Article
Pharmacology & Pharmacy
Jun Zhang, Zunyuan Yang, Xue Jia, Xinxin Li, Xiangyang Wang, Hua Rong, Yinan Liang, Wen Zeng, Wei Jia, Xiaohui Ma
Summary: The study demonstrated that QSYQ (T101) significantly improved systolic and diastolic function in rhesus monkeys with spontaneous chronic heart failure, as well as lowered blood pressure and improved ventricular remodeling in Spontaneous Hypertension Rats (SHR) model. Computational prediction suggests that QSYQ (T101) may exert its anti-HF effects through various signaling pathways, while metabolomics analysis revealed its regulation on abnormal metabolites involved in myocardial energy metabolism pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Frank Yu, Bianca McLean, Mitesh Badiwala, Filio Billia
Summary: Cardiovascular disease is the leading cause of mortality globally, with heart failure affecting millions of people. The use of metabolomics and lipidomics has improved our understanding of heart failure and revealed new pathways and potential interventions. The discovery of metabolic effects of heart failure drugs, particularly sodium-glucose transport protein 2 inhibitors, has revolutionized the treatment of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Henry Sutanto, Dobromir Dobrev, Jordi Heijman
Summary: The RAAS system plays a crucial role in cardiovascular health and disease, with short-term activation being beneficial but long-term activation detrimental. Natriuretic peptides are activated to counterbalance the effects of RAAS, facilitating water and salt excretion and causing vasodilation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Soeren J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman J. Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuss, Tim Seidler, Andreas Schuster
Summary: Real-time cardiac magnetic resonance (RT-CMR) exercise imaging can accurately diagnose HFpEF, providing a suitable noninvasive diagnostic alternative, which may be beneficial for routine clinical use pending further multicenter studies.
Article
Critical Care Medicine
Marc W. Heidorn, Stefanie Steck, Felix Mueller, Sven-Oliver Troebs, Gregor Buch, Andreas Schulz, Soeren Schwuchow-Thonke, Alexander Schuch, Konstantin Strauch, Irene Schmidtmann, Karl J. Lackner, Tommaso Gori, Thomas Muenzel, Philipp S. Wild, Jurgen H. Prochaska
Summary: This study aimed to investigate the relationship between pulmonary function and the progression of chronic heart failure (HF). The findings showed that FEV1 was independently associated with deteriorated left ventricle function and hypertrophy, and it was a strong predictor of worsening of HF.
Review
Medicine, General & Internal
Shigehiko Ogoh, Jun Sugawara, Shigeki Shibata
Summary: Heart failure (HF) in patients may increase the risk of cognitive dysfunction and stroke due to physiological factors associated with cardiac dysfunctions affecting cerebral circulation. Reduced cerebral blood flow and abnormal autoregulation in chronic HF can lead to decreased perfusion, metabolic insufficiency, and structural deteriorations in the brain. The mechanism underlying HF-induced brain disease is still unclear, and future studies should focus on physiological factors to prevent brain disease and cardiovascular dysfunction in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Zhanhao Su, Yiwei Liu, Hao Zhang
Summary: Chronic hypoxia plays a crucial role in many cardiac diseases, affecting the heart's metabolic processes. However, the exact mechanisms of adaptive cardiac metabolism in response to chronic hypoxia are still not fully understood. New findings from animal and human studies are summarized to illustrate these mechanisms and potential treatment strategies in patients with chronic hypoxia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christoph Maack, Jil C. Tardiff
Summary: Heart failure is a systemic disease that can impair cardiac function through neuroendocrine activation, inflammation, and metabolic changes. Additionally, genetic variants in sarcomeric protein genes can predispose individuals to develop heart failure. The 2022 Gordon Research Conference aims to identify novel treatment targets for complex cardiac disorders through high-resolution approaches.
NATURE REVIEWS CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Ziying Lin, Louisa Y. F. Wong, Bernard M. Y. Cheung
Summary: Diuretic-induced hypokalaemia is a common and potentially life-threatening adverse drug reaction, which may lead to cardiovascular events and mortality. The most effective treatments for hypokalaemia include reducing diuretic dose, potassium supplementation, and combining with a potassium-sparing diuretic or blocker of the renin-angiotensin system.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yu Zhou, Shibao Rui, Shengxin Tang, Changlin Ju
Summary: This study investigates the antiarrhythmic mechanism of Sacubitril/valsartan (SV) using bioinformatics methods and identifies core target genes and signaling pathways associated with antiarrhythmic effects. The findings may contribute to the development of novel drugs for the treatment of cardiac arrhythmia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Li Shen, Pardeep Singh Jhund, Kieran Francis Docherty, Muthiah Vaduganathan, Mark Colquhoun Petrie, Akshay Suvas Desai, Lars Kober, Morten Schou, Milton Packer, Scott David Solomon, Xingwei Zhang, John Joseph Valentine McMurray
Summary: Previous guidelines for treating heart failure with reduced ejection fraction recommended initiating therapy in a chronological order based on trial history. However, this study suggests that accelerating treatment titration and optimizing treatment ordering may improve patient outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Altmann, Moritz C. Halfmann, Ibukun Abidoye, Basel Yacoub, Michaela Schmidt, Philip Wenzel, Christoph Forman, U. Joseph Schoepf, Fei Xiong, Christoph Dueber, Karl-Friedrich Kreitner, Akos Varga-Szemes, Tilman Emrich
Summary: Highly accelerated compressed sensing (CS)-based cine sequences showed significant reduction in acquisition time compared to conventional (Conv) cine imaging, with significant differences in atrial parameters but high correlation between the two techniques. CS-based parameters demonstrated equivalent diagnostic ability to differentiate between healthy volunteers and heart failure patients when compared to Conv cine imaging.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Silvia Oghina, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Melanie Bezard, Fabien Le Bras, Jean-Francois Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, Diane Bodez
Summary: All LVDF patterns can be observed in CA, and one quarter of CA patients have a better prognosis with grade I LVDF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Emilie Dubois-Deruy, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, Jean-Sebastien Annicotte
Summary: Lysine acetylation is a conserved mechanism that affects various biological processes, and its dysregulation is associated with cardiac dysfunction. This review summarizes the regulation of cardiac acetylation and its roles in both physiological and pathological conditions, highlighting its importance in cardiovascular diseases and suggesting KATs and KDACs as potential therapeutic targets for heart failure.
Article
Cardiac & Cardiovascular Systems
Charles Fauvel, Guillaume Bonnet, Wilfried Mullens, Clara Ines Saldarriaga Giraldo, Anja Zupan Meznar, Anders Barasa, Mariya Tokmakova, Anastasia Shchendrygina, Francisco Moscoso Costa, Massimo Mapelli, Filip Zemrak, Laurens F. Tops, Nina Jakus, Arian Sultan, Fadel Bahouth, Chahr-Eddine Hadjseyd, Muriel Salvat, Matteo Anselmino, Daniel Messroghli, Vanessa Weberndorfer, Ilya Giverts, Thomas Bochaton, Emmanuelle Berthelot, Damien Legallois, Florence Beauvais, Fabrice Bauer, Nicolas Lamblin, Thibaud Damy, Nicolas Girerd, Laurent Sebbag, Theo Pezel, Alain Cohen-Solal, Giuseppe Rosano, Francois Roubille, Nathan Mewton
Summary: This study aimed to understand the perception of practicing cardiologists and heart failure (HF) specialists regarding the recommendation of initiating four major therapeutic classes simultaneously in patients with heart failure and reduced ejection fraction. The survey findings showed that most cardiologists still preferred the historical approach of sequential initiation, although accelerated introduction and titration were also considered important treatment goals.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)