Anticancer metallodrug research analytically painting the “omics” picture—current developments and future trends

Accumulation, Fractionation, and Analysis of Platinum in Toxicologically Affected Tissues after Cisplatin, Oxaliplatin, and Carboplatin Administration

(2013) D. Esteban-Fernandez et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Redox activation of metal-based prodrugs as a strategy for drug delivery

(2012) Nora Graf et al.   ADVANCED DRUG DELIVERY REVIEWS

The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes

(2012) Sebastian Blanck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Targeted therapy vs. DNA-adduct formation-guided design: thoughts about the future of metal-based anticancer drugs

(2012) Gianni Sava et al.   DALTON TRANSACTIONS

Capillary electrophoretic methods in the development of metal-based therapeutics and diagnostics: New methodology and applications

(2012) Anna K. Bytzek et al.   ELECTROPHORESIS

Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

(2012) Alexey A. Nazarov et al.   INORGANIC CHEMISTRY

Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compounds

(2012) Francesca Guidi et al.   Metallomics

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

(2011) Samuel M. Meier et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Use of Top-Down and Bottom-Up Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Mapping Calmodulin Sites Modified by Platinum Anticancer Drugs

(2011) Huilin Li et al.   ANALYTICAL CHEMISTRY

Elemental Bioimaging in Kidney by LA–ICP–MS As a Tool to Study Nephrotoxicity and Renal Protective Strategies in Cisplatin Therapies

(2011) Estefanía Moreno-Gordaliza et al.   ANALYTICAL CHEMISTRY

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine

(2011) M. Joerger et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

(2011) Bin Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

(2011) Lorien J. Parker et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal-based antitumour drugs in the post-genomic era: what comes next?

(2011) Gianni Sava et al.   DALTON TRANSACTIONS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Mass-spectrometric characterization of cisplatin binding sites on native and denatured ubiquitin

(2011) Ting Zhao et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metal-Based Inhibition of Poly(ADP-ribose) Polymerase − The Guardian Angel of DNA

(2011) Filipa Mendes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

LC– and CZE–ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(iii)] (KP1339) in mouse plasma

(2011) Anna K. Bytzek et al.   Metallomics

Visualising gold inside tumour cells following treatment with an antitumour gold(i) complex

(2011) Louise E. Wedlock et al.   Metallomics

Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin

(2011) Michael Groessl et al.   Metallomics

Mapping intact protein isoforms in discovery mode using top-down proteomics

(2011) John C. Tran et al.   NATURE

Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

(2011) Bin Wu et al.   NUCLEIC ACIDS RESEARCH

A Gene Expression Signature of Acquired Chemoresistance to Cisplatin and Fluorouracil Combination Chemotherapy in Gastric Cancer Patients

(2011) Hark Kyun Kim et al.   PLoS One

Cell response of Escherichia coli to cisplatin-induced stress

(2011) Maria Stefanopoulou et al.   PROTEOMICS

Waiting for the Revolution

(2011) E. Marshall   SCIENCE

Novel insights into the bottom-up mass spectrometry proteomics approach for the characterization of Pt-binding proteins: The insulin-cisplatin case study

(2010) Estefanía Moreno-Gordaliza et al.   ANALYST

Selective Aggregation of a Platinum-Gadolinium Complex Within a Tumor-Cell Nucleus

(2010) Ellen L. Crossley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Determination of Cisplatin 1,2-Intrastrand Guanine−Guanine DNA Adducts in Human Leukocytes by High-Performance Liquid Chromatography Coupled to Inductively Coupled Plasma Mass Spectrometry

(2010) Chris F. Harrington et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

(2010) Leticia Cubo et al.   ChemMedChem

The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

(2010) Anna K. Bytzek et al.   ELECTROPHORESIS

Determination of Pt–DNA adducts and the sub-cellular distribution of Pt in human cancer cell lines and the leukocytes of cancer patients, following mono- or combination treatments, by inductively-coupled plasma mass spectrometry

(2010) Aref Zayed et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS

(2010) Michael Groessl et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3β

(2010) G. Ekin Atilla-Gokcumen et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry

(2010) Michael Groessl et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stability, accumulation and cytotoxicity of an albumin-cisplatin adduct

(2010) Charlotte Møller et al.   Metallomics

Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs

(2010) S. B. Howell et al.   MOLECULAR PHARMACOLOGY

Has the revolution arrived?

(2010) Francis Collins   NATURE

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Quantitative methods for studying DNA interactions with chemotherapeutic cisplatin

(2010) Daniel García Sar et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Quantitative Profiling of in Vivo Generated Cisplatin−DNA Adducts Using Different Isotope Dilution Strategies

(2009) D. García Sar et al.   ANALYTICAL CHEMISTRY

Top-Down Mass Spectrometric Approach for the Full Characterization of Insulin−Cisplatin Adducts

(2009) Estefanía Moreno-Gordaliza et al.   ANALYTICAL CHEMISTRY

Proteomics by Mass Spectrometry: Approaches, Advances, and Applications

(2009) John R. Yates et al.   Annual Review of Biomedical Engineering

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study

(2009) Frederike Lentz et al.   ANTI-CANCER DRUGS

The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase

(2009) Peng Xie et al.   BIOCHEMISTRY

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Platinum Drug Distribution in Cancer Cells and Tumors

(2009) Alice V. Klein et al.   CHEMICAL REVIEWS

Metallomics: the concept and methodology

(2009) Sandra Mounicou et al.   CHEMICAL SOCIETY REVIEWS

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

(2009) Alberto Bindoli et al.   COORDINATION CHEMISTRY REVIEWS

The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques

(2009) Michael Groessl et al.   ELECTROPHORESIS

Comparison of two CE-ICP-MS interfaces and quantitative measurements of carboplatin in plasma samples using an internal standard

(2009) Charlotte Møller et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Quantification of cisplatin, carboplatin and oxaliplatin in spiked human plasma samples by ICP-SFMS and hydrophilic interaction liquid chromatography (HILIC) combined with ICP-MS detection

(2009) Thomas Falta et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Serum-protein interactions with anticancer Ru(III) complexes KP1019 and KP418 characterized by EPR

(2009) Naniye Cetinbas et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A mass spectrometric comparison of the interactions of cisplatin and transplatin with myoglobin

(2009) Ting Zhao et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell Extracts

(2009) Yonit Kasherman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray microspectroscopy

(2009) R. Ortega et al.   Journal of the Royal Society Interface

Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action

(2009) Angela Casini et al.   Metallomics

Recent developments in ruthenium anticancer drugs

(2009) Aviva Levina et al.   Metallomics

Analytical methodologies for metallomics studies of antitumor Pt-containing drugs

(2009) Diego Esteban-Fernández et al.   Metallomics

Applying mass spectrometry-based proteomics to genetics, genomics and network biology

(2009) Matthias Gstaiger et al.   NATURE REVIEWS GENETICS

Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients

(2009) A V Khrunin et al.   PHARMACOGENOMICS JOURNAL

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

(2009) Alex N. Bullock et al.   PLoS One

Translating genomics into clinical practice: Applications in lung cancer

(2009) Aubrey Jolly Graham et al.   Current Oncology Reports

Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity

(2008) Peng Xie et al.   ACS Chemical Biology

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin

(2008) E. E. M. Brouwers et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metallomics and metalloproteomics

(2008) W. Shi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

(2008) G. Ekin Atilla-Gokcumen et al.   CHEMBIOCHEM

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry. Short Communication

(2008) Michael Groessl et al.   CHEMISTRY & BIODIVERSITY

Platinum Drug Adduct Formation in the Nucleosome Core Alters Nucleosome Mobility but Not Positioning

(2008) Bin Wu et al.   CHEMISTRY & BIOLOGY

Characterisation of Cisplatin Binding Sites in Human Serum Proteins Using Hyphenated Multidimensional Liquid Chromatography and ESI Tandem Mass Spectrometry

(2008) Joanna Will et al.   ChemMedChem

Proteomics-driven cancer biomarker discovery: looking to the future

(2008) Richard J Simpson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

(2008) Michael Groessl et al.   ELECTROPHORESIS

High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides

(2008) Alexander E. Egger et al.   INORGANIC CHEMISTRY

Mammalian cells loaded with platinum-containing molecules are sensitized to fast atomic ions

(2008) N. Usami et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

(2008) Alexander E. Egger et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

CZE–ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP

(2008) Michael Groessl et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Stability of an organometallic ruthenium–ubiquitin adduct in the presence of glutathione: Relevance to antitumour activity

(2008) Christian G. Hartinger et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Analytical methodologies for the determination of cisplatin

(2008) M. Espinosa Bosch et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

(2008) Jasna Maksimoska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

(2008) Elke E.M. Brouwers et al.   MASS SPECTROMETRY REVIEWS

A genomic approach to identify molecular pathways associated with chemotherapy resistance

(2008) Richard F. Riedel et al.   MOLECULAR CANCER THERAPEUTICS

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE

Synthetic fluorescent sensors for studying the cell biology of metals

(2008) Dylan W Domaille et al.   Nature Chemical Biology

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

(2007) Christian G. Hartinger et al.   INORGANIC CHEMISTRY