The role of orexin in motivated behaviours

Dorsal Raphe Neurons Signal Reward through 5-HT and Glutamate

(2014) Zhixiang Liu et al.   NEURON

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

(2014) Keishi Etori et al.   Frontiers in Neuroscience

Orexin/hypocretin receptor signalling: a functional perspective

(2013) C S Leonard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin/hypocretin receptor signalling cascades

(2013) J P Kukkonen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

(2013) Michel A. Steiner et al.   ChemMedChem

Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory Consolidation

(2013) S. Soya et al.   JOURNAL OF NEUROSCIENCE

A Role for Hypocretin/Orexin Receptor-1 in Cue-Induced Reinstatement of Nicotine-Seeking Behavior

(2013) Ainhoa Plaza-Zabala et al.   NEUROPSYCHOPHARMACOLOGY

Co-localization of hypocretin-1 and leucine-enkephalin in hypothalamic neurons projecting to the nucleus of the solitary tract and their effect on arterial pressure

(2013) J. Ciriello et al.   NEUROSCIENCE

High and low activity rats: Elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred rats

(2013) Claudio E. Perez-Leighton et al.   Obesity

Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus

(2013) R. M. Sears et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits

(2013) N. Nisimaru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction

(2013) Ashley M. Blouin et al.   Nature Communications

Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses

(2012) Kamon Iigaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking

(2012) Rachel J. Smith et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

(2012) G. C. Sartor et al.   JOURNAL OF NEUROSCIENCE

Lateral Hypothalamic Orexin/Hypocretin Neurons That Project to Ventral Tegmental Area Are Differentially Activated with Morphine Preference

(2012) K. A. Richardson et al.   JOURNAL OF NEUROSCIENCE

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

(2012) Mitsuko Watabe-Uchida et al.   NEURON

Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats

(2012) G.D. Petrovich et al.   NEUROSCIENCE

Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network

(2012) Philip L. Johnson et al.   PHYSIOLOGY & BEHAVIOR

The brain orexin system and almorexant in fear-conditioned startle reactions in the rat

(2012) Michel A. Steiner et al.   PSYCHOPHARMACOLOGY

Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?

(2012) Rémi Martin-Fardon et al.   Frontiers in Behavioral Neuroscience

Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward

(2011) Daniel M. Hutcheson et al.   BEHAVIOURAL PHARMACOLOGY

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

(2011) Tatsuhiko Fujimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex

(2011) Israt Z Shahid et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking

(2011) Morgan H. James et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep

(2011) M. Mieda et al.   JOURNAL OF NEUROSCIENCE

Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels

(2011) Anne Venner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

(2011) Mahesh M. Karnani et al.   NEURON

Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists

(2011) Alessandro Gozzi et al.   PLoS One

Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

(2011) T. Mochizuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

(2011) Takeshi Sakurai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement

(2010) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin1 receptors

(2010) B Jupp et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disposition and Metabolism of [14C]SB-649868, an Orexin 1 and 2 Receptor Antagonist, in Humans

(2010) C. Renzulli et al.   DRUG METABOLISM AND DISPOSITION

Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats

(2010) Andrea R. Di Sebastiano et al.   HORMONES AND BEHAVIOR

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Orexins Depolarize Rostral Ventrolateral Medulla Neurons and Increase Arterial Pressure and Heart Rate in Rats Mainly via Orexin 2 Receptors

(2010) S.-C. Huang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Orexin neurons are indispensable for stress-induced thermogenesis in mice

(2010) Wei Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mapping the Binding Pocket of Dual Antagonist Almorexant to Human Orexin 1 and Orexin 2 Receptors: Comparison with the Selective OX1 Antagonist SB-674042 and the Selective OX2 Antagonist N-Ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA)

(2010) P. Malherbe et al.   MOLECULAR PHARMACOLOGY

The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats

(2010) D.L. Choi et al.   NEUROSCIENCE

Hypocretin-1 (orexin A) prevents the effects of hypoxia/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus

(2010) O. Dergacheva et al.   NEUROSCIENCE

Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity

(2010) Angie M. Cason et al.   PHYSIOLOGY & BEHAVIOR

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA

(2010) Mark G. LeSage et al.   PSYCHOPHARMACOLOGY

Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

(2010) James R. Shoblock et al.   PSYCHOPHARMACOLOGY

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration

(2010) Rodrigo A. España et al.   PSYCHOPHARMACOLOGY

Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol–preferring Sprague–Dawley rats

(2009) David E. Moorman et al.   ALCOHOL

Abnormal activity in reward brain circuits in human narcolepsy with cataplexy

(2009) Aurélie Ponz et al.   ANNALS OF NEUROLOGY

Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis

(2009) Wei Zhang et al.   BRAIN RESEARCH

Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction

(2009) Stephanie L. Borgland et al.   BRAIN RESEARCH

Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization

(2009) Ruth Sharf et al.   BRAIN RESEARCH

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction

(2009) Gary Aston-Jones et al.   BRAIN RESEARCH

Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

(2009) Tetsuya Shiuchi et al.   Cell Metabolism

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

(2009) Hiromasa Funato et al.   Cell Metabolism

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

(2009) Teri M. Furlong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking

(2009) Rachel J. Smith et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

(2009) Rodrigo A. España et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness

(2009) Mirela Barros Dias et al.   JOURNAL OF PHYSIOLOGY-LONDON

A key role for orexin in panic anxiety

(2009) Philip L Johnson et al.   NATURE MEDICINE

The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization

(2009) Davide Quarta et al.   NEUROCHEMISTRY INTERNATIONAL

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

(2009) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Orexin/hypocretin is necessary for context-driven cocaine-seeking

(2009) Rachel J. Smith et al.   NEUROPHARMACOLOGY

Obstructive sleep apnea in narcolepsy

(2009) Gemma Sansa et al.   SLEEP MEDICINE

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

(2008) S G Nair et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin-A Hyperphagia: Hindbrain Participation in Consummatory Feeding Responses

(2008) John-Paul Baird et al.   ENDOCRINOLOGY

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin  -Opioid System

(2008) B. B. Land et al.   JOURNAL OF NEUROSCIENCE

A Role for Brain Stress Systems in Addiction

(2008) George F. Koob   NEURON

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY

Insular hypocretin transmission regulates nicotine reward

(2008) J. A. Hollander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse

(2007) Christopher V. Dayas et al.   BIOLOGICAL PSYCHIATRY

Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder

(2007) J. R. Strawn et al.   DEPRESSION AND ANXIETY

The orexin system regulates alcohol-seeking in rats

(2006) Andrew J Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY