Journal
TETRAHEDRON LETTERS
Volume 54, Issue 21, Pages 2693-2695Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.03.075
Keywords
Weinreb amide; Benzimidazoles; Benzothiazoles; Boron trifluoride etherate; o-Diaminoarene; o-Aminothiophenol
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Funding
- UGC, Govt. of India [37-456/2009[SR], UOM/IOE/RESEARCH/1/2010-11]
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One pot synthesis of 2-substituted benzimidazoles/benzothiazoles through condensation is followed by cyclization of Weinreb amide with o-diaminoarene or o-aminothiophenol is reported. In the presence of boron trifluoride etherate in 1,4-dioxane solvent, a high yield (75-94%) was achieved within 60 min. Weinreb amide shows high selectivity in the reaction, even in presence of other active functional groups such as carboxyl, halogen, cyano, and methoxy. (c) 2013 Elsevier Ltd. All rights reserved.
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