Matrix mechanics and regulation of the fibroblast phenotype

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Endoluminal Gingival Fibroblast Transfer Reduces the Size of Rabbit Carotid Aneurisms via Elastin Repair

(2012) Eric Durand et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Contractile Equilibration of Single Cells to Step Changes in Extracellular Stiffness

(2012) Ailey Crow et al.   BIOPHYSICAL JOURNAL

Ca2+ Pulses Control Local Cycles of Lamellipodia Retraction and Adhesion along the Front of Migrating Cells

(2012) Feng-Chiao Tsai et al.   CURRENT BIOLOGY

Innovative antifibrotic therapies in systemic sclerosis

(2012) Christian Beyer et al.   CURRENT OPINION IN RHEUMATOLOGY

Mechanoregulation of cytoskeletal dynamics by TRP channels

(2012) Arthur J. Kuipers et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

(2012) Marilyn M. Giacomini et al.   EXPERIMENTAL CELL RESEARCH

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Oral Mucosa and Gingiva

(2012) Q.Z. Zhang et al.   JOURNAL OF DENTAL RESEARCH

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis

(2012) Keiko Iwaisako et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms

(2012) Mariya T. Sweetwyne et al.   MATRIX BIOLOGY

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Clinical utility of stem cells for periodontal regeneration

(2012) Kim Hynes et al.   PERIODONTOLOGY 2000

Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma

(2012) Shannon Kidd et al.   PLoS One

Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus

(2012) Huan Wang et al.   PLoS One

Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

(2012) L. Trichet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

(2011) Harold A. Chapman   Annual Review of Physiology

Myofibroblast-Mediated Adventitial Remodeling

(2011) Matteo Coen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Striated Acto-Myosin Fibers Can Reorganize and Register in Response to Elastic Interactions with the Matrix

(2011) Benjamin M. Friedrich et al.   BIOPHYSICAL JOURNAL

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

(2011) Paolo Cirri et al.   CANCER AND METASTASIS REVIEWS

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

(2011) H. E. Barker et al.   CANCER RESEARCH

Matrix control of scarring

(2011) Cecelia C. Yates et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

More than a feeling: discovering, understanding, and influencing mechanosensing pathways

(2011) Andrew W Holle et al.   CURRENT OPINION IN BIOTECHNOLOGY

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Fibroblasts and myofibroblasts in renal fibrosis

(2011) Soma Meran et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Analytically determined mechanical properties of, and models for the periodontal ligament: Critical review of literature

(2011) Ted S. Fill et al.   JOURNAL OF BIOMECHANICS

Cardiac Fibroblasts in Cell Culture Systems: Myofibroblasts All Along?

(2011) Stephan Rohr   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

(2011) Kimihide Hayakawa et al.   JOURNAL OF CELL BIOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation

(2011) Beverly J. Crider et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanical Load Induces a 100-Fold Increase in the Rate of Collagen Proteolysis by MMP-1

(2011) Arjun S. Adhikari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition

(2011) Susan E. Quaggin et al.   KIDNEY INTERNATIONAL

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism

(2011) Fen Guo et al.   PLoS One

Cellular/extracellular matrix cross-talk in scar evolution and control

(2011) Alan D. Widgerow   WOUND REPAIR AND REGENERATION

Matrix elasticity in vitro controls muscle stem cell fate in vivo

(2011) Matthew Raab et al.   Stem Cell Research & Therapy

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Cell Motility and Mechanics in Three-Dimensional Collagen Matrices

(2010) Frederick Grinnell et al.   Annual Review of Cell and Developmental Biology

Fibrogenic Reactions in Lung Disease

(2010) Jun Araya et al.   Annual Review of Pathology-Mechanisms of Disease

The biomechanical characteristics of the bone-periodontal ligament-cementum complex

(2010) Sunita P. Ho et al.   BIOMATERIALS

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro

(2010) Jennifer L. Young et al.   BIOMATERIALS

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions

(2010) Takeshi Kobayashi et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

(2010) Lysianne Follonier Castella et al.   EXPERIMENTAL CELL RESEARCH

Fibrocytes in health and disease

(2010) Erica L. Herzog et al.   EXPERIMENTAL HEMATOLOGY

The molecular mediators of type 2 epithelial to mesenchymal transition (EMT) and their role in renal pathophysiology

(2010) Wendy C. Burns et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

(2010) András Masszi et al.   JOURNAL OF CELL BIOLOGY

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

(2010) A. Buxboim et al.   JOURNAL OF CELL SCIENCE

A new lock-step mechanism of matrix remodelling based on subcellular contractile events

(2010) L. F. Castella et al.   JOURNAL OF CELL SCIENCE

The origin of fibroblasts and mechanism of cardiac fibrosis

(2010) Guido Krenning et al.   JOURNAL OF CELLULAR PHYSIOLOGY

‘Young’ Oral Fibroblasts Are Geno/Phenotypically Distinct

(2010) S. Enoch et al.   JOURNAL OF DENTAL RESEARCH

Future treatments in systemic sclerosis

(2010) Yoshihide ASANO   JOURNAL OF DERMATOLOGY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Subpopulations of fetal-like gingival fibroblasts: characterisation and potential significance for wound healing and the progression of periodontal disease

(2010) SL Schor et al.   ORAL DISEASES

Mechanical Strain Stabilizes Reconstituted Collagen Fibrils against Enzymatic Degradation by Mammalian Collagenase Matrix Metalloproteinase 8 (MMP-8)

(2010) Brendan P. Flynn et al.   PLoS One

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

A Multipotent Neural Crest-Derived Progenitor Cell Population Is Resident Within the Oral Mucosa Lamina Propria

(2010) Lindsay C. Davies et al.   STEM CELLS AND DEVELOPMENT

Multipotent Progenitor Cells in Gingival Connective Tissue

(2010) Benjamin P.J. Fournier et al.   TISSUE ENGINEERING PART A

Integrin-Mediated Transforming Growth Factor-β Activation, a Potential Therapeutic Target in Fibrogenic Disorders

(2009) Stephen L. Nishimura   AMERICAN JOURNAL OF PATHOLOGY

Emerging Concepts in the Pathogenesis of Lung Fibrosis

(2009) William D. Hardie et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Biomechanics: Cell Research and Applications for the Next Decade

(2009) Dennis Discher et al.   ANNALS OF BIOMEDICAL ENGINEERING

Cell Mechanics: Dissecting the Physical Responses of Cells to Force

(2009) Brenton D. Hoffman et al.   Annual Review of Biomedical Engineering

Vascular Smooth Muscle Cell Durotaxis Depends on Substrate Stiffness Gradient Strength

(2009) Brett C. Isenberg et al.   BIOPHYSICAL JOURNAL

Mesenchymal Stem Cells: Flip Side of the Coin

(2009) Pravin J. Mishra et al.   CANCER RESEARCH

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Extracellular microfibrils: contextual platforms for TGFβ and BMP signaling

(2009) Francesco Ramirez et al.   CURRENT OPINION IN CELL BIOLOGY

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

(2009) Viola Vogel et al.   CURRENT OPINION IN CELL BIOLOGY

Myofibroblasts in diseased hearts: New players in cardiac arrhythmias?

(2009) Stephan Rohr   HEART RHYTHM

Portal fibroblasts: Underappreciated mediators of biliary fibrosis

(2009) Jonathan A. Dranoff et al.   HEPATOLOGY

Latent Transforming Growth Factor β-binding Proteins and Fibulins Compete for Fibrillin-1 and Exhibit Exquisite Specificities in Binding Sites

(2009) Robert N. Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D

(2009) Fitzroy J. Byfield et al.   JOURNAL OF BIOMECHANICS

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

On a Path to Unfolding the Biological Mechanisms of Orthodontic Tooth Movement

(2009) V. Krishnan et al.   JOURNAL OF DENTAL RESEARCH

Gingival and periodontal ligament fibroblasts differ in their inflammatory response to viablePorphyromonas gingivalis

(2009) N. Scheres et al.   JOURNAL OF PERIODONTAL RESEARCH

Calcium flickers steer cell migration

(2009) Chaoliang Wei et al.   NATURE

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Fibroblast activation and myofibroblast generation in obstructive nephropathy

(2009) María T. Grande et al.   Nature Reviews Nephrology

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

The hard life of soft cells

(2009) Paul A. Janmey et al.   CELL MOTILITY AND THE CYTOSKELETON

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Healing of Periodontal Tissues Following Transplantation of Cells in a Rat Orthodontic Tooth Movement Model

(2008) Bob N. Nayak et al.   ANGLE ORTHODONTIST

Substrate Stiffness Affects the Functional Maturation of Neonatal Rat Ventricular Myocytes

(2008) Jeffrey G. Jacot et al.   BIOPHYSICAL JOURNAL

Diversity of Fibroblasts – A Review on Implications for Skin Tissue Engineering

(2008) Sonja Veronika Nolte et al.   CELLS TISSUES ORGANS

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL

(2008) Stephane Mouilleron et al.   EMBO JOURNAL

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mechanobiology of tooth movement

(2008) S. Henneman et al.   EUROPEAN JOURNAL OF ORTHODONTICS

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Stromal myofibroblasts are drivers of invasive cancer growth

(2008) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF CANCER

Myofibroblast communication is controlled by intercellular mechanical coupling

(2008) L. Follonier et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction - a field pulling together?

(2008) C. S. Chen   JOURNAL OF CELL SCIENCE

Actin stress fibers transmit and focus force to activate mechanosensitive channels

(2008) Kimihide Hayakawa et al.   JOURNAL OF CELL SCIENCE

Deep dermal fibroblasts contribute to hypertrophic scarring

(2008) JianFei Wang et al.   LABORATORY INVESTIGATION

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair

(2008) J IREDALE   PHARMACOLOGICAL RESEARCH

Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli

(2008) Jessamine P. Winer et al.   TISSUE ENGINEERING PART A

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Development of a multipotent clonal human periodontal ligament cell line

(2007) Atsushi Tomokiyo et al.   DIFFERENTIATION