Article
Nutrition & Dietetics
Ashley Jazzar, Danielle Jacques, Ghassan Bkaily
Summary: Insulin-induced cardiac hypertrophy is associated with changes in Na+ and Ca2+ homeostasis, with taurine pre-treatment preventing these effects. Additionally, chronic taurine treatment prevents insulin-induced morphological and ionic remodeling of cardiomyocytes.
Article
Cell Biology
Yizeng Li, Xiaohan Zhou, Sean X. Sun
Summary: Cells without a stiff cell wall, such as mammalian cells, must actively regulate their volume, with water flow determining cell volume variation. Proton and bicarbonate play significant roles in cell volume regulation, and cells need redundant mechanisms to maintain homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Al-Anood Al-Shamasi, Rozina Elkaffash, Meram Mohamed, Menatallah Rayan, Dhabya Al-Khater, Alain-Pierre Gadeau, Rashid Ahmed, Anwarul Hasan, Hussein Eldassouki, Huseyin Cagatay Yalcin, Muhammad Abdul-Ghani, Fatima Mraiche
Summary: Abnormality in glucose homeostasis due to hyperglycemia or insulin resistance is the hallmark of type 2 diabetes mellitus, leading to cellular dysfunction and diabetic cardiomyopathy. New antihyperglycemic agents such as GLP-1 agonists and SGLT2 inhibitors have shown cardioprotective effects by attenuating endothelial dysfunction and improving cardiovascular safety. The mechanism behind these effects is not fully understood, but there is evidence suggesting an interaction between NHE and SGLT2i in cardiovascular homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Danfeng Jiang, Minami Matsuzaki, Takanori Ida, Kazuo Kitamura, Toshihiro Tsuruda, Koichi Kaikita, Johji Kato
Summary: Excessive activation of the sympathetic nervous system is involved in cardiovascular damage including cardiac hypertrophy. Natriuretic peptides are assumed to exert protective actions for the heart, alleviating hypertrophy and/or fibrosis of the myocardium. However, our study shows that both atrial and C-type natriuretic peptides (ANP and CNP) potentiate cardiac hypertrophic response to noradrenaline (NA) in rats, suggesting a possible pro-hypertrophic action of natriuretic peptides on the heart.
Article
Medicine, Research & Experimental
Yong Xie, Qian Li, Hai-Feng Zhang, Tu-Cheng Huang, Ying Yang, Yong-Qing Lin, Jing-Ting Mai, Zhu-Zhi Wen, Wo-Liang Yuan, Jing-Feng Wang, Yang-Xin Chen
Summary: The study found that CRP can upregulate NCX1 expression and increase intracellular calcium concentration in cardiomyocytes via the NF-κB pathway, suggesting it may play a role in cardiac arrhythmia by directly influencing calcium homeostasis in cardiomyocytes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Peripheral Vascular Disease
Carlos M. Ferrario, Seethalakshmi R. Iyer, John C. Burnett, Sarfaraz Ahmad, Kendra N. Wright, Jessica L. VonCannon, Amit Saha, Leanne Groban
Summary: The study identified the presence of Ang (1-12) in the blood of both normotensive subjects and patients with hypertension, regardless of age or sex, suggesting its role as a potential source for Ang II production in the blood. Higher plasma Ang (1-12) concentrations in hypertensive patients were correlated with certain indicators.
Article
Food Science & Technology
Rui Ge, Yuanhui Mao, Yuxin Zhao, Yanna Fan, Yannan Zhang, Xiujuan Tao, Jianjun Yang
Summary: In this study, it was found that ACEIP derived from Lycium barbarum L. could improve cardiac hypertrophy and diastolic dysfunction in a HFpEF mouse model. These effects were mediated through the activation of the ACE2/Ang (1-7)/MasR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Feng
Summary: This study investigated the effect of NHE-1 on hippocampal cell apoptosis and seizures in a lithium chloride-pilocarpine epileptic rat model. The expression of NHE-1, calpain1, and apoptosis in the hippocampus were increased in the model group, while down-regulating NHE-1 decreased calpain1 expression and alleviated hippocampal cell apoptosis. Additionally, down-regulation of NHE-1 reduced the frequency and duration of seizures. Therefore, hippocampal NHE-1 overexpression is closely related to the development of neuronal apoptosis in a rat model of epilepsy, and downregulating NHE-1 expression can reduce cell apoptosis. The NHE-1/calpain1 signaling pathway may be an important mechanism leading to hippocampal cell apoptosis.
Article
Physiology
Johny Al-Khoury, Danielle Jacques, Ghassan Bkaily
Summary: It is well accepted that hypertension may lead to heart failure, but little is known about how hypotension could contribute to hereditary cardiomyopathy. This study used an animal model to show that a decrease in blood pressure is associated with the development of HCM, and it could be a potential biomarker for predicting HF and early death. Blocking NHE1 significantly prevented the reduction in blood pressure, suggesting other mechanisms could also play a role in hypotension in HCM.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Milton Packer
Summary: Patients with heart failure often experience fluid retention due to sodium retention by the kidneys, which can be relieved by conventional diuretics. However, it has been suggested that sodium-glucose cotransporter 2 (SGLT2) inhibitors could selectively alleviate fluid overload in these patients by modulating the volume set point. A review of 15 randomized controlled trials found that SGLT2 inhibitors did increase urine volume in the short term, but there was no sustained diuretic effect. There was also no evidence of objective decongestion or reduction in circulating natriuretic peptides observed in these trials.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Microbiology
Yiling Zhang, Shujuan Zhang, Zhiwei Sun, Xiangyang Liu, Guisong Liao, Zheng Niu, Zifei Kan, Shasha Xu, Jingyi Zhang, Hong Zou, Xingcui Zhang, Zhenhui Song
Summary: Porcine Epidemic Diarrhea Virus (PEDV) is a significant cause of diarrhea and death in piglets. This study found that PEDV induces diarrhea in piglets by inhibiting Na+ absorption in pig intestinal epithelial cells. The study also demonstrated the importance of EGFR in regulating NHE3 activity after PEDV infection.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ewelina Jozefczuk, Piotr Szczepaniak, Tomasz Jan Guzik, Mateusz Siedlinski
Summary: The silencing of Sphk1 in neonatal mouse CMs was shown to enhance their postnatal maturation in both physiological and stress conditions, as evidenced by accelerated cell maturation, inhibition of proliferation, and induction of developmental pathways. This effect was further supported by the upregulation of the Akt signaling pathway and downregulation of Gsk3β, indicating physiological hypertrophy in the absence of Sphk1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Alexander Spasov, Alexander Ozerov, Pavel Vassiliev, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Roman Litvinov, Alexander Borisov, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Georgy Uskov, Nadezhda Ovsyankina
Summary: Novel NHE-1 inhibitors were developed by functionalizing quinazoline derivatives, showing nanomolar activity and a range of pharmacological properties. Some compounds displayed anti-glycation, anti-inflammatory, and intraocular pressure-reducing effects, while others exhibited anti-depressant activity. These compounds hold promise as potential agents against various diseases.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Matthew A. Sparks, Fitra Rianto, Edward Diaz, Ritika Revoori, Thien Hoang, Lucas Bouknight, Johannes Stegbauer, Anuradha Vivekanandan-Giri, Phillip Ruiz, Subramaniam Pennathur, Dennis M. Abraham, Susan B. Gurley, Steven D. Crowley, Thomas M. Coffman
Summary: Deletion of AT(1A) receptors in cardiomyocytes plays a crucial role in regression of cardiac hypertrophy, independent of reducing pressure overload.
Article
Plant Sciences
Georgia I. Nasi, Foteini D. Aktypi, Panagiotis M. Spatharas, Nikolaos N. Louros, Paraskevi L. Tsiolaki, Vassiliki Magafa, Ioannis P. Trougakos, Vassiliki A. Iconomidou
Summary: This study investigates the amyloidogenic properties of a 34-residue-long peptide in Arabidopsis thaliana under different pH conditions, and explores its association with other A. thaliana proteins using bioinformatics tools.
Review
Biochemical Research Methods
Cherine N. Fawaz, Iman S. Makki, Jalal M. Kazan, Nour Y. Gebara, Farah S. Andary, Muheiddine M. Itani, Mohammad El-Sayyed, Asad Zeidan, Angelo Quartarone, Hala Darwish, Stefania Mondello
EXPERT REVIEW OF PROTEOMICS
(2015)
Review
Endocrinology & Metabolism
C. M. Ghantous, Z. Azrak, S. Hanache, W. Abou-Kheir, A. Zeidan
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2015)
Review
Medicine, Research & Experimental
Raffaele Altara, Marco Manca, Rita D. Brandao, Asad Zeidan, George W. Booz, Fouad A. Zouein
Article
Pharmacology & Pharmacy
Moustafa Al Heriri, Kazem Zibara, Wissam Farhat, Yasmine Hashem, Nadia Soudani, Farah Al Ibrahim, Eva Hamade, Asad Zeidan, Ahmad Husari, Firas Kobeissy
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Wared Nour-Eldine, Crystal M. Ghantous, Kazem Zibara, Leila Dib, Hawraa Issaa, Hana A. Itani, Nabil El-Zein, Asad Zeidan
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Physiology
Nadia Soudani, Crystal M. Ghantous, Zein Farhat, Wassim N. Shebaby, Kazem Zibara, Asad Zeidan
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Cell Biology
Kazem Zibara, Asad Zeidan, Hassan Bjeije, Nouhad Kassem, Bassam Badran, Nabil El-Zein
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2017)
Article
Cell Biology
Maya Fakhry, Najwa Skafi, Mohammad Fayyad-Kazan, Firas Kobeissy, Eva Hamade, Saida Mebarek, Aida Habib, Nada Borghol, Asad Zeidan, David Magne, Hussein Fayyad-Kazan, Bassam Badran
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Review
Cell Biology
Sadaf Riaz, Asad Zeidan, Fatima Mraiche
JOURNAL OF CELLULAR PHYSIOLOGY
(2017)
Article
Cell Biology
Firas Kobeissy, Abdullah Shaito, Abdullah Kaplan, Lama Baki, Hassan Hayek, Carole Dagher-Hamalian, Ali Nehme, Rana Ghali, Emna Abidi, Ahmad Husari, Asad Zeidan, Fouad A. Zouein, Kazem Zibara
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Cell Biology
Kazem Zibara, Asad Zeidan, Khalil Mallah, Nouhad Kassem, Ali Awad, Frederic Mazurier, Bassam Badran, Nabil El-Zein
CELLULAR SIGNALLING
(2018)
Article
Oncology
Khaled W. Sadek, Mahmoud Y. Haik, Anas A. Ashour, Tahira Baloch, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Asad Zeidan, Ala-Eddin Al Moustafa
CANCER CELL INTERNATIONAL
(2018)
Review
Biochemistry & Molecular Biology
Hatem Maamoun, Shahenda S. Abdelsalam, Asad Zeidan, Hesham M. Korashy, Abdelali Agouni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Laiche Djouhri, Mohammed Imad Malki, Asad Zeidan, Karim Nagi, Trevor Smith
JOURNAL OF DRUG TARGETING
(2019)
Review
Biochemistry & Molecular Biology
Shahenda S. Abdelsalam, Hesham M. Korashy, Asad Zeidan, Abdelali Agouni