Evolution of the TIR Domain-Containing Adaptors in Humans: Swinging between Constraint and Adaptation

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation

(2010) Jonathan K. Pritchard et al.   CURRENT BIOLOGY

SARM inhibits both TRIF- and MyD88-mediated AP-1 activation

(2010) Jun Peng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A New Test for Detecting Recent Positive Selection that is Free from the Confounding Impacts of Demography

(2010) H. Li   MOLECULAR BIOLOGY AND EVOLUTION

Adaptation and Constraint at Toll-Like Receptors in Primates

(2010) G. Wlasiuk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

(2010) Bing He et al.   NATURE IMMUNOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Adaptation – not by sweeps alone

(2010) Jonathan K. Pritchard et al.   NATURE REVIEWS GENETICS

Formulating a Historical and Demographic Model of Recent Human Evolution Based on Resequencing Data from Noncoding Regions

(2010) Guillaume Laval et al.   PLoS One

Signatures of Purifying and Local Positive Selection in Human miRNAs

(2009) Hélène Quach et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR3

(2009) E. F. Kenny et al.   JOURNAL OF IMMUNOLOGY

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

(2009) B. Ferwerda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

(2009) Luis B. Barreiro et al.   PLoS Genetics

Natural selection on the Drosophila antimicrobial immune system

(2008) Brian P Lazzaro   CURRENT OPINION IN MICROBIOLOGY

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

Low Levels of Polymorphism in Genes That Control the Activation of Defense Response in Arabidopsis thaliana

(2008) E. G. Bakker et al.   GENETICS

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

Natural selection in the TLR-related genes in the course of primate evolution

(2008) Toshiaki Nakajima et al.   IMMUNOGENETICS

MyDths and un-TOLLed truths: Sensor, instructive and effector immunity to tuberculosis

(2008) Norbert Reiling et al.   IMMUNOLOGY LETTERS

Natural selection has driven population differentiation in modern humans

(2008) Luis B Barreiro et al.   NATURE GENETICS

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

(2008) J. Z. Li et al.   SCIENCE

High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation

(2008) Jean-Baptiste Veyrieras et al.   PLoS Genetics

SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human

(2007) Loh Wei-Ching Belinda et al.   MOLECULAR IMMUNOLOGY