Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis

Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives

(2014) Robert J. Fontana   GASTROENTEROLOGY

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

(2014) Irene Locatelli et al.   HEPATOLOGY

Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC

(2014) Xiaolu Zhai et al.   MEDICAL ONCOLOGY

Transcriptional profiling and co-expression network analysis identifies potential biomarkers to differentiate chronic hepatitis B and the caused cirrhosis

(2014) Yi-Yu Lu et al.   Molecular BioSystems

Open TG-GATEs: a large-scale toxicogenomics database

(2014) Yoshinobu Igarashi et al.   NUCLEIC ACIDS RESEARCH

Characterization of Chemically Induced Liver Injuries Using Gene Co-Expression Modules

(2014) Gregory J. Tawa et al.   PLoS One

Systems Level Analysis and Identification of Pathways and Networks Associated with Liver Fibrosis

(2014) Mohamed Diwan M. AbdulHameed et al.   PLoS One

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury

(2013) Maryna Perepelyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies

(2013) Aleksandar Sokolović et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis

(2013) Erawan Borkham-Kamphorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis

(2013) Han Kyoung Choi et al.   CELL RESEARCH

The current status of biomarkers for predicting toxicity

(2013) Sarah Campion et al.   Expert Opinion on Drug Metabolism & Toxicology

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone

(2013) Yie Hou Lee et al.   JOURNAL OF PROTEOME RESEARCH

Integrated Glycoproteomics Demonstrates Fucosylated Serum Paraoxonase 1 Alterations in Small Cell Lung Cancer

(2013) Jung-Mo Ahn et al.   MOLECULAR & CELLULAR PROTEOMICS

Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

(2013) J D Zhang et al.   PHARMACOGENOMICS JOURNAL

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Interferon-Gamma Directly Mediates Developmental Biliary Defects

(2013) Shuang Cui et al.   Zebrafish

Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat

(2012) Jeannie Chan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility

(2012) A Alfirevic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Efficient key pathway mining: combining networks and OMICS data

(2012) Nicolas Alcaraz et al.   Integrative Biology

Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

(2012) Mo Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipocalin2 Promotes Invasion, Tumorigenicity and Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

(2012) Lisa Leung et al.   PLoS One

Anchoring Hepatic Gene Expression with Development of Fibrosis and Neoplasia in a Toxicant-induced Fish Model of Liver Injury

(2012) Arnaud J. Van Wettere et al.   TOXICOLOGIC PATHOLOGY

Non-Invasive markers for hepatic fibrosis

(2011) Ancha Baranova et al.   BMC GASTROENTEROLOGY

PAI-1 in tissue fibrosis

(2011) Asish K. Ghosh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia–reperfusion injury in a swine hemorrhagic shock model

(2011) Marlin Wayne Causey et al.   JOURNAL OF VASCULAR SURGERY

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Potential candidate genomic biomarkers of drug induced vascular injury in the rat

(2011) Deidre A. Dalmas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Different effects of the probe summarization algorithms PLIER and RMA on high-level analysis of Affymetrix exon arrays

(2010) Yi Qu et al.   BMC BIOINFORMATICS

Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor

(2010) Tsutomu Fujii et al.   BMC GASTROENTEROLOGY

The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair

(2010) Bing Li et al.   FASEB JOURNAL

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2)

(2010) Guangcun Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

(2010) Yuxia Cui et al.   PHARMACOGENOMICS

Increased Urinary Lipocalin-2 Reflects Matrix Metalloproteinase-9 Activity in Chronic Hepatitis C with Hepatic Fibrosis

(2010) Jin-Wook Kim et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

(2010) Bob Thoolen et al.   TOXICOLOGIC PATHOLOGY

The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity

(2010) David E. Amacher   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differential cellular expression of FXYD1 (phospholemman) and FXYD2 (gamma subunit of Na, K-ATPase) in normal human tissues: A study using high density human tissue microarrays

(2009) Rachel V. Floyd et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

S100A4 mediates endometrial cancer invasion and is a target of TGF-β1 signaling

(2009) Ran Xie et al.   LABORATORY INVESTIGATION

Protective effect of bicyclol on tetracycline-induced fatty liver in mice

(2009) Hong-Yan Yu et al.   TOXICOLOGY

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

(2009) Richard D. Beger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

The Early Effects of Short-Term Dexamethasone Administration on Hepatic and Serum Alanine Aminotransferase in the Rat

(2008) Elisa R. Jackson et al.   DRUG AND CHEMICAL TOXICOLOGY

Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity

(2008) Alison Hege Harrill et al.   Expert Opinion on Drug Metabolism & Toxicology

Transgelin is a direct target of TGF-β/Smad3-dependent epithelial cell migration in lung fibrosis

(2008) Haiying Yu et al.   FASEB JOURNAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Detection of novel biomarkers of liver cirrhosis by proteomic analysis

(2008) Christian Mölleken et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Oxidative Stress, Plasminogen Activator Inhibitor 1, and Lung Fibrosis

(2007) Rui-Ming Liu   ANTIOXIDANTS & REDOX SIGNALING

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY