Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

Orexin-1 receptor antagonism fails to reduce anxiety-like behaviour in either plus-maze-naïve or plus-maze-experienced mice

(2013) R.J. Rodgers et al.   BEHAVIOURAL BRAIN RESEARCH

Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone

(2012) Stephen R. Morairty et al.   PLoS One

The brain orexin system and almorexant in fear-conditioned startle reactions in the rat

(2012) Michel A. Steiner et al.   PSYCHOPHARMACOLOGY

The Orexin Antagonist SB-649868 Promotes and Maintains Sleep in Men with Primary Insomnia

(2012) Paolo Bettica et al.   SLEEP

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

(2011) Takeshi Sakurai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat

(2010) Michel A Steiner et al.   NEUROPSYCHOPHARMACOLOGY

Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

(2010) Hendrik Dietrich et al.   PSYCHOPHARMACOLOGY

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

(2009) Teri M. Furlong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orexin Receptor Antagonism: A New Principle in Neuroscience

(2008) Christoph Boss et al.   CHIMIA