflammatory drug–copper(ii) complexes: Structure and biological perspectives

(2011) Filitsa Dimiza et al.   DALTON TRANSACTIONS

Sensing disease and danger: A survey of vertebrate PRRs and their origins

(2011) John D. Hansen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cobalt(II) complexes with non-steroidal anti-inflammatory drug tolfenamic acid: Structure and biological evaluation

(2011) Sofia Tsiliou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

(2011) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-steroidal anti-inflammatory drug diflunisal interacting with Cu(II). Structure and biological features

(2011) Stella Fountoulaki et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Biological evaluation of cobalt(II) complexes with non-steroidal anti-inflammatory drug naproxen

(2011) Filitsa Dimiza et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation

(2011) Jordan S. Fridman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Retooling Manganese(III) Porphyrin-Based Peroxynitrite Decomposition Catalysts for Selectivity and Oral Activity: A Potential New Strategy for Treating Chronic Pain

(2011) Smita Rausaria et al.   JOURNAL OF MEDICINAL CHEMISTRY

Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers

(2011) Smita Rausaria et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes

(2011) Walfrido Bispo Júnior et al.   MOLECULES

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

(2010) Ines Batinic-Haberle et al.   AMINO ACIDS

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-inflammatory AreneChromium Complexes Acting as Specific Inhibitors of NOD2 Signalling

(2010) Harald Bielig et al.   ChemMedChem

Biological evaluation of non-steroidal anti-inflammatory drugs-cobalt(ii) complexes

(2010) Filitsa Dimiza et al.   DALTON TRANSACTIONS

Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents

(2010) Rekha S. Hoonur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells

(2010) Xuesen Yang et al.   Journal of Neuroinflammation

Auranofin, a Gold(I)-Containing Antirheumatic Compound, Activates Keap1/Nrf2 Signaling via Rac1/iNOS Signal and Mitogen-Activated Protein Kinase Activation

(2010) Nam-Hoon Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

(2010) H.-W. Lo et al.   MOLECULAR CANCER RESEARCH

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

(2009) M. D. Säemann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase

(2009) Valentina Gandin et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes

(2009) Saeed Arayne et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein–protein interactions

(2009) Joel A. Drewry et al.   CHEMICAL COMMUNICATIONS

Regulation of nitric oxide production in health and disease

(2009) Yvette C Luiking et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lipophilicity of potent porphyrin-based antioxidants: Comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins

(2009) Ivan Kos et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Novel Manganese Complex Effective as Superoxide Anion Scavenger and Therapeutic Agent against Cell and Tissue Oxidative Injury

(2009) Paola Failli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in ruthenium anticancer drugs

(2009) Aviva Levina et al.   Metallomics

Effect of the oligo(ethylene glycol) group on the antioxidant activity of manganese salen complexes

(2008) Wonchoul Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Current Status and Future Prospects for Satraplatin, an Oral Platinum Analogue

(2008) H. Choy et al.   CLINICAL CANCER RESEARCH

Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: The effect of charge distribution

(2008) Júlio S. Rebouças et al.   DALTON TRANSACTIONS

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Medical Treatment of Advanced Testicular Cancer

(2008) Darren R. Feldman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection

(2007) Benjamin Gauter-Fleckenstein et al.   FREE RADICAL BIOLOGY AND MEDICINE