Recent Advances in the Chemistry and Biology of Benzothiazoles

Benzothiazoles exhibit broad-spectrum antitumor activity: Their potency, structure–activity and structure–metabolism relationships

(2014) Xilei Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organocatalytic Syntheses of Benzoxazoles and Benzothiazoles using Aryl Iodide and Oxone via C–H Functionalization and C–O/S Bond Formation

(2014) Santhosh Kumar Alla et al.   JOURNAL OF ORGANIC CHEMISTRY

Room-Temperature Ligand-Free Pd/C-Catalyzed C–S Bond Formation: Synthesis of 2-Substituted Benzothiazoles

(2014) Yannan Cheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Molecular Iodine Promoted Divergent Synthesis of Benzimidazoles, Benzothiazoles, and 2-Benzyl-3-phenyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazines

(2014) Gunaganti Naresh et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating a benzothiazole ring system

(2013) Mohammed Afzal Azam et al.   ACTA PHARMACEUTICA

Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents

(2013) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells

(2013) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New anticancer active and selective phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding

(2013) Livio Racané et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimosquito properties of 2,6-substituted benzo[d]thiazole and 2,4-substituted benzo[d]thiazole analogues against Anopheles arabiensis

(2013) Katharigatta Narayanaswamy Venugopala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, physicochemical characterization, cytotoxicity, antimicrobial, anti-inflammatory and psychotropic activity of new N-[1,3-(benzo)thiazol-2-yl]-ω-[3,4-dihydroisoquinolin-2(1H)-yl]alkanamides

(2013) Alla Zablotskaya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: A hybrid pharmacophore approach

(2013) Sachin Malik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents

(2013) Jin Cai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antimicrobial activity of novel benzothiazole analogs

(2013) Manavendra K. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy

(2013) Sérgio M. Marques et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives

(2013) Ella Meltzer-Mats et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, spectroscopic, cytotoxic aspects and computational study of N-(pyridine-2-ylmethylene)benzo[d]thiazol-2-amine Schiff base and some of its transition metal complexes

(2013) Dina M. Abd El-Aziz et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, cytotoxic evaluation, and in silico studies of substituted N-alkylbromo-benzothiazoles

(2013) Rupinder Kaur Gill et al.   MEDICINAL CHEMISTRY RESEARCH

Cadmium complexes and cocrystals of indium complexes of benzothiazole derivatives and anticancer activities of the cadmium complexes

(2013) Tapan Karmakar et al.   POLYHEDRON

Weinreb amide as an efficient reagent in the one pot synthesis of benzimidazoles and benzothiazoles

(2013) Yadaganahalli K. Bommegowda et al.   TETRAHEDRON LETTERS

Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents

(2012) Ravindra M. Kumbhare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation

(2012) Dennis S.B. Ongarora et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of N-(substituted benzothiazol-2-yl)amides as anticonvulsant and neuroprotective

(2012) Mohd. Zaheen Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinazolino–benzothiazoles: Fused pharmacophores as anticonvulsant agents

(2012) Vinod G. Ugale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents

(2012) Rahul V. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: Their anti-inflammatory and anti-nociceptive activities

(2012) Syed Shafi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzothiazoles: Search for anticancer agents

(2012) Malleshappa N. Noolvi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of antimicrobial activity of 4H-pyrimido[2,1-b]benzothiazole, pyrazole and benzylidene derivatives of curcumin

(2012) Pramod K. Sahu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one

(2012) Vijay S. Patil et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A broad study of two new promising antimycobacterial drugs: Ag(I) and Au(I) complexes with 2-(2-thienyl)benzothiazole

(2012) Guilherme Alves Pereira et al.   POLYHEDRON

Synthesis of novel inhibitors of β-glucuronidase based on benzothiazole skeleton and study of their binding affinity by molecular docking

(2011) Khalid Mohammed Khan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents

(2011) Ravindra M. Kumbhare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel 2-(2-(4-aryloxybenzylidene) hydrazinyl)benzothiazole derivatives as anti-tubercular agents

(2011) Vikas N. Telvekar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs

(2011) Taleb H. Al-Tel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Transition metal-free procedure for the synthesis of S-aryl dithiocarbamates using aryl diazonium fluoroborate in water at room temperature

(2011) Tanmay Chatterjee et al.   GREEN CHEMISTRY

Synthesis, structures and the biological activity study on the metal complexes of 2-(4-aminophenyl)benzothiazole derivative

(2011) Guo-Wu Lin et al.   INORGANICA CHIMICA ACTA

Synthesis and Biological Evaluation of Analogues of AKT (Protein Kinase B) Inhibitor-IV

(2011) Qi Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2-Mercaptobenzothiazoles via DBU-Promoted Tandem Reaction ofo-Haloanilines and Carbon Disulfide

(2011) Fei Wang et al.   ORGANIC LETTERS

One-pot tandem approach for the synthesis of benzimidazoles and benzothiazoles from alcohols

(2011) Goravanahalli M. Raghavendra et al.   TETRAHEDRON LETTERS

Synthesis of novel dipodal-benzimidazole, benzoxazole and benzothiazole from cyanuric chloride: Structural, photophysical and antimicrobial studies

(2011) Vikas S. Padalkar et al.   Journal of Saudi Chemical Society

Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole–pyrrolo[2,1-c][1,4]benzodiazepine conjugates

(2010) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity

(2010) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents

(2010) Balram Soni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety

(2010) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metal-Free Synthesis of 2-Substituted (N, O, C) Benzothiazoles via an Intramolecular C−S Bond Formation

(2010) Enguang Feng et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Synthesis, anticancer activity and docking of some substituted benzothiazoles as tyrosine kinase inhibitors

(2010) Hemal A. Bhuva et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

Catalytic CC, CN, and CO Ullmann-Type Coupling Reactions

(2009) Florian Monnier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A simple and efficient synthesis of 2-substituted benzothiazoles catalyzed by H2O2/HCl

(2009) Hong Yun Guo et al.   CHINESE CHEMICAL LETTERS

Synthesis, characterization and biological evaluation of some thiourea derivatives bearing benzothiazole moiety as potential antimicrobial and anticancer agents

(2009) Sohail Saeed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole

(2009) Nikhil D. Amnerkar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents

(2009) Nilgün Karalı et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel Series of Quinolone and Naphthyridine Derivatives as Potential Topoisomerase I Inhibitors by Scaffold Modification

(2009) Qi-Dong You et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intra- and Intermolecular C−S Bond Formation Using a Single Catalytic System: First Direct Access to Arylthiobenzothiazoles

(2009) Siva Murru et al.   ORGANIC LETTERS

Heterocycle Formation via Palladium-Catalyzed Intramolecular Oxidative C−H Bond Functionalization: An Efficient Strategy for the Synthesis of 2-Aminobenzothiazoles

(2009) Laurie L. Joyce et al.   ORGANIC LETTERS

A Simple, Microwave-Assisted, and Solvent-Free Synthesis of 2-Arylbenzothiazoles by Acetic Acid–Promoted Condensation of Aldehydes with 2-Aminothiophenol in Air

(2009) Davood Azarifar et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Simple and Efficient One-Pot Synthesis of 2-Substituted Benzoxazole and Benzothiazole

(2009) Sachin S. Patil et al.   SYNTHETIC COMMUNICATIONS

Bakers’ yeast catalyzed synthesis of benzothiazoles in an organic medium

(2009) Umesh R. Pratap et al.   TETRAHEDRON LETTERS

Photochemical cyclization of thioformanilides by chloranil: An approach to 2-substituted benzothiazoles

(2009) Valentina Rey et al.   TETRAHEDRON LETTERS

Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis

(2008) Gwilherm Evano et al.   CHEMICAL REVIEWS

Riluzole in the Treatment of Mood and Anxiety Disorders

(2008) Christopher Pittenger et al.   CNS DRUGS

Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents

(2008) S.N. Manjula et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mild and Highly Efficient Method for the Synthesis of 2-Arylbenzimidazoles and 2-Arylbenzothiazoles

(2008) Kiumars Bahrami et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient C–S cross coupling catalyzed by Cu2O

(2008) Hua-Jian Xu et al.   TETRAHEDRON LETTERS