The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33

(2014) A. M. Shadie et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-33 modulates chronic airway resistance changes induced by multi-walled carbon nanotubes

(2014) Xiaojia Wang et al.   INHALATION TOXICOLOGY

Critical Role of Aquaporins in Interleukin 1β (IL-1β)-induced Inflammation

(2014) Virginie Rabolli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Free radical scavenging and formation by multi-walled carbon nanotubes in cell free conditions and in human bronchial epithelial cells

(2014) Penny Nymark et al.   Particle and Fibre Toxicology

Uncoupling between Inflammatory and Fibrotic Responses to Silica: Evidence from MyD88 Knockout Mice

(2014) Sandra Lo Re et al.   PLoS One

Changes in protein expression in rat bronchoalveolar lavage fluid after exposure to zinc oxide nanoparticles: an iTRAQ proteomic approach

(2014) Yu-Min Juang et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice

(2013) Jiali Guo et al.   ARCHIVES OF TOXICOLOGY

In Search of the Chemical Basis of the Hemolytic Potential of Silicas

(2013) Cristina Pavan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Endogenous IL-1α is a chromatin-associated protein in mouse macrophages

(2013) Céline Lamacchia et al.   CYTOKINE

IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts

(2013) M I Suwara et al.   Mucosal Immunology

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

(2013) Tina M. Sager et al.   Nanotoxicology

Effect of MWCNT size, carboxylation, and purification on in vitro and in vivo toxicity, inflammation and lung pathology

(2013) Raymond F Hamilton et al.   Particle and Fibre Toxicology

Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells

(2013) Jedd M Hillegass et al.   Particle and Fibre Toxicology

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

(2013) Paul M Peeters et al.   Particle and Fibre Toxicology

In vitro human skin irritation test for evaluation of medical device extracts

(2013) J.W. Casas et al.   TOXICOLOGY IN VITRO

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-1-Dependent Sterile Inflammatory Response Has a Substantial Caspase-1-Independent Component That Requires Cathepsin C

(2012) H. Kono et al.   JOURNAL OF IMMUNOLOGY

Association Between Proinflammatory Responses of Respirable Silica Dust and Adverse Health Effects Among Dust-Exposed Workers

(2012) Ting Zhou et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung

(2012) Celine A. Beamer et al.   Nanotoxicology

Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages

(2012) Wiggo J Sandberg et al.   Particle and Fibre Toxicology

A Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL-33/ST2 Axis

(2012) Pranita Katwa et al.   Small

Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes

(2012) Dain Son et al.   TOXICOLOGY LETTERS

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Role of IL-1  and the Nlrp3/caspase-1/IL-1  axis in cigarette smoke-induced pulmonary inflammation and COPD

(2011) N. S. Pauwels et al.   EUROPEAN RESPIRATORY JOURNAL

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles

(2011) Anna C. Reisetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

(2011) A. B. Van Belle et al.   JOURNAL OF IMMUNOLOGY

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

(2011) Etienne Meunier et al.   Nanomedicine-Nanotechnology Biology and Medicine

The Phagocytosis and Toxicity of Amorphous Silica

(2011) Lindsey M. Costantini et al.   PLoS One

IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

(2011) Fernando M. Botelho et al.   PLoS One

Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1 

(2011) Y. Berda-Haddad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

(2011) Heidi Wähämaa et al.   ARTHRITIS RESEARCH & THERAPY

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm?

(2010) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear retention of IL-1α by necrotic cells: A mechanism to dampen sterile inflammation

(2009) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Assessment of human epidermal model LabCyte EPI-MODEL for in vitro skin irritation testing according to European Centre for the Validation of Alternative Methods (ECVAM)-validated protocol

(2009) Masakazu Katoh et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Synthesis and Characterization of Stable Monodisperse Silica Nanoparticle Sols forin VitroCytotoxicity Testing

(2009) Leen C. J. Thomassen et al.   LANGMUIR

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Particles from wood smoke and traffic induce differential pro-inflammatory response patterns in co-cultures

(2008) Anette Kocbach et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ozone Exposure of Macrophages Induces an Alveolar Epithelial Chemokine Response through IL-1α

(2007) Rizwan Manzer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY