☆ 4.7 Article

Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Journal

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Volume 45, Issue 3, Pages 1068-1077

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

DOI: 10.1016/j.ejmech.2009.12.001

Keywords

3-Spiroindolinone; Benzothiazole; Synthesis; X-ray analyses; Antioxidant activity; Cytotoxicity

Categories

Chemistry, Medicinal

Funding

Istanbul University Research Fund [BYP-1895]

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Abstract

3H-Spiro[1,3-benzothiazole-2,3'-indol]-2'(1',H)-ones 3a-c and 4a-e were synthesized from treating the 5-substituted 1H-indole-2,3-diones with 2-aminothiophenol in ethanol. The structures were confirmed by elemental analyses, spectrometry (IR, H-1 NMR, C-13 NMR, HSQC-2D and LCMS-APCI) and single crystal X-ray analysis. The new compounds were screened for their antioxidant activities such as the Fe3+/ ascorbate system induced inhibition of lipid peroxidation (LP) in liposomes, trolox equivalent antioxidant capacity (TEAC), scavenging effect on diphenylpicryl hydrazine (DPPH center dot), and reducing power. These compounds showed potent scavenging activities against DPPH center dot and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS(center dot+)) radicals, reducing powers, and strong inhibitory capacity on lipid peroxidation. Compound 4a incorporating methyl both at R-1 and R-2 was found to be the most potent antioxidant described in this study. Compounds 3b and 4b were selected as representative compounds by the National Cancer Institute for screening against anticancer activity and these compounds were found to be cytotoxic against CNS cancer cell line SNB-75 in the primary Screen. (C) 2009 Elsevier Masson SAS. All rights reserved.

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