Article
Multidisciplinary Sciences
Jonathan B. Murray, Christy Mikhael, Guanghong Han, Lorraine Perciliano de Faria, Wellington J. Rody, L. Shannon Holliday
Summary: The PRR abundant in extracellular vesicles shed by osteoclasts stimulates the activity of (pro)renin. This discovery reveals a novel mechanism for intercellular regulation by extracellular vesicles, with direct implications for bone biology.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Andrea Lopez-Lopez, Begona Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, Maria Garcia-Garrote, Carmen Diaz-Ruiz, Ana Munoz, Jose L. Labandeira-Garcia
Summary: The dysregulation of tissue RAS plays a role in oxidative and inflammatory responses. This study focused on PRR in microglia during neuroinflammatory responses, finding that (pro)renin induced a pro-inflammatory response in microglia through various mechanisms including upregulation of NADPH-oxidase and Rho-kinase activities, downregulation of autophagy, and upregulation of inflammasome activity. Additionally, microglial PRR activation was linked to deleterious effects on dopaminergic cells, which could be blocked by a Rho-kinase inhibitor.
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Oncology
Xin Ouyang, Chuanming Xu
Summary: Cancer is a major global public health problem that affects hundreds of millions of people worldwide, and currently lacks reliable biomarkers for predicting its clinical outcomes. Recent research has shown that (pro)renin receptor (PRR) acts as a novel biomarker in various types of cancer. This review summarizes the current understanding of PRR in cancer, including its expression levels in different cancers, potential mechanisms in cancer progression, and its role in cancer treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chuanming Xu, Chunju Liu, Jianhua Xiong, Jun Yu
Summary: Cardiovascular diseases are major public health problems globally and the activation of the (Pro)renin receptor (PRR) plays a significant role in cardiovascular homeostasis. PRR activation is associated with myocardial ischemia/reperfusion injury, cardiac hypertrophy, heart failure, vascular smooth muscle cell proliferation, endothelial cell dysfunction, and the progression of vascular diseases. Targeting PRR may have benefits for patients with cardiovascular diseases.
Review
Cell Biology
Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amilcar Falcao, M. Teresa Cruz, Ana Fortuna
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by Tau hyperphosphorylation and A beta deposits. Recent scientific evidence suggests that age-related vascular alterations and cardiovascular risk factors play a role in the development of AD. Drugs targeting the Renin Angiotensin System (RAS) have the potential to delay AD development due to their effects on brain RAS. The ACE 1/Ang II/AT1R axis in AD is believed to have detrimental effects, while the alternative axis ACE 1/Ang II/AT2R; ACE 2/Ang (1 7)/MasR; Ang IV/AT4R (IRAP) seems to have beneficial effects on memory and cognition. Retrospective studies and pre-clinical studies support the therapeutic potential of RAS drugs for AD.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, General & Internal
Aimin Yang, Hongjiang Wu, Eric S. H. Lau, Mai Shi, Baoqi Fan, Alice Pik-Shan Kong, Ronald Ching -Wan Ma, Andrea On-Yan Luk, Juliana Chung-Ngor Chan, Elaine Chow
Summary: The study found that RAS inhibitors are associated with lower cancer risk in type 2 diabetes patients, with better effects for users of ARBs. These results suggest that RASi may have broader benefits for patients with diabetes.
Article
Cardiac & Cardiovascular Systems
Aaron Guerrero, Bruna Visniauskas, Pilar Cardenas, Stefanny M. Figueroa, Jorge Vivanco, Nicolas Salinas-Parra, Patricio Araos, Quynh My Nguyen, Modar Kassan, Cristian A. Amador, Minolfa C. Prieto, Alexis A. Gonzalez
Summary: Research indicates that in diabetic conditions, high glucose leads to increased levels of intratubular alpha KG and OXGR1-dependent PRR upregulation in collecting duct cells, ultimately affecting AngII formation and Na+ reabsorption.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Urology & Nephrology
Maria Jose Soler, Aida Ribera, Josep R. Marsal, Ana Belen Mendez, Mireia Andres, Maria Antonia Azancot, Gerard Oristrell, Leonardo Mendez-Boo, Jordana Cohen, Jose A. Barrabes, Ignacio Ferreira-Gonzalez
Summary: In a cohort study of HTN patients, it was found that the use of ACEi/ARBs reduced the risk of COVID-19 infection without increasing disease severity.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Oncology
Huirong Jiang, Zongguang Tai, Zhongjian Chen, Quangang Zhu, Leilei Bao
Summary: The renin-angiotensin system plays a crucial role in the development of malignant tumors, and long-term use of RAS inhibitors can lower the risk of cancer. Blocking RAS has been shown to inhibit tumor growth, metastasis, and angiogenesis in malignant tumors.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Physiology
Jiajia Hu, Yandan Tan, Yanting Chen, Shiqi Mo, Brittin Hekking, Jiahui Su, Min Pu, Aihua Lu, Yanhua Du, J. David Symons, Tianxin Yang
Summary: This study demonstrates that activation of the (pro)renin receptor plays a role in cyclosporin A-induced nephropathy by activating the renin-angiotensin system. Antagonism with PRO20 is identified as a novel intervention in managing the side effects of cyclosporin A.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Jon Danel Solano-Iturri, Enrique Echevarria, Miguel Unda, Ana Loizaga-Iriarte, Amparo Perez-Fernandez, Javier C. Angulo, Jose Lopez, Gorka Larrinaga
Summary: The study found that PRR is associated with the development and progression of renal tumors, with high expression at the tumor center and infiltrative front being significantly correlated with high grade, tumor diameter, local invasion, and stage, as well as high mortality risk. The potential of PRR as a novel biomarker for RCC diagnosis/prognosis and as a promising therapeutic target should be considered for the future.
Review
Cardiac & Cardiovascular Systems
Boyang Wang, Haipeng Jie, Shuangxi Wang, Bo Dong, Yunzeng Zou
Summary: (Pro)renin receptor (PRR) is a component of the renin-angiotensin system (RAS) and is involved in the pathogenesis of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on various cardiovascular conditions, including hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Medicine, Research & Experimental
Nehal R. Patel, K. C. Rajan, Avery Blanks, Yisu Li, Minolfa C. Prieto, Stryder M. Meadows
Summary: This study investigates the role of ATP6AP2 in blood vessel development using a mouse model and demonstrates its critical role in developmental and pathological angiogenesis, highlighting its regulatory functions in cell migration, cell polarity, and extracellular matrix composition.
