Adenosine(1) Receptor Antagonism A New Therapeutic Approach for the Treatment of Decompensated Heart Failure

Heart failure (HF) remains a major cause of morbidity and mortality, even with the use of standard treatments in patients with chronic HF and acute decompensated. HF. Impaired renal function is an important prognostic indicator for adverse clinical outcome. Elevated plasma levels of adenosine have been observed in HF patients and stimulation of adenosine, receptors (A(1)R) in the kidney may be contributing to impaired renal function and treatment resistance. This observation has led to the development of AIR inhibitor drugs, both in oral and intravenous formulations, which in both animal and preliminary clinical trials have been shown to augment diuresis while preserving or improving renal function in HF patients. An extensive phase III clinical program using the AIR KW-3902 is now in progress in patients with symptomatic HF and renal dysfunction to evaluate the efficacy and safety of this treatment approach.