Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity

Toxicodynamic Therapeutic Drug Monitoring of Immunosuppressants: Promises, Reality, and Challenges

(2009) Uwe Christians et al.   THERAPEUTIC DRUG MONITORING

What Does Systems Biology Mean for Drug Development?

(2008) Andre Schrattenholz et al.   CURRENT MEDICINAL CHEMISTRY

From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions

(2008) Daniel W. Nebert et al.   DRUG METABOLISM REVIEWS

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans

(2008) T Uehara et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Creating and evaluating genetic tests predictive of drug response

(2008) Scott T. Weiss et al.   NATURE REVIEWS DRUG DISCOVERY

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discriminating the molecular basis of hepatotoxicity using the large-scale characteristic molecular signatures of toxicants by expression profiling analysis

(2008) Jung Woo Eun et al.   TOXICOLOGY

Validation of putative genomic biomarkers of nephrotoxicity in rats

(2008) Er-Jia Wang et al.   TOXICOLOGY

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Expression profile of liver genes in response to hepatotoxicants identified using a SAGE-based customized DNA microarray system

(2007) Hidekuni Inadera et al.   TOXICOLOGY LETTERS