Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population

(2011) Y.X. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Improved molecular replacement by density- and energy-guided protein structure optimization

(2011) Frank DiMaio et al.   NATURE

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Joint X-ray and neutron refinement withphenix.refine

(2010) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Association between Single‐Nucleotide Polymorphisms inMal/TIRAPandInterleukin‐10Genes and Susceptibility to InvasiveHaemophilus influenzaeSerotype b Infection in Immunized Children

(2010) Shamez N. Ladhani et al.   CLINICAL INFECTIOUS DISEASES

IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal)

(2010) Aisling Dunne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

(2010) P. Ulrichts et al.   JOURNAL OF CELL SCIENCE

Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

(2010) X. Wittebole et al.   MEDIATORS OF INFLAMMATION

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

TIR-containing adaptors in Toll-like receptor signalling

(2009) Kristie A. Jenkins et al.   CYTOKINE

Molecular Mimicry in Innate Immunity

(2009) Siew Leong Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2- and TLR4-mediated NF-κB Proinflammatory Responses

(2009) Brett Verstak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular basis of the host response to lipopolysaccharide

(2009) Clare E. Bryant et al.   NATURE REVIEWS MICROBIOLOGY

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

(2009) B. Ferwerda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baseless Assumptions: Activation of TLR9 by DNA

(2008) Monique Gangloff et al.   IMMUNITY

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly reflects evolution of protein complexes

(2008) Emmanuel D. Levy et al.   NATURE

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE