Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

Food for Thought … on the real success of 3R approches

(2017) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

The dawning of a new age of toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Food for thought ... on animal tests

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Food for thought … on the evolution of toxicology and the phasing out of animal testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Critical evaluation of the use of dogs in biomedical research and testing in Europe

(2014) Nina Hasiwa   ALTEX-Alternatives to Animal Experimentation

Towards tailored assays for cell-based approaches to toxicity testing

(2014) Gian Paolo Rossini   ALTEX-Alternatives to Animal Experimentation

Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

(2014) Bas Blaauboer   ALTEX-Alternatives to Animal Experimentation

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

(2014) David Basketter   ALTEX-Alternatives to Animal Experimentation

Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Systems toxicology

(2014) Thomas HArtung   ALTEX-Alternatives to Animal Experimentation

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

(2014) Nina Hasiwa   ALTEX-Alternatives to Animal Experimentation

Animal models: Not close enough

(2012) Jocelyn Rice   NATURE

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

(2012) Marco Schlepütz et al.   PLoS One

REPRINT: International, Multicenter Randomized Preclinical Trials in Translational Stroke Research

(2012) Ulrich Dirnagl et al.   STROKE

Validation and quality control of replacement alternatives – current status and future challenges

(2012) Marcel Leist et al.   Toxicology Research

Immunomodulatory therapy for sepsis: an update

(2011) Eirini Christaki et al.   Expert Review of Anti-Infective Therapy

Preclinical studies of human disease: Time to take methodological quality seriously

(2011) H. Bart van der Worp et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Medical progress depends on animal models - doesn't it?

(2008) Robert AJ Matthews   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE