Genetic variation in Toll-like receptors and disease susceptibility

Balancing Selection Is the Main Force Shaping the Evolution of Innate Immunity Genes

(2014) A. Ferrer-Admetlla et al.   JOURNAL OF IMMUNOLOGY

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis

(2011) Valérie Abadie et al.   Annual Review of Immunology

Genetic adaptation of the antibacterial human innate immunity network

(2011) Ferran Casals et al.   BMC EVOLUTIONARY BIOLOGY

Natural Loss-of-function Mutation of Myeloid Differentiation Protein 88 Disrupts Its Ability to Form Myddosomes

(2011) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Evolutionary History of TLR4 Polymorphisms in Europe

(2011) Theo S. Plantinga et al.   Journal of Innate Immunity

Evolution of the TIR Domain-Containing Adaptors in Humans: Swinging between Constraint and Adaptation

(2011) Simona Fornarino et al.   MOLECULAR BIOLOGY AND EVOLUTION

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIRAP Ser180Leu polymorphism is associated with Behcet's disease

(2011) O. Durrani et al.   RHEUMATOLOGY

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility

(2011) Ruifen Miao et al.   TUBERCULOSIS

Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution

(2011) Matteo Fumagalli et al.   PLoS Genetics

Genetic Epidemiology of Tuberculosis Susceptibility: Impact of Study Design

(2011) Catherine M. Stein   PLoS Pathogens

Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection

(2010) Alexandra Zhernakova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury

(2010) Zhenju Song et al.   BMC Medical Genetics

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Primary immunodeficiencies of protective immunity to primary infections

(2010) Aziz Bousfiha et al.   CLINICAL IMMUNOLOGY

Association between Single‐Nucleotide Polymorphisms inMal/TIRAPandInterleukin‐10Genes and Susceptibility to InvasiveHaemophilus influenzaeSerotype b Infection in Immunized Children

(2010) Shamez N. Ladhani et al.   CLINICAL INFECTIOUS DISEASES

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

(2010) Rebeca Pérez de Diego et al.   IMMUNITY

Two HumanMYD88Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly

(2010) Julie George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

Adaptation and Constraint at Toll-Like Receptors in Primates

(2010) G. Wlasiuk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India

(2010) P. Selvaraj et al.   TUBERCULOSIS

Low frequency of the TIRAPS180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

(2009) Lutz Hamann et al.   BMC Medical Genetics

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

A partial form of recessive STAT1 deficiency in humans

(2009) Ariane Chapgier et al.   JOURNAL OF CLINICAL INVESTIGATION

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

(2009) Matteo Fumagalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease

(2009) K. A. Staschke et al.   JOURNAL OF IMMUNOLOGY

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

(2009) E. F. Kenny et al.   JOURNAL OF IMMUNOLOGY

Heterozygosity for the S180L Variant ofMAL/TIRAP,a Gene Expressing an Adaptor Protein in the Toll‐Like Receptor Pathway, Is Associated with Lower Risk of Developing Chronic Chagas Cardiomyopathy

(2009) Rajendranath Ramasawmy et al.   JOURNAL OF INFECTIOUS DISEASES

A History of Recurrent Positive Selection at the Toll-Like Receptor 5 in Primates

(2009) Gabriela Wlasiuk et al.   MOLECULAR BIOLOGY AND EVOLUTION

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women

(2009) Thomas R. Hawn et al.   PLoS One

Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups

(2009) Shobana Rebecca Dissanayeke et al.   PLoS One

Explaining worldwide patterns of human genetic variation using a coalescent-based serial founder model of migration outward from Africa

(2009) M. DeGiorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

(2009) B. Ferwerda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

(2009) Luis B. Barreiro et al.   PLoS Genetics

Toll-like receptor polymorphisms and susceptibility to human disease

(2008) E. Ann Misch et al.   CLINICAL SCIENCE

Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics

(2008) Giorgio Sirugo et al.   HUMAN GENETICS

Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases

(2008) Bruce Beutler   IMMUNOLOGICAL REVIEWS

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

(2008) John Castiblanco et al.   INFECTION GENETICS AND EVOLUTION

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

(2008) Matthijs C Brouwer et al.   LANCET INFECTIOUS DISEASES

Unknown

(2008) Bart Ferwerda et al.   MOLECULAR MEDICINE

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

The spectrum of herpes simplex encephalitis in children

(2007) Xavier De Tiège et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY