Novel therapeutic targets for the treatment of heart failure

Omecamtiv mecarbil cardiac myosin activator treatment of heart failure

(2015) J. Tamargo et al.   DRUGS OF THE FUTURE

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

(2011) Scott D. Solomon et al.   EUROPEAN HEART JOURNAL

Diuretic Strategies in Patients with Acute Decompensated Heart Failure

(2011) G. Michael Felker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical development of pharmacologic agents for acute heart failure syndromes: A proposal for a mechanistic translational phase

(2010) Mihai Gheorghiade et al.   AMERICAN HEART JOURNAL

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Impact of Worsening Renal Function During Hospital Admission on Resource Utilization in Patients With Heart Failure

(2010) Peter M. Herout et al.   AMERICAN JOURNAL OF CARDIOLOGY

Urocortins in heart failure

(2010) Sowmya Venkatasubramanian et al.   BIOCHEMICAL PHARMACOLOGY

Ryanodine receptor calcium channels and their partners as drug targets

(2010) John J. Mackrill   BIOCHEMICAL PHARMACOLOGY

A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1–calcineurin pathway

(2010) Ana Kilić et al.   CARDIOVASCULAR RESEARCH

Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure

(2010) W. Poller et al.   CARDIOVASCULAR RESEARCH

Ca 2+ Cycling and New Therapeutic Approaches for Heart Failure

(2010) Anne-Marie Lompré et al.   CIRCULATION

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

(2010) Gad A. Silberman et al.   CIRCULATION

Cardiorenal Syndrome

(2010) Jeremy S. Bock et al.   CIRCULATION

Role of Inotropic Agents in the Treatment of Heart Failure

(2010) Joshua I. Goldhaber et al.   CIRCULATION

Acute Cardiovascular Effects of Apelin in Humans

(2010) A.G. Japp et al.   CIRCULATION

The Future of Pharmacological Therapy for Heart Failure

(2010) Yusuke Sata et al.   CIRCULATION JOURNAL

Inhibition of Elevated Ca 2+ /Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium

(2010) Samuel Sossalla et al.   CIRCULATION RESEARCH

DPP-4 Inhibition by Sitagliptin Improves the Myocardial Response to Dobutamine Stress and Mitigates Stunning in a Pilot Study of Patients With Coronary Artery Disease

(2010) Philip A. Read et al.   Circulation-Cardiovascular Imaging

A Global Rank End Point for Clinical Trials in Acute Heart Failure

(2010) G. Michael Felker et al.   Circulation-Heart Failure

Clinical Trials of Pharmacological Therapies in Acute Heart Failure Syndromes

(2010) G. Michael Felker et al.   Circulation-Heart Failure

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Treatment of Type 2 Diabetes and Outcomes in Patients With Heart Failure: A Nested Case-Control Study From the U.K. General Practice Research Database

(2010) M. R. MacDonald et al.   DIABETES CARE

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

(2010) B. A. Borlaug et al.   EUROPEAN HEART JOURNAL

Clinical trials update from the European Society of Cardiology Heart Failure Meeting 2010: TRIDENT 1, BENEFICIAL, CUPID, RFA-HF, MUSIC, DUEL, handheld BNP, phrenic nerve stimulation, CHAMPION and CABG with CRT study

(2010) John G.F. Cleland et al.   EUROPEAN JOURNAL OF HEART FAILURE

Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial

(2010) Suzan Willemsen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

A Phase II, Randomized, Double-Blind, Multicenter, Based on Standard Therapy, Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure

(2010) Runlin Gao et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

(2010) Luis Miguel Ruilope et al.   LANCET

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

(2010) Karl Swedberg et al.   LANCET

Rolofylline, an Adenosine A1−Receptor Antagonist, in Acute Heart Failure

(2010) Barry M. Massie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: Results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-HF) trial

(2009) Sanjiv J. Shah et al.   AMERICAN HEART JOURNAL

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

(2009) Karl Toischer et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion

(2009) John R. Ussher et al.   BASIC RESEARCH IN CARDIOLOGY

Adenosine1 Receptor Antagonism

(2009) Rena H. Shah et al.   Cardiology in Review

Protein kinase C in heart failure: a therapeutic target?

(2009) S. S. Palaniyandi et al.   CARDIOVASCULAR RESEARCH

Cinaciguat (BAY 58–2667) Improves Cardiopulmonary Hemodynamics in Patients With Acute Decompensated Heart Failure

(2009) Harald Lapp et al.   CIRCULATION

Heart Disease and Stroke Statistics—2010 Update

(2009) et al.   CIRCULATION

Effects of Long-Term Intravenous Administration of Adrenomedullin (AM) Plus hANP Therapy in Acute Decompensated Heart Failure

(2009) Toshio Nishikimi et al.   CIRCULATION JOURNAL

Heart Failure as a Multiple Hormonal Deficiency Syndrome

(2009) Luigi Saccà   Circulation-Heart Failure

Loop Diuretics in Acute Decompensated Heart Failure

(2009) G. Michael Felker et al.   Circulation-Heart Failure

Effect of the long-term administration of nebivolol on clinical symptoms, exercise capacity and left ventricular function in patients with heart failure and preserved left ventricular ejection fraction: background, aims and design of the ELANDD study

(2009) Otto Kamp et al.   Clinical Research in Cardiology

New Investigational Drugs for the Management of Acute Heart Failure Syndromes

(2009) J. Tamargo et al.   CURRENT MEDICINAL CHEMISTRY

Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression

(2009) N. Couvreur et al.   EUROPEAN HEART JOURNAL

Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial

(2009) John J.V. McMurray et al.   EUROPEAN JOURNAL OF HEART FAILURE

A meta-analysis of erythropoiesis-stimulating agents in anaemic patients with chronic heart failure

(2009) Bo Jin et al.   EUROPEAN JOURNAL OF HEART FAILURE

Erythropoietin treatment in patients with chronic heart failure: a meta-analysis

(2009) P van der Meer et al.   HEART

Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond

(2009) John R. Teerlink et al.   HEART FAILURE REVIEWS

A novel approach to improve cardiac performance: cardiac myosin activators

(2009) John R. Teerlink   HEART FAILURE REVIEWS

Role of guanylate cyclase modulators in decompensated heart failure

(2009) Veselin Mitrovic et al.   HEART FAILURE REVIEWS

Reconsidering the Roles of the Mineralocorticoid Receptor

(2009) John W. Funder   HYPERTENSION

Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage

(2009) Heiko Funke-Kaiser et al.   HYPERTENSION RESEARCH

The Immune System and Chronic Heart Failure

(2009) James E. Fildes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Acute Heart Failure Syndromes

(2009) Mihai Gheorghiade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Failure With Preserved Ejection Fraction Is Characterized by Dynamic Impairment of Active Relaxation and Contraction of the Left Ventricle on Exercise and Associated With Myocardial Energy Deficiency

(2009) Thanh T. Phan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

End Points for Clinical Trials in Acute Heart Failure Syndromes

(2009) Larry A. Allen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

(2009) Sharon Ann Hunt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Micronutrient Deficiencies

(2009) Victor Soukoulis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Diseases

(2009) Carl J. Lavie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential

(2009) Thomas Unger et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial

(2009) Marvin A Konstam et al.   LANCET

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

(2009) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Ryanodine receptor-mediated arrhythmias and sudden cardiac death

(2009) Lynda M. Blayney et al.   PHARMACOLOGY & THERAPEUTICS

Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure

(2008) Sharad Rastogi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Potential novel pharmacological therapies for myocardial remodelling

(2008) U. Landmesser et al.   CARDIOVASCULAR RESEARCH

Arginine Vasopressin Antagonists for the Treatment of Heart Failure and Hyponatremia

(2008) John J. Finley et al.   CIRCULATION

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

(2008) Ignatios Ikonomidis et al.   CIRCULATION

New Drugs for the Treatment of Diabetes

(2008) Silvio E. Inzucchi et al.   CIRCULATION

Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways

(2008) Kiwon Ban et al.   CIRCULATION

Ca 2+ /Calmodulin-Dependent Protein Kinase IIδ and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure

(2008) Julie Bossuyt et al.   CIRCULATION RESEARCH

Clinical Use of Phosphodiesterase-5 Inhibitors in Chronic Heart Failure

(2008) Marco Guazzi   Circulation-Heart Failure

Effects of the Oral Direct Renin Inhibitor Aliskiren in Patients With Symptomatic Heart Failure

(2008) John J.V. McMurray et al.   Circulation-Heart Failure

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

(2008) P. Mulder et al.   EUROPEAN HEART JOURNAL

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008‡

(2008) Kenneth Dickstein et al.   EUROPEAN JOURNAL OF HEART FAILURE

Adenosine and kidney function: Potential implications in patients with heart failure

(2008) Volker Vallon et al.   EUROPEAN JOURNAL OF HEART FAILURE

Recent advances in the discovery of non-peptidic direct renin inhibitors as antihypertensives: new patent applications in years 2000 – 2008

(2008) Fumiaki Yokokawa et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Vasodilators in the treatment of acute heart failure: what we know, what we don’t

(2008) Marco Metra et al.   HEART FAILURE REVIEWS

Venous Thromboembolism and Mortality Associated With Recombinant Erythropoietin and Darbepoetin Administration for the Treatment of Cancer-Associated Anemia

(2008) Charles L. Bennett   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The PROTECT Pilot Study: A Randomized, Placebo-Controlled, Dose-Finding Study of the Adenosine A1 Receptor Antagonist Rolofylline in Patients With Acute Heart Failure and Renal Impairment

(2008) Gad Cotter et al.   JOURNAL OF CARDIAC FAILURE

The Potential Role of Erythropoietin in Chronic Heart Failure: From the Correction of Anemia to Improved Perfusion and Reduced Apoptosis?

(2008) Stefan A.J. Timmer et al.   JOURNAL OF CARDIAC FAILURE

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Heart Failure and Low-T3Syndrome: A Randomized, Placebo-Controlled Study

(2008) Alessandro Pingitore et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling

(2008) P. Wohlfart et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anemia and Chronic Heart Failure

(2008) Inder S. Anand   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Vascular Effects of Apelin In Vivo in Man

(2008) Alan G. Japp et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Insulin-Resistant Cardiomyopathy

(2008) Ronald M. Witteles et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Failure-Related Hospitalization in the U.S., 1979 to 2004

(2008) Jing Fang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Oxypurinol in Patients With Symptomatic Heart Failure

(2008) Joshua M. Hare et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent

(2008) Mihai Gheorghiade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Intravenous Iron Sucrose on Exercise Tolerance in Anemic and Nonanemic Patients With Symptomatic Chronic Heart Failure and Iron Deficiency

(2008) Darlington O. Okonko et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET

Aliskiren: the first renin inhibitor for clinical treatment

(2008) Chris Jensen et al.   NATURE REVIEWS DRUG DISCOVERY

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS

Toward Biologically Targeted Therapy of Calcium Cycling Defects in Heart Failure

(2008) Yasuhiro Ikeda et al.   PHYSIOLOGY

Diastolic heart failure: mechanisms and controversies

(2008) Maral Ouzounian et al.   Nature clinical practice. Cardiovascular medicine

Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction

(2007) Leo Timmers et al.   CIRCULATION RESEARCH