From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data

The dawning of a new age of toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Food for thought … on the evolution of toxicology and the phasing out of animal testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

(2015) Anna Bal-Price et al.   ARCHIVES OF TOXICOLOGY

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

(2014) Nina V. Balmer et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomics directory of chemically exposed human hepatocytes

(2014) Marianna Grinberg et al.   ARCHIVES OF TOXICOLOGY

Epigenetics and Transcriptomics to Detect Adverse Drug Effects in Model Systems of Human Development

(2014) Nina V. Balmer et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells

(2014) Jérémy Hamon et al.   BMC Systems Biology

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

(2014) Tanja Waldmann et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

(2014) Lisa Fredriksson et al.   TOXICOLOGICAL SCIENCES

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+

(2014) A K Krug et al.   Cell Death & Disease

Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

(2014) Bas Blaauboer   ALTEX-Alternatives to Animal Experimentation

Metabolomics in toxicology and preclinical research

(2014) Tzutzuy Ramirez   ALTEX-Alternatives to Animal Experimentation

Consensus report on the future of animal-free systemic toxicity testing

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Current approaches and future role of high content imaging in safety sciences and drug discovery

(2014) Erwin van Vliet   ALTEX-Alternatives to Animal Experimentation

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

(2014) Phillip M. Rappold et al.   Nature Communications

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants

(2013) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

(2013) Marcel Leist et al.   ARCHIVES OF TOXICOLOGY

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

(2012) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

(2012) Bastian Zimmer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

(2012) Nina V. Balmer et al.   HUMAN MOLECULAR GENETICS

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

(2011) Dominik Pöltl et al.   NEUROTOXICOLOGY

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

(2010) B Zimmer et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite

(2010) Stefan Schildknecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway

(2009) M. Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

(2009) Stefan Schildknecht et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY