The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Patterns of Clinical Response to Eculizumab in Patients With C3 Glomerulopathy

(2018) Moglie Le Quintrec et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection

(2018) Grecia M. Marrón-Liñares et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Blocking Properdin Prevents Complement-Mediated Hemolytic Uremic Syndrome and Systemic Thrombophilia

(2018) Yoshiyasu Ueda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy

(2018) Andrew S. Bomback et al.   KIDNEY INTERNATIONAL

C5 inhibition prevents renal failure in a mouse model of lethal C3 glomerulopathy

(2017) Allison Lesher Williams et al.   KIDNEY INTERNATIONAL

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies

(2017) Maria-Chiara Marinozzi et al.   KIDNEY INTERNATIONAL

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

Properdin binding to complement activating surfaces depends on initial C3b deposition

(2017) Morten Harboe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospective observational study in two Dutch hospitals to assess the performance of inflammatory plasma markers to determine disease severity of viral respiratory tract infections in children

(2017) Inge M L Ahout et al.   BMJ Open

The alternative complement pathway is dysregulated in patients with chronic heart failure

(2017) Negar Shahini et al.   Scientific Reports

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy

(2016) F. Corvillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Properdin: a tightly regulated critical inflammatory modulator

(2016) Adam Z. Blatt et al.   IMMUNOLOGICAL REVIEWS

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

(2016) Adam Z. Blatt et al.   JOURNAL OF IMMUNOLOGY

Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients

(2016) Felix Poppelaars et al.   Journal of Translational Medicine

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

(2016) Paraskevas Iatropoulos et al.   MOLECULAR IMMUNOLOGY

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

C3 Glomerulopathy

(2016) Magdalena Riedl et al.   PEDIATRIC NEPHROLOGY

The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes

(2016) Elisabeth Hertle et al.   THROMBOSIS AND HAEMOSTASIS

Properdin levels in individuals with chemotherapy-induced neutropenia

(2016) Artsiom Tsyrkunou et al.   Open Forum Infectious Diseases

Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015

(2015) Marina Noris et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

(2015) Evelien T. M. Berends et al.   BMC BIOLOGY

Properdin Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene–Deficient Mice

(2015) Umang Jain et al.   INFLAMMATORY BOWEL DISEASES

Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation

(2015) Yuan Wang et al.   JOURNAL OF IMMUNOLOGY

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation

(2015) Ádám I. Csincsi et al.   JOURNAL OF IMMUNOLOGY

Properdin Provides Protection fromCitrobacter rodentium–Induced Intestinal Inflammation in a C5a/IL-6–Dependent Manner

(2015) Umang Jain et al.   JOURNAL OF IMMUNOLOGY

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

(2015) Q. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effectiveness of mycophenolate mofetil in C3 glomerulonephritis

(2015) Cristina Rabasco et al.   KIDNEY INTERNATIONAL

The role of complement in C3 glomerulopathy

(2015) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

Defining the Complement Biomarker Profile of C3 Glomerulopathy

(2014) Y. Zhang et al.   Clinical Journal of the American Society of Nephrology

Properdin Deficiency in Murine Models of Nonseptic Shock

(2014) N. D. Ivanovska et al.   JOURNAL OF IMMUNOLOGY

Properdin Plays a Protective Role in Polymicrobial Septic Peritonitis

(2014) C. M. Stover et al.   JOURNAL OF IMMUNOLOGY

Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation

(2014) W. Xu et al.   JOURNAL OF IMMUNOLOGY

Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia–reperfusion injury

(2014) Jing Miao et al.   KIDNEY INTERNATIONAL

Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin

(2014) Aline Dupont et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach

(2014) Anete Sevciovic Grumach et al.   MOLECULAR IMMUNOLOGY

Syndromes of Thrombotic Microangiopathy

(2014) James N. George et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples

(2014) Diana Pauly et al.   PLoS One

Complement Profile in Neonates of Different Gestational Ages

(2014) A. S. Grumach et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Treatment of C3 Glomerulopathy with Complement Blockers

(2014) Francesco Emma et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage

(2014) Seiji Nagamachi et al.   BMC Nephrology

Genetics and Outcome of Atypical Hemolytic Uremic Syndrome: A Nationwide French Series Comparing Children and Adults

(2013) V. Fremeaux-Bacchi et al.   Clinical Journal of the American Society of Nephrology

C3 Glomerulopathy: Clinicopathologic Features and Predictors of Outcome

(2013) N. R. Medjeral-Thomas et al.   Clinical Journal of the American Society of Nephrology

Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)

(2013) G. Saggu et al.   JOURNAL OF IMMUNOLOGY

Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

(2013) T. Miwa et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase Directs Properdin-Mediated Complement Activation

(2013) Joseph O'Flynn et al.   Journal of Innate Immunity

C3 glomerulopathy: consensus report

(2013) Matthew C. Pickering et al.   KIDNEY INTERNATIONAL

Properdin in complement activation and tissue injury

(2013) Allison M. Lesher et al.   MOLECULAR IMMUNOLOGY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

(2013) M. Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

Complement Factor H-Related Protein 1 Deficiency and Factor H Antibodies in Pediatric Patients with Atypical Hemolytic Uremic Syndrome

(2012) J. Hofer et al.   Clinical Journal of the American Society of Nephrology

Elevated Properdin and Enhanced Complement Activation in First-Degree Relatives of South Asian Subjects With Type 2 Diabetes

(2012) R. Somani et al.   DIABETES CARE

Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate

(2012) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

(2012) Mario Hebecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation

(2012) M. Harboe et al.   JOURNAL OF IMMUNOLOGY

Unexpected Role for Properdin in Complement C3 Glomerulopathies

(2012) M. R. Daha   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Combination of Factor H Mutation and Properdin Deficiency Causes Severe C3 Glomerulonephritis

(2012) A. M. Lesher et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Properdin Exacerbates C3 Glomerulopathy Resulting from Factor H Deficiency

(2012) M. M. Ruseva et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies

(2012) Aude Servais et al.   KIDNEY INTERNATIONAL

Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation

(2012) Danielle Paixão-Cavalcante et al.   KIDNEY INTERNATIONAL

Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody–associated vasculitis

(2012) Shen-Ju Gou et al.   KIDNEY INTERNATIONAL

Monitoring and modeling treatment of atypical hemolytic uremic syndrome

(2012) Stefan Heinen et al.   MOLECULAR IMMUNOLOGY

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

(2012) Julien Zuber et al.   Nature Reviews Nephrology

Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm

(2012) H.-f. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mutation W388X Underlying Properdin Deficiency in a Finnish Family

(2012) M. Helminen et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis

(2012) Petya Dimitrova et al.   ARTHRITIS RESEARCH & THERAPY

Clinical features and outcomes of 98 children and adults with dense deposit disease

(2011) Der-Fa Lu et al.   PEDIATRIC NEPHROLOGY

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

(2011) S. Agarwal et al.   mBio

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

(2010) M. Noris et al.   Clinical Journal of the American Society of Nephrology

Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome

(2010) Tara K. Maga et al.   HUMAN MUTATION

Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement

(2010) Viviana P. Ferreira et al.   IMMUNOBIOLOGY

Native Properdin Binds toChlamydia pneumoniaeand Promotes Complement Activation

(2010) Claudio Cortes et al.   INFECTION AND IMMUNITY

Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

(2010) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury

(2010) Yuko Kimura et al.   JOURNAL OF CLINICAL INVESTIGATION

An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae

(2010) S. Agarwal et al.   JOURNAL OF IMMUNOLOGY

The role of properdin in murine zymosan-induced arthritis

(2010) Petya Dimitrova et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Properdin deficiency associated with recurrent otitis media and pneumonia, and identification of male carrier with Klinefelter syndrome

(2009) Lone Schejbel et al.   CLINICAL IMMUNOLOGY

Urinary properdin excretion is associated with intrarenal complement activation and poor renal function

(2009) M. A. Siezenga et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Atypical Hemolytic–Uremic Syndrome

(2009) Marina Noris et al.   NEW ENGLAND JOURNAL OF MEDICINE

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS

FDA Report: Eculizumab (Soliris(R)) for the Treatment of Patients with Paroxysmal Nocturnal Hemoglobinuria

(2008) A. Dmytrijuk et al.   ONCOLOGIST

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

(2008) Claudia Kemper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement

(2007) Y. Kimura et al.   BLOOD