Article
Multidisciplinary Sciences
Tetsundo Furuya, Daisuke Nakane, Kenichi Kitanishi, Natsuki Katsuumi, Arshak Tsaturyan, Igor N. Shcherbakov, Masaki Unno, Takashiro Akitsu
Summary: A novel hybrid protein, CuST@lysozyme, composed of a superoxide dismutase-active Cu(II) complex (CuST) and lysozyme, was prepared. Spectroscopic and electrochemical analyses confirmed the binding of CuST to lysozyme. The crystal structure of CuST@lysozyme revealed the binding of the His15 imidazole group of lysozyme to the Cu(II) center of CuST. The combination of CuST with lysozyme did not decrease the superoxide dismutase activity of CuST. Based on various studies, a proposed O-2(-) disproportionation mechanism catalyzed by CuST@lysozyme was discussed.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Shazia Parveen, Farukh Arjmand, Qianfan Zhang, Musheer Ahmad, Arif Khan, Loic Toupet
Summary: In this study, the synthesis and single crystal X-ray structure of Cu(II)-picolinic acid complex, 1 as a potent topoisomerase I inhibitor was reported. Biochemical studies revealed the complex's higher binding propensity towards tRNA, significant inhibitory effect on enzyme catalytic activity, and strong antimicrobial potential. Additionally, DFT and molecular docking studies provided insights into electronic transitions and specific binding preferences at the target site.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Applied
Mona A. Alamri, Mutlaq. Al-Jahdali, Najlaa S. Al-Radadi, Mostafa A. Hussien
Summary: This study synthesized a series of metal complexes of triazene ligands and characterized them using various analytical methods. The cytotoxic and DNA binding activities of the complexes were studied, revealing that the Zn(II) complex exhibited the highest activity. Molecular docking results correlated well with the cytotoxicity experiments.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sivaswamy Kanchanadevi, Frank R. Fronczek, Charles Immanuel David, Raju Nandhakumar, Viswanathan Mahalingam
Summary: Two mononuclear complexes of Co(II) and Ni(II) and a binuclear copper(II) complex were synthesized and characterized for their biological activities, including DNA and protein-binding, antioxidant and anticancer activity. The interaction with DNA and protein, as well as radical scavenging ability, of the complexes were studied, and their cytotoxicity towards human cancer cell lines was tested.
INORGANICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
A. Sakthivel, B. Thangagiri, N. Raman, J. Joseph, Ramu Guda, Mamatha Kasula, L. Mitu
Summary: Novel macrocyclic Schiff base complexes with different metal ions have been synthesized and characterized, showing promising antioxidant, antimicrobial, and anticancer activities. The interaction of the complexes with DNA through the macrocyclic ligand and the inhibitory effects on target proteins such as EGFR and HER2 have been investigated and demonstrated.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Multidisciplinary
Joanna Czescik, Susanna Zamolo, Tamis Darbre, Riccardo Rigo, Claudia Sissi, Adam Pecina, Laura Riccardi, Marco De Vivo, Fabrizio Mancin, Paolo Scrimin
Summary: Gold nanoparticles can efficiently catalyze chemical reactions as nanozymes, exhibiting the highest efficiency in cleaving plasmid DNA. By successfully mimicking the suggested structure of natural metallonucleases, this study provides important insights into the catalytic mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Mouayed A. Hussein, Adyan A. Yaseen
Summary: A novel copper complex was synthesized and characterized, and its interaction with DNA and antitumor capacity against human colorectal cancer cells were investigated.
TRANSITION METAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ding Pei-Pei, Li Ming, Wu Yu, Yan Jun-Tao, Wang Chun-Lei, Wang Yang, Mao Jia-Wei
Summary: A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn(II)-Ni(II) complex has been synthesized and characterized. The structure and interaction of the complex with CT-DNA has been investigated.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Sabeel M. Basheer, Puthiyavalappil Rasin, Saravana Loganathan Ashok Kumar, Moorthy Saravana Kumar, Anandaram Sreekanth
Summary: 2-acetylpyrzine N-(4)-cyclohexylthiosemicarbazide (H2L) and its Ni(II) and Fe(III) metal complexes were synthesized and studied for their interactions with Bovine Serum Albumin and CT-DNA. The complexes exhibited high affinity for DNA and showed non-covalent intercalation.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Kumudini Paliwal, Paramita Haldar, P. K. Sudhadevi Antharjanam, Manjuri Kumar
Summary: This study characterized the isolated copper(II) complex [CuL(o-phen)]center dot H2O (1) using single-crystal X-ray crystallography. The results showed that 1 has a strong binding affinity with calf thymus DNA and human serum albumin (HSA), and exhibits potential anticancer activity by promoting DNA damage.
Article
Multidisciplinary Sciences
Kazuki Kato, Sae Okazaki, Soumya Kannan, Han Altae-Tran, F. Esra Demircioglu, Yukari Isayama, Junichiro Ishikawa, Masahiro Fukuda, Rhiannon K. Macrae, Tomohiro Nishizawa, Kira S. Makarova, Eugene Koonin, Feng Zhang, Hiroshi Nishimasu
Summary: This study reports the structure of the IscB protein in complex with its cognate omega RNA and a target DNA from the human gut. The structure reveals the detailed architecture of the IscB-omega RNA ribonucleoprotein complex and shows how IscB assembles with the omega RNA to mediate RNA-guided DNA cleavage. The large omega RNA scaffold compensates for the lack of the recognition lobe in Cas9 and participates in the recognition of the guide RNA-target DNA heteroduplex.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Ola A. El-Gammal, Farid Sh Mohamed, Ghada N. Rezk, Ashraf A. El-Bindary
Summary: The synthesis, characterization, and bioactivities of a new Schiff base ligand and its metal complexes, including coordination mode, DNA binding behavior, antimicrobial activity, antioxidant activity, and anticancer activity, were investigated in this study.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Aveli Rambabu, Sreenu Daravath, Dasari Shiva Shankar, Shivaraj
Summary: The two mononuclear metal complexes bind to DNA through an intercalation mode and exhibit good cleavage ability under oxidative and photolytic conditions. Both complexes show marked biocidal potential in vitro.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Kalai Selvan Karumban, Rajnikant Raut, Parth Gupta, Arabinda Muley, Bishnubasu Giri, Sadananda Kumbhakar, Ashish Misra, Somnath Maji
Summary: Mononuclear cobalt(II) complexes were synthesized and characterized, showing strong DNA binding ability and efficient DNA cleavage. These complexes also induced apoptosis in human cancer cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
A. Vijayaraj, R. Prabu, R. Suresh, R. Sangeetha Kumari, V. Kaviyarasan, V. Narayanan, P. Tamizhdurai, V. L. Mangesh, Fatmah Ali Alasmary, Umamaheswari Rajaji, Mani Govindasamy
Summary: This study reports the characterization of several d-f heterobinuclear [GdCuL1-5(bpy)2(NO3)2] complexes based on 2,2'-bipyridyl ligands using spectroscopy and elemental analysis. The complexes were investigated for their luminescence, genetic code properties, catalytic activity, magnetism, and breaking attributes. The [GdCuL1-5(bpy)2(NO3)2] complexes exhibited two one-electron irreversible reduction events and showed ferromagnetic coupling. The inceptive rate of progress for oxidizing 1,2-benzenediol to cyclohexa-3,5-diene-1,2-dione was higher for longer chain complexes. The [GdCuL5(bpy)2(NO3)2] and [GdCuL4(bpy)2(NO3)2] complexes showed strong DNA genetic code properties, and the complexes exhibited singlet oxygen-mediated oxidative rift of circular recombinant plasmid pBR322 cloning vector in the presence of 2-sulfanylethanol.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)