Orexin/hypocretin receptor signalling cascades

The hypocretins/orexins: integrators of multiple physiological functions

(2013) Jingcheng Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Overview

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin/hypocretin receptor signalling: a functional perspective

(2013) C S Leonard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

(2013) C J Winrow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012

(2012) Jyrki P. Kukkonen   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes

(2012) M. Skrzypski et al.   FEBS LETTERS

Orexinergic modulation of GABAergic neurotransmission to cardiac vagal neurons in the brain stem nucleus ambiguus changes during development

(2012) O. Dergacheva et al.   NEUROSCIENCE

The closing and opening of TRPC channels by Homer1 and STIM1

(2011) J. P. Yuan et al.   Acta Physiologica

The orexin OX1receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

(2011) Tian-Rui Xu et al.   BIOCHEMICAL JOURNAL

OX1orexin/hypocretin receptor activation of phospholipase D

(2011) MH Jäntti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis

(2011) T. Voisin et al.   CANCER RESEARCH

A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels

(2011) Jyrki P. Kukkonen   CELL CALCIUM

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

(2011) Dyan Sellayah et al.   Cell Metabolism

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes

(2011) M. Skrzypski et al.   DIABETOLOGIA

Heteromultimerization of Cannabinoid CB1Receptor and Orexin OX1Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A

(2011) Richard J. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Orexin 1 Receptors in the Periaqueductal Gray of Male Rats Leads to Antinociception via Retrograde Endocannabinoid (2-Arachidonoylglycerol)-Induced Disinhibition

(2011) Y.-C. Ho et al.   JOURNAL OF NEUROSCIENCE

Probing the regulation of TASK potassium channels by PI(4,5)P2with switchable phosphoinositide phosphatases

(2011) Moritz Lindner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscular effects of orexin A on the mouse duodenum: mechanical and electrophysiological studies

(2011) Roberta Squecco et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Role for Orexin in Central Vestibular Motor Control

(2011) Jun Zhang et al.   NEURON

Agonist ligand discrimination by the two orexin receptors depends on the expression system

(2011) Jaana Putula et al.   NEUROSCIENCE LETTERS

Mapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras

(2011) Jaana Putula et al.   NEUROSCIENCE LETTERS

Dynein Light Chain Tctex-Type 1 Modulates Orexin Signaling through Its Interaction with Orexin 1 Receptor

(2011) David Duguay et al.   PLoS One

Spatial organization of intracellular Ca2+ signals

(2011) Vera Konieczny et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

(2011) Supachoke Mangmool et al.   Toxins

A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation

(2010) Hanna M. Peltonen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ligand-induced internalization of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging

(2010) Richard J Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway

(2010) Lauri M. Louhivuori et al.   CELL CALCIUM

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons

(2010) M. Kalogiannis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Muscarinic Acetylcholine Receptors (mAChRs) in the Nervous System: Some Functions and Mechanisms

(2010) David A. Brown   JOURNAL OF MOLECULAR NEUROSCIENCE

Ca2+-Dependent and Na+-Dependent K+ Conductances Contribute to a Slow AHP in Thalamic Paraventricular Nucleus Neurons: A Novel Target for Orexin Receptors

(2010) Li Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling

(2010) M. Gees et al.   Cold Spring Harbor Perspectives in Biology

Rapid and easy semi-quantitative evaluation method for diacylglycerol and inositol-1,4,5-trisphosphate generation in orexin receptor signalling

(2009) M. E. Ekholm et al.   Acta Physiologica

Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases

(2009) O. Selbach et al.   Acta Physiologica

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells

(2009) Jan Wenzel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Involvement of TRPC3 channels in calcium oscillations mediated by OX1 orexin receptors

(2009) Hanna M. Peltonen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arachidonic acid release mediated by OX1 orexin receptors

(2009) Pauli M Turunen et al.   BRITISH JOURNAL OF PHARMACOLOGY

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

(2009) Graeme Milligan   BRITISH JOURNAL OF PHARMACOLOGY

Arachidonic acid, ARC channels, and Orai proteins

(2009) Trevor J. Shuttleworth   CELL CALCIUM

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis

(2009) Aadil El Firar et al.   FASEB JOURNAL

Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B

(2009) Manjunath Ramanjaneya et al.   JOURNAL OF ENDOCRINOLOGY

Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

(2009) C. Acuna-Goycolea et al.   JOURNAL OF NEUROSCIENCE

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypocretin-1/orexin-A activates subfornical organ neurons of rats

(2009) Kentaro Ono et al.   NEUROREPORT

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Orexin-A increases cell surface expression of AMPA receptors in the striatum

(2008) Hyun Sung Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple phospholipase activation by OX1 orexin/hypocretin receptors

(2008) L. Johansson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The signalling profile of recombinant human orexin-2 receptor

(2008) Jiyou Tang et al.   CELLULAR SIGNALLING

Orexins Stimulate Steroidogenic Acute Regulatory Protein Expression through Multiple Signaling Pathways in Human Adrenal H295R Cells

(2008) Manjunath Ramanjaneya et al.   ENDOCRINOLOGY

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

(2008) S. L. Borgland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism

(2008) Thierry Voisin et al.   FASEB JOURNAL

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca2+ Transients Mediated by L-Type Calcium Channels

(2008) K. A. Kohlmeier et al.   JOURNAL OF NEUROPHYSIOLOGY

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

(2008) W. Su et al.   MOLECULAR PHARMACOLOGY

Acid-sensitive TASK-like K+ conductances contribute to resting membrane potential and to orexin-induced membrane depolarization in rat thalamic paraventricular nucleus neurons

(2008) P. Doroshenko et al.   NEUROSCIENCE

Orexin-A Inhibits Glucagon Secretion and Gene Expression through a Foxo1-Dependent Pathway

(2007) Eva Göncz et al.   ENDOCRINOLOGY

Regulation of OX1 orexin/hypocretin receptor-coupling to phospholipase C by Ca2+ influx

(2006) L Johansson et al.   BRITISH JOURNAL OF PHARMACOLOGY