Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs

(2015)   Oncotarget

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

(2011) Muhan Chen et al.   CANCER CELL

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

(2010) Sarah E. Golding et al.   CANCER BIOLOGY & THERAPY

PI3K/Akt/mTOR Pathway Inhibitors in Cancer: A Perspective on Clinical Progress

(2010) P. Wu et al.   CURRENT MEDICINAL CHEMISTRY

The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation: A 2009 Update

(2010) Craig Lindsley   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Akt inhibitors in clinical development for the treatment of cancer

(2010) Sumanta Kumar Pal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Akt Activation Emulates Chk1 Inhibition and Bcl2 Overexpression and Abrogates G2 Cell Cycle Checkpoint by Inhibiting BRCA1 Foci

(2010) Ivana Tonic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Protein S3, a New Substrate of Akt, Serves as a Signal Mediator between Neuronal Apoptosis and DNA Repair

(2010) Sang Bae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2

(2010) Naihan Xu et al.   JOURNAL OF CELL BIOLOGY

Down-Regulation of Rad51 Expression Overcomes Drug Resistance to Gemcitabine in Human Non-Small-Cell Lung Cancer Cells

(2010) M.-S. Tsai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation

(2010) R Deng et al.   ONCOGENE

Nuclear Phospho-Akt Increase Predicts Synergy of PI3K Inhibition and Doxorubicin in Breast and Ovarian Cancer

(2010) J. J. Wallin et al.   Science Translational Medicine

The PKB/AKT Pathway in Cancer

(2009) Amancio Carnero   CURRENT PHARMACEUTICAL DESIGN

Behind the wheel and under the hood: Functions of cyclin-dependent kinases in response to DNA damage

(2009) Lara Wohlbold et al.   DNA REPAIR

Estrogen Inhibits ATR Signaling to Cell Cycle Checkpoints and DNA Repair

(2009) Ali Pedram et al.   MOLECULAR BIOLOGY OF THE CELL

Roles of MKK1/2-ERK1/2 and Phosphoinositide 3-Kinase-AKT Signaling Pathways in Erlotinib-Induced Rad51 Suppression and Cytotoxicity in Human Non-Small Cell Lung Cancer Cells

(2009) J.-C. Ko et al.   MOLECULAR CANCER RESEARCH

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy in hamster ovary cells

(2009) I Plo et al.   ONCOGENE

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling

(2009) Mahmoud Toulany et al.   RADIOTHERAPY AND ONCOLOGY

PIKK-ing a New Partner: A New Role for PKB in the DNA Damage Response

(2008) Susan P. Lees-Miller   CANCER CELL

Negative Regulation of AKT Activation by BRCA1

(2008) T. Xiang et al.   CANCER RESEARCH

AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

(2008) I. Plo et al.   CANCER RESEARCH

ATR signaling can drive cells into senescence in the absence of DNA breaks

(2008) L. I. Toledo et al.   GENES & DEVELOPMENT

Phosphorylation of MDMX Mediated by Akt Leads to Stabilization and Induces 14-3-3 Binding

(2008) Vanessa Lopez-Pajares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

(2008) S. Maddika et al.   JOURNAL OF CELL SCIENCE

Unscheduled Akt-Triggered Activation of Cyclin-Dependent Kinase 2 as a Key Effector Mechanism of Apoptin's Anticancer Toxicity

(2008) S. Maddika et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

(2008) M. Toulany et al.   MOLECULAR CANCER THERAPEUTICS

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition

(2008) S. Caporali et al.   MOLECULAR PHARMACOLOGY

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

(2008) J Liu et al.   ONCOGENE

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt signaling: a damaging interaction makes good

(2008) Alex Toker   TRENDS IN BIOCHEMICAL SCIENCES

PHLiPPing the switch on Akt and protein kinase C signaling

(2008) John Brognard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM