The toxicity of silica nanoparticles to the immune system

The size-dependent effects of silica nanoparticles on endothelial cell apoptosis through activating the p53-caspase pathway

(2018) Wuxiang Wang et al.   ENVIRONMENTAL POLLUTION

Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Relationship between lymphocyte DNA fragmentation and dose of iron oxide (Fe2O3) and silicon oxide (SiO2) nanoparticles

(2017) J. Jiménez-Villarreal et al.   GENETICS AND MOLECULAR RESEARCH

The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

(2017) Xiaoyuan Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silica nanoparticles induce liver fibrosis via TGF-β1/Smad3 pathway in ICR mice

(2017) Yang Yu et al.   International Journal of Nanomedicine

Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes

(2017) Ji Wang et al.   International Journal of Nanomedicine

Asymmetric Silica Nanoparticles with Tunable Head–Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells

(2017) Prasanna Lakshmi Abbaraju et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extra-Large Pore Mesoporous Silica Nanoparticles for Directing in Vivo M2 Macrophage Polarization by Delivering IL-4

(2017) Dohyeong Kwon et al.   NANO LETTERS

Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles

(2017) Bastien Dalzon et al.   Nanoscale

Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice

(2017) Takayuki Handa et al.   NANOTECHNOLOGY

Differential cytotoxic and inflammatory potency of amorphous silicon dioxide nanoparticles of similar size in multiple cell lines

(2017) Dalibor Breznan et al.   Nanotoxicology

MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica

(2017) Hans Christian Winkler et al.   Particle and Fibre Toxicology

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

(2017) James L. Weaver et al.   Particle and Fibre Toxicology

SiO2 and TiO2 nanoparticles synergistically trigger macrophage inflammatory responses

(2017) Misato Tsugita et al.   Particle and Fibre Toxicology

Autophagy induced by silica nanoparticles protects RAW264.7 macrophages from cell death

(2017) Clarissa Marquardt et al.   TOXICOLOGY

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity

(2017) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells

(2017) S. Siegrist et al.   TOXICOLOGY IN VITRO

Bioinformatics methods for identifying differentially expressed genes and signaling pathways in nano-silica stimulated macrophages

(2017) Lin Zhang et al.   TUMOR BIOLOGY

Metabolic Reprogramming of Macrophages Exposed to Silk, Poly(lactic-co -glycolic acid), and Silica Nanoparticles

(2017) Raquel Saborano et al.   Advanced Healthcare Materials

SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation

(2017) Misato Tsugita et al.   Cell Reports

Specific Surface Modifications of Silica Nanoparticles Diminish Inflammasome Activation and In Vivo Expression of Selected Inflammatory Genes

(2017) Viviana Marzaioli et al.   Nanomaterials

The Effects of Silica Nanoparticles on Apoptosis and Autophagy of Glioblastoma Cell Lines

(2017) Rafał Krętowski et al.   Nanomaterials

Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific

(2017) Nobuo Nishijima et al.   Frontiers in Immunology

New findings of silica nanoparticles induced ER autophagy in human colon cancer cell

(2017) Fujing Wei et al.   Scientific Reports

An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration

(2017) Martha Kim et al.   Scientific Reports

Differential Protein Adsorption and Cellular Uptake of Silica Nanoparticles Based on Size and Porosity

(2016) Jiban Saikia et al.   ACS Applied Materials & Interfaces

Impact of fluorescent silicon nanoparticles on circulating hemolymph and hematopoiesis in an invertebrate model organism

(2016) Rui Xing et al.   CHEMOSPHERE

Cytotoxicity and DNA damage in mouse macrophages exposed to silica nanoparticles

(2016) H. Yang et al.   GENETICS AND MOLECULAR RESEARCH

Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation

(2016) Chen Xi et al.   INFLAMMATION RESEARCH

Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation

(2016) Man Yang et al.   International Journal of Nanomedicine

Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis

(2016) Stefan Pfuhler et al.   MUTAGENESIS

Evaluation of endocytosis of silica particles used in biodegradable implants in the brain

(2016) Jana Zielinski et al.   Nanomedicine-Nanotechnology Biology and Medicine

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

(2016) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silica nanoparticles activate purinergic signaling via P2X 7 receptor in dendritic cells, leading to production of pro-inflammatory cytokines

(2016) Kana Nakanishi et al.   TOXICOLOGY IN VITRO

Kinetics of chemotaxis, cytokine, and chemokine release of NR8383 macrophages after exposure to inflammatory and inert granular insoluble particles

(2016) I. Schremmer et al.   TOXICOLOGY LETTERS

Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles

(2016) Serge Zhuravskii et al.   TOXICOLOGY MECHANISMS AND METHODS

Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles

(2016) Serge Zhuravskii et al.   TOXICOLOGY MECHANISMS AND METHODS

Silica nanoparticle-generated ROS as a predictor of cellular toxicity: mechanistic insights and safety by design

(2016) Sean E. Lehman et al.   Environmental Science-Nano

Macrophage silica nanoparticle response is phenotypically dependent

(2015) Heather L. Herd et al.   BIOMATERIALS

Cytotoxic and genotoxic characterization of aluminum and silicon oxide nanoparticles in macrophages

(2015) Masanori Hashimoto et al.   DENTAL MATERIALS

Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro

(2015) S Rajiv et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

A mechanistic review of silica-induced inhalation toxicity

(2015) Hajime Kawasaki   INHALATION TOXICOLOGY

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

(2015) Caixia Guo et al.   International Journal of Nanomedicine

In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials

(2015) Elena Maser et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos

(2015) Junchao Duan et al.   Nanotoxicology

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Revisiting the paradigm of silica pathogenicity with synthetic quartz crystals: the role of crystallinity and surface disorder

(2015) Francesco Turci et al.   Particle and Fibre Toxicology

The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles

(2015) Virginie Rabolli et al.   Particle and Fibre Toxicology

Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells

(2015) Luisana Di Cristo et al.   TOXICOLOGICAL SCIENCES

Comparative safety evaluation of silica-based particles

(2015) Helene Kettiger et al.   TOXICOLOGY IN VITRO

Particle-induced cell migration assay (PICMA): A new in vitro assay for inflammatory particle effects based on permanent cell lines

(2015) Götz A. Westphal et al.   TOXICOLOGY IN VITRO

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles

(2015) Peilin Yu et al.   Scientific Reports

M2 polarization enhances silica nanoparticle uptake by macrophages

(2015) Jessica Hoppstädter et al.   Frontiers in Pharmacology

Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells

(2014) Alvaro Mendoza et al.   CELL STRESS & CHAPERONES

SiO2Nanoparticule-induced size-dependent genotoxicity – anin vitrostudy using sister chromatid exchange, micronucleus and comet assay

(2014) Dilek Battal et al.   DRUG AND CHEMICAL TOXICOLOGY

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure, part 2: Intratracheal instillation and intravenous injection

(2014) Yves Guichard et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants

(2014) Silke Neumann et al.   IMMUNOLOGY AND CELL BIOLOGY

Undetactable levels of genotoxicity of SiO2 nanoparticles in in vitro and in vivo tests

(2014) Seong Soo A. An et al.   International Journal of Nanomedicine

Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge

(2014) Soo-Ki Kim et al.   International Journal of Nanomedicine

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

(2014) Duan et al.   International Journal of Nanomedicine

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

(2014) Junchao Duan et al.   Particle and Fibre Toxicology

The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

(2014) Virginie Rabolli et al.   Particle and Fibre Toxicology

Effect of Silica Particle Size on Macrophage Inflammatory Responses

(2014) Toshimasa Kusaka et al.   PLoS One

Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle

(2014) Shuji Kojima et al.   TOXICOLOGY

Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation

(2013) Kunal Bhattacharya et al.   ADVANCED DRUG DELIVERY REVIEWS

The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes

(2013) Changhui Fu et al.   BIOMATERIALS

In Vitro Study of Interactions between Silicon-Containing Nanoparticles and Human Peripheral Blood Leukocytes

(2013) E. R. Andreeva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Assessment of Nanoparticle Exposure in Nanosilica Handling Process: Including Characteristics of Nanoparticles Leaking from a Vacuum Cleaner

(2013) Boowook KIM et al.   INDUSTRIAL HEALTH

Genotoxicity of amorphous silica particles with different structure and dimension in human and murine cell lines

(2013) P. Guidi et al.   MUTAGENESIS

Nonporous silica nanoparticles for nanomedicine application

(2013) Li Tang et al.   Nano Today

Acute Toxicity of Amorphous Silica Nanoparticles in Intravenously Exposed ICR Mice

(2013) Yang Yu et al.   PLoS One

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

(2013) Junchao Duan et al.   PLoS One

Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes

(2013) Ana M. Tavares et al.   TOXICOLOGY IN VITRO

The Effects of Silica Nanoparticles in Macrophage Cells

(2013) Seungjae Kim et al.   Immune Network

Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells

(2012) Toshiro Hirai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Silica-based nanoparticles for biomedical applications

(2012) Ahmad Bitar et al.   DRUG DISCOVERY TODAY

Size of submicrometric and nanometric particles affect cellular uptake and biological activity of macrophagesin vitro

(2012) L. Leclerc et al.   INHALATION TOXICOLOGY

In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics

(2012) Tian Yu et al.   JOURNAL OF CONTROLLED RELEASE

Comparison of the cytotoxic and inflammatory responses of titanium particles with different methods for endotoxin removal in RAW264.7 macrophages

(2012) Huifeng Ding et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

Catastrophic inflammatory death of monocytes and macrophages by overtaking of a critical dose of endocytosed synthetic amorphous silica nanoparticles/serum protein complexes

(2012) Chiara Fedeli et al.   Nanomedicine

Effect of surface modification of silica nanoparticles on toxicity and cellular uptake by human peripheral blood lymphocytesin vitro

(2012) Anna Lankoff et al.   Nanotoxicology

Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages

(2012) Wiggo J Sandberg et al.   Particle and Fibre Toxicology

Amorphous Silica Nanoparticles Promote Monocyte Adhesion to Human Endothelial Cells: Size-Dependent Effect

(2012) Dorota Napierska et al.   Small

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

(2012) Bingbing Sun et al.   Small

Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

(2012) Javed Ahmad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro

(2012) Yang Xue et al.   TOXICOLOGY LETTERS

Induction of Functional Changes of Dendritic Cells by Silica Nanoparticles

(2012) Kyeongah Kang et al.   Immune Network

Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity

(2011) Tian Yu et al.   ACS Nano

Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells

(2011) Alexander T. Bauer et al.   BIOMATERIALS

The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis

(2011) Soyoung Lee et al.   BIOMATERIALS

Application of Mesoporous Silicon Dioxide and Silicate in Oral Amorphous Drug Delivery Systems

(2011) Ken K. Qian et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes

(2011) Hiromi Nabeshi et al.   Particle and Fibre Toxicology

The Phagocytosis and Toxicity of Amorphous Silica

(2011) Lindsey M. Costantini et al.   PLoS One

Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells

(2011) Andrea Kunzmann et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: Facts and artefacts

(2011) Verena Wilhelmi et al.   TOXICOLOGY IN VITRO

The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages

(2011) Hiromi Nabeshi et al.   Nanoscale Research Letters

Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages

(2011) Hiromi Nabeshi et al.   Nanoscale Research Letters

Functional Assessment of Metal Oxide Nanoparticle Toxicity in Immune Cells

(2010) Melissa A. Maurer-Jones et al.   ACS Nano

Cellular Uptake, Cytotoxicity, and Innate Immune Response of Silica−Titania Hollow Nanoparticles Based on Size and Surface Functionality

(2010) Wan-Kyu Oh et al.   ACS Nano

Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm?

(2010) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cell Membrane Injury Induced by Silica Nanoparticles in Mouse Macrophage

(2010) Hong Yang et al.   Journal of Biomedical Nanotechnology

Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators

(2010) Qin Zhang et al.   Nanotoxicology

Influence of size, surface area and microporosity on thein vitrocytotoxic activity of amorphous silica nanoparticles in different cell types

(2010) Virginie Rabolli et al.   Nanotoxicology

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

Presence and risks of nanosilica in food products

(2010) Susan Dekkers et al.   Nanotoxicology

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The comparative absorption of silicon from different foods and food supplements

(2009) Supannee Sripanyakorn et al.   BRITISH JOURNAL OF NUTRITION

Silica-Based Nanoparticle Uptake and Cellular Response by Primary Microglia

(2009) Judy Choi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells

(2009) Dorota Napierska et al.   Small

The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles

(2009) Minjung Cho et al.   TOXICOLOGY LETTERS

Size-dependent hydroxyl radicals generation induced by SiO2 ultra-fine particles: The role of surface iron

(2009) Yu Shang et al.   Science in China. Series B, Chemistry

Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆

(2008) I SLOWING et al.   ADVANCED DRUG DELIVERY REVIEWS

Comparison of cytotoxic and inflammatory responses of photoluminescent silicon nanoparticles with silicon micron-sized particles in RAW 264.7 macrophages

(2008) Jonghoon Choi et al.   JOURNAL OF APPLIED TOXICOLOGY

Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition

(2008) Hui Yang et al.   JOURNAL OF APPLIED TOXICOLOGY

Nanoparticulate-induced toxicity and related mechanism in vitro and in vivo

(2008) Hye Won Kim et al.   JOURNAL OF NANOPARTICLE RESEARCH

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Nanosilica—from medicine to pest control

(2008) T. K. Barik et al.   PARASITOLOGY RESEARCH

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes

(2008) Katrina M. Waters et al.   TOXICOLOGICAL SCIENCES

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS