Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking

The orexin1 receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats

(2011) Bianca Jupp et al.   BRAIN RESEARCH

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking

(2011) Morgan H. James et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement

(2010) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin1 receptors

(2010) B Jupp et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats

(2010) D.L. Choi et al.   NEUROSCIENCE

Tobacco dependence, the insular cortex and the hypocretin connection

(2010) Paul J. Kenny   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity

(2010) Angie M. Cason et al.   PHYSIOLOGY & BEHAVIOR

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA

(2010) Mark G. LeSage et al.   PSYCHOPHARMACOLOGY

Involvement of the orexin/hypocretin system in ethanol conditioned place preference

(2010) Charlene M. Voorhees et al.   PSYCHOPHARMACOLOGY

Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol–preferring Sprague–Dawley rats

(2009) David E. Moorman et al.   ALCOHOL

Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction

(2009) Stephanie L. Borgland et al.   BRAIN RESEARCH

Role of orexin/hypocretin in dependence and addiction

(2009) Ruth Sharf et al.   BRAIN RESEARCH

Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin

(2009) Rémi Martin-Fardon et al.   BRAIN RESEARCH

Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization

(2009) Ruth Sharf et al.   BRAIN RESEARCH

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction

(2009) Gary Aston-Jones et al.   BRAIN RESEARCH

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking

(2009) Rachel J. Smith et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

(2009) Rodrigo A. España et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dopamine D1 receptor antagonism in the prelimbic cortex blocks the reinstatement of heroin-seeking in an animal model of relapse

(2009) Ronald E. See   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Orexin/hypocretin is necessary for context-driven cocaine-seeking

(2009) Rachel J. Smith et al.   NEUROPHARMACOLOGY

Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

(2008) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

(2008) S G Nair et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking

(2008) R. T. LaLumiere et al.   JOURNAL OF NEUROSCIENCE

Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system

(2008) Antonello Bonci et al.   NEUROPHARMACOLOGY

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY

Insular hypocretin transmission regulates nicotine reward

(2008) J. A. Hollander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats

(2008) Jemma K. Richards et al.   PSYCHOPHARMACOLOGY

Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse

(2007) Christopher V. Dayas et al.   BIOLOGICAL PSYCHIATRY

The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse

(2007) J.L. Rogers et al.   NEUROSCIENCE

The orexin system regulates alcohol-seeking in rats

(2006) Andrew J Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY