Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles

Autophagy induced by silica nanoparticles protects RAW264.7 macrophages from cell death

(2017) Clarissa Marquardt et al.   TOXICOLOGY

Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epithelial BEAS-2B cells

(2016) Jing Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Cytotoxicity and DNA damage in mouse macrophages exposed to silica nanoparticles

(2016) H. Yang et al.   GENETICS AND MOLECULAR RESEARCH

Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation

(2016) Chen Xi et al.   INFLAMMATION RESEARCH

Relationship between size and surface modification of silica particles and enhancement and suppression of inflammatory cytokine production by lipopolysaccharide- or peptidoglycan-stimulated RAW264.7 macrophages

(2016) Eiichiro Uemura et al.   JOURNAL OF NANOPARTICLE RESEARCH

A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages

(2016) Catherine Aude-Garcia et al.   Journal of Proteomics

Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents

(2016) Lucie Armand et al.   Nanotoxicology

Culture medium associated changes in the core proteome of macrophages and in their responses to copper oxide nanoparticles

(2016) Bastien Dalzon et al.   PROTEOMICS

Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function during Nanoparticle-Induced Oxidative Stress

(2015) Jicheng Duan et al.   ACS Nano

High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field

(2015) Cédric Pisani et al.   BMC GENOMICS

Cytotoxic and genotoxic characterization of aluminum and silicon oxide nanoparticles in macrophages

(2015) Masanori Hashimoto et al.   DENTAL MATERIALS

Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells

(2015) Chun-Feng Lu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles

(2015) Virginie Rabolli et al.   Particle and Fibre Toxicology

Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells

(2015) Luisana Di Cristo et al.   TOXICOLOGICAL SCIENCES

Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line

(2015) Adeline Tarantini et al.   TOXICOLOGY IN VITRO

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages

(2015) Sarah Triboulet et al.   PLoS One

Silica nanoparticle induces oxidative stress and provokes inflammation in human lung cells

(2014) Devashri Sahu et al.   Journal of Experimental Nanoscience

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach

(2014) Sarah Triboulet et al.   Nanoscale

The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

(2014) Virginie Rabolli et al.   Particle and Fibre Toxicology

Effect of Silica Particle Size on Macrophage Inflammatory Responses

(2014) Toshimasa Kusaka et al.   PLoS One

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

(2014) Dominic Docter et al.   Beilstein Journal of Nanotechnology

Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles

(2013) Vamsi Kodali et al.   ACS Nano

Particle-size-dependent cytokine responses and cell damage induced by silica particles and macrophages-derived mediators in endothelial cell

(2013) Yi Rong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice

(2013) Mingchun Guo et al.   JOURNAL OF HAZARDOUS MATERIALS

Myoglobin on Silica: A Case Study of the Impact of Adsorption on Protein Structure and Dynamics

(2013) Stéphanie Devineau et al.   LANGMUIR

Molecular Responses of Mouse Macrophages to Copper and Copper Oxide Nanoparticles Inferred from Proteomic Analyses

(2013) Sarah Triboulet et al.   MOLECULAR & CELLULAR PROTEOMICS

Genotoxicity of amorphous silica particles with different structure and dimension in human and murine cell lines

(2013) P. Guidi et al.   MUTAGENESIS

Dynamic development of the protein corona on silica nanoparticles: composition and role in toxicity

(2013) Ninell P. Mortensen et al.   Nanoscale

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

(2013) Junchao Duan et al.   PLoS One

Interindividual Variation in the Proteome of Human Peripheral Blood Mononuclear Cells

(2013) Evelyne Maes et al.   PLoS One

Elucidation of Toxicity Pathways in Lung Epithelial Cells Induced by Silicon Dioxide Nanoparticles

(2013) Odu Okoturo-Evans et al.   PLoS One

Total variance should drive data handling strategies in third generation proteomic studies

(2013) Abigail G. Herrmann et al.   PROTEOMICS

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

(2012) Anna Lesniak et al.   ACS Nano

Oxidative Stress Induced by Pure and Iron-Doped Amorphous Silica Nanoparticles in Subtoxic Conditions

(2012) Dorota Napierska et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanistic insights into the regulation of metabolic enzymes by acetylation

(2012) Yue Xiong et al.   JOURNAL OF CELL BIOLOGY

Quantitative analysis of the intra- and inter-subject variability of the whole salivary proteome

(2012) N. Jehmlich et al.   JOURNAL OF PERIODONTAL RESEARCH

How Do Proteins Unfold upon Adsorption on Nanoparticle Surfaces?

(2012) Hai Pan et al.   LANGMUIR

Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

(2012) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Screening of different metal oxide nanoparticles reveals selective toxicity and inflammatory potential of silica nanoparticles in lung epithelial cells and macrophages

(2012) A. Panas et al.   Nanotoxicology

Mechanisms of toxicity induced by SiO2nanoparticles ofin vitrohuman alveolar barrier: effects on cytokine production, oxidative stress induction, surfactant proteins A mRNA expression and nanoparticles uptake

(2012) Lucian Romeo Farcal et al.   Nanotoxicology

Cytokine production by co-cultures exposed to monodisperse amorphous silica nanoparticles: The role of size and surface area

(2012) Dorota Napierska et al.   TOXICOLOGY LETTERS

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Differential toxicity of amorphous silica nanoparticles toward phagocytic and epithelial cells

(2011) Alexander Malugin et al.   JOURNAL OF NANOPARTICLE RESEARCH

In vitro evaluation of cytotoxic and inflammatory properties of silica nanoparticles of different sizes in murine RAW 264.7 macrophages

(2011) Margriet V. D. Z. Park et al.   JOURNAL OF NANOPARTICLE RESEARCH

Multiple Hypothesis Testing in Proteomics: A Strategy for Experimental Work

(2011) Angel P. Diz et al.   MOLECULAR & CELLULAR PROTEOMICS

Assessment of side-effects by Ludox TMA silica nanoparticles following a dietary exposure on the bumblebeeBombus terrestris

(2011) Veerle Mommaerts et al.   Nanotoxicology

Regulation of the arachidonic acid mobilization in macrophages by combustion-derived particles

(2011) Susanne Fritsch-Decker et al.   Particle and Fibre Toxicology

The Phagocytosis and Toxicity of Amorphous Silica

(2011) Lindsey M. Costantini et al.   PLoS One

The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

Probing the Active Site of the DeoxynucleotideN-Hydrolase Rcl Encoded by the Rat Gene c6orf108

(2010) Christelle Dupouy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of size, surface area and microporosity on thein vitrocytotoxic activity of amorphous silica nanoparticles in different cell types

(2010) Virginie Rabolli et al.   Nanotoxicology

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells

(2010) Xifei Yang et al.   Particle and Fibre Toxicology

Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells

(2010) Mohd Javed Akhtar et al.   TOXICOLOGY

Solution Structure of RCL, a Novel 2′-Deoxyribonucleoside 5′-Monophosphate N-glycosidase

(2009) Kiran Doddapaneni et al.   JOURNAL OF MOLECULAR BIOLOGY

Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes

(2009) Mark A Merkley et al.   Proteome Science

Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells

(2009) Dorota Napierska et al.   Small

Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells

(2009) J. Palomäki et al.   TOXICOLOGY

Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes

(2008) Katrina M. Waters et al.   TOXICOLOGICAL SCIENCES

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS