New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy

Wild-type and mutant p53 proteins interact with mitochondrial caspase-3

(2011) Amanda K. Frank et al.   CANCER BIOLOGY & THERAPY

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

(2011) M. Wang et al.   CANCER RESEARCH

p21Cip1/WAF1mediates cyclin B1 degradation in response to DNA damage

(2011) Laura D. Gillis et al.   CELL CYCLE

p21WAF1is component of a positive feedback loop that maintains the p53 transcriptional program

(2011) Lisa Y. Pang et al.   CELL CYCLE

TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence

(2011) H. D. Skinner et al.   CLINICAL CANCER RESEARCH

TP53 Mutations in Nonsmall Cell Lung Cancer

(2011) Akira Mogi et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitization to γ-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells

(2010) Feng Zhang et al.   CANCER BIOLOGY & THERAPY

Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells

(2010) Alfredo Toschi et al.   CANCER LETTERS

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

(2010) H. Takai et al.   GENES & DEVELOPMENT

Clues from cell metabolism

(2010) William G. Kaelin et al.   NATURE

Autophagy, senescence and tumor dormancy in cancer therapy

(2009) David A. Gewirtz   Autophagy

A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells

(2009) Sylvia Mansilla et al.   BIOCHEMICAL PHARMACOLOGY

Mutant p53 mediates survival of breast cancer cells

(2009) L Y Lim et al.   BRITISH JOURNAL OF CANCER

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

(2009) F. Ianzini et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

The role of meiotic cohesin REC8 in chromosome segregation in γ irradiation-induced endopolyploid tumour cells

(2009) Jekaterina Erenpreisa et al.   EXPERIMENTAL CELL RESEARCH

BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy

(2009) Xiaoying Yin et al.   INTERNATIONAL JOURNAL OF CANCER

Single-cell analysis of p16INK4aand p21WAF1expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts

(2009) Razmik Mirzayans et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cell fate decision mediated by p53 pulses

(2009) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-Dose Radiation-Induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radioresistant

(2009) Kelvin K. C. Tsai et al.   RADIATION RESEARCH

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

(2008) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

(2008) Maciej Pietrzak et al.   BIOLOGICAL CHEMISTRY

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase

(2008) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

Histone Deacetylase Inhibition and Blockade of the Glycolytic Pathway Synergistically Induce Glioblastoma Cell Death

(2008) V. Egler et al.   CLINICAL CANCER RESEARCH

Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy

(2008) E. Crescenzi et al.   CLINICAL CANCER RESEARCH

Pharmacological Modulation of p53 Function in Cancer Therapy

(2008) Razmik Mirzayans et al.   Current Signal Transduction Therapy

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Altered gene expression in busulfan-resistant human myeloid leukemia

(2008) Benigno C. Valdez et al.   LEUKEMIA RESEARCH

Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells

(2008) Young-Gi Gil et al.   LIFE SCIENCES

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation

(2008) Wengang Cao et al.   PROSTATE

Ultraviolet light exposure triggers nuclear accumulation of p21WAF1and accelerated senescence in human normal and nucleotide excision repair-deficient fibroblast strains

(2007) Razmik Mirzayans et al.   JOURNAL OF CELLULAR PHYSIOLOGY