Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms
Authors
Keywords
-
Journal
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Volume 78, Issue 3, Pages 343-371
Publisher
American Society for Microbiology
Online
2014-09-03
DOI
10.1128/mmbr.00010-14
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Characterization of a Novel Necrotic Granuloma Model of Latent Tuberculosis Infection and Reactivation in Mice
- (2014) Noton K. Dutta et al. AMERICAN JOURNAL OF PATHOLOGY
- Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response
- (2014) T. J. Scriba et al. JOURNAL OF IMMUNOLOGY
- Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
- (2014) Richard E Lee et al. NATURE MEDICINE
- Whole Genome Sequencing of Mycobacterium tuberculosis Reveals Slow Growth and Low Mutation Rates during Latent Infections in Humans
- (2014) Roberto Colangeli et al. PLoS One
- Systems Biology-Based Identification of Mycobacterium tuberculosis Persistence Genes in Mouse Lungs
- (2014) N. K. Dutta et al. mBio
- Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor
- (2013) Shashank Gupta et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Efficacy and Safety of Metronidazole for Pulmonary Multidrug-Resistant Tuberculosis
- (2013) Matthew W. Carroll et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis
- (2013) Selvakumar Subbian et al. Cell Communication and Signaling
- Vaccine Development for Tuberculosis: Current Progress
- (2013) Ian M. Orme DRUGS
- Tuberculosis biomarkers discovery: developments, needs, and challenges
- (2013) Robert S Wallis et al. LANCET INFECTIOUS DISEASES
- Is tuberculosis a lymphatic disease with a pulmonary portal?
- (2013) Marcel A Behr et al. LANCET INFECTIOUS DISEASES
- Polymorphisms of the NRAMP1 gene: Distribution and susceptibility to the development of pulmonary tuberculosis in the Greek population
- (2013) Marios K. Stagas et al. MEDICAL SCIENCE MONITOR
- Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E
- (2013) S. Sanyal et al. MICROBIOLOGY-SGM
- Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
- (2013) Philana Ling Lin et al. NATURE MEDICINE
- Treatment of Latent Tuberculosis Infection
- (2013) Andrew Vernon SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Advances in the Diagnosis of Latent Tuberculosis Infection
- (2013) Neil Schluger SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
- Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis
- (2013) D. Sambandan et al. mBio
- The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence
- (2013) Y.-M. Chuang et al. mBio
- Adjunctive immunotherapy with α-crystallin based DNA vaccination reduces Tuberculosis chemotherapy period in chronically infected mice
- (2013) Priyanka Chauhan et al. Scientific Reports
- The Antibiotic Resistance Arrow of Time: Efflux Pump Induction Is a General First Step in the Evolution of Mycobacterial Drug Resistance
- (2012) Aurelia M. Schmalstieg et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Targeting Persisters for Tuberculosis Control
- (2012) Ying Zhang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- WhiB5, a Transcriptional Regulator That Contributes to Mycobacterium tuberculosis Virulence and Reactivation
- (2012) Stefano Casonato et al. INFECTION AND IMMUNITY
- MprAB Regulates the espA Operon in Mycobacterium tuberculosis and Modulates ESX-1 Function and Host Cytokine Response
- (2012) X. Pang et al. JOURNAL OF BACTERIOLOGY
- The Dormancy Regulator DosR Controls Ribosome Stability in Hypoxic Mycobacteria
- (2012) Andrej Trauner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Mechanism of Growth Phase-dependent Tolerance to Isoniazid in Mycobacteria
- (2012) Makoto Niki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Growth and Translation Inhibition through Sequence-specific RNA Binding byMycobacterium tuberculosisVapC Toxin
- (2012) Jared D. Sharp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Extrapulmonary Locations of Mycobacterium tuberculosis DNA During Latent Infection
- (2012) Jorge Barrios-Payán et al. JOURNAL OF INFECTIOUS DISEASES
- The Mycobacterium tuberculosis Stress Response Factor SigH Is Required for Bacterial Burden as Well as Immunopathology in Primate Lungs
- (2012) Smriti Mehra et al. JOURNAL OF INFECTIOUS DISEASES
- Global tuberculosis control: lessons learnt and future prospects
- (2012) Christian Lienhardt et al. NATURE REVIEWS MICROBIOLOGY
- The Stress-Response Factor SigH Modulates the Interaction between Mycobacterium tuberculosis and Host Phagocytes
- (2012) Noton K. Dutta et al. PLoS One
- Appropriate DevR (DosR)-Mediated Signaling Determines Transcriptional Response, Hypoxic Viability and Virulence of Mycobacterium tuberculosis
- (2012) Shyamasree De Majumdar et al. PLoS One
- The Two PPX-GppA Homologues from Mycobacterium tuberculosis Have Distinct Biochemical Activities
- (2012) Mei Y. Choi et al. PLoS One
- Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
- (2012) P. L. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- glpX Gene of Mycobacterium tuberculosis: Heterologous Expression, Purification, and Enzymatic Characterization of the Encoded Fructose 1,6-bisphosphatase II
- (2011) Hiten J. Gutka et al. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism
- (2011) Kristin N. Adams et al. CELL
- B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis
- (2011) Mingxia Zhang et al. CELLULAR IMMUNOLOGY
- Clinical Application and Limitations of Interferon- Release Assays for the Diagnosis of Latent Tuberculosis Infection
- (2011) V. Herrera et al. CLINICAL INFECTIOUS DISEASES
- Latent tuberculosis: what the host “sees”?
- (2011) Hannah P. Gideon et al. IMMUNOLOGIC RESEARCH
- Current Concepts in the Management of Tuberculosis
- (2011) Irene G. Sia et al. MAYO CLINIC PROCEEDINGS
- Metabolite-enabled eradication of bacterial persisters by aminoglycosides
- (2011) Kyle R. Allison et al. NATURE
- Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
- (2011) Christopher B Ford et al. NATURE GENETICS
- Latent Tuberculosis Infection in the United States
- (2011) C. Robert Horsburgh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection
- (2011) Timothy R. Sterling et al. NEW ENGLAND JOURNAL OF MEDICINE
- The HtrA-Like Serine Protease PepD Interacts with and Modulates the Mycobacterium tuberculosis 35-kDa Antigen Outer Envelope Protein
- (2011) Mark J. White et al. PLoS One
- VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins
- (2011) Bintou Ahmadou Ahidjo et al. PLoS One
- CCL2/MCP-I Genotype-Phenotype Relationship in Latent Tuberculosis Infection
- (2011) Rabia Hussain et al. PLoS One
- The Role of the Novel Exopolyphosphatase MT0516 in Mycobacterium tuberculosis Drug Tolerance and Persistence
- (2011) Seema M. Thayil et al. PLoS One
- Pyrazinamide--Old TB Drug Finds New Target
- (2011) S. T. Cole SCIENCE
- Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis
- (2011) W. Shi et al. SCIENCE
- A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection
- (2011) B.-H. Kim et al. SCIENCE
- Genes and regulatory networks involved in persistence of Mycobacterium tuberculosis
- (2011) XiaoZhen Wang et al. Science China-Life Sciences
- Characterization and Transcriptome Analysis of Mycobacterium tuberculosis Persisters
- (2011) I. Keren et al. mBio
- IL-10 Blocks Phagosome Maturation inMycobacterium tuberculosis–Infected Human Macrophages
- (2010) Seónadh O'Leary et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Letting Sleeping dos Lie: Does Dormancy Play a Role in Tuberculosis?
- (2010) Michael C. Chao et al. Annual Review of Microbiology
- TNF neutralization results in disseminated disease during acute and latentM. tuberculosisinfection with normal granuloma structure
- (2010) Philana Ling Lin et al. ARTHRITIS AND RHEUMATISM
- How tumour necrosis factor blockers interfere with tuberculosis immunity
- (2010) J. Harris et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection
- (2010) Nadia Caccamo et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Transient role of CD4+CD25+ regulatory T cells in mycobacterial infection in mice
- (2010) Y. Ozeki et al. INTERNATIONAL IMMUNOLOGY
- PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosis
- (2010) W. Shi et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Regulation of Central Metabolism Genes of Mycobacterium tuberculosis by Parallel Feed-Forward Loops Controlled by Sigma Factor E ( E)
- (2010) P. Datta et al. JOURNAL OF BACTERIOLOGY
- DosS Responds to a Reduced Electron Transport System To Induce the Mycobacterium tuberculosis DosR Regulon
- (2010) R. W. Honaker et al. JOURNAL OF BACTERIOLOGY
- NoncognateMycobacterium tuberculosisToxin-Antitoxins Can Physically and Functionally Interact
- (2010) Ling Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Stringent Response Is Required for Full Virulence ofMycobacterium tuberculosisin Guinea Pigs
- (2010) Lee G. Klinkenberg et al. JOURNAL OF INFECTIOUS DISEASES
- TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: A next-generation two-compartmental model
- (2010) Simeone Marino et al. JOURNAL OF THEORETICAL BIOLOGY
- Carbon flux rerouting during Mycobacterium tuberculosis growth arrest
- (2010) Lanbo Shi et al. MOLECULAR MICROBIOLOGY
- Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway
- (2010) Rainer Kalscheuer et al. Nature Chemical Biology
- Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply
- (2010) Clifton E. Barry et al. NATURE REVIEWS MICROBIOLOGY
- Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load
- (2010) Collin R. Diedrich et al. PLoS One
- Mycobacterium tuberculosis Transcriptional Adaptation, Growth Arrest and Dormancy Phenotype Development Is Triggered by Vitamin C
- (2010) Neetu Kumra Taneja et al. PLoS One
- A Mycobacterium tuberculosis Sigma Factor Network Responds to Cell-Envelope Damage by the Promising Anti-Mycobacterial Thioridazine
- (2010) Noton K. Dutta et al. PLoS One
- Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice
- (2010) N. Dhar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection
- (2010) J. Marrero et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide
- (2010) Sheetal Gandotra et al. PLoS Pathogens
- Short-Course Therapy with Daily Rifapentine in a Murine Model of Latent Tuberculosis Infection
- (2009) Tianyu Zhang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Resuscitation-promoting Factors Reveal an Occult Population of Tubercle Bacilli in Sputum
- (2009) Galina V. Mukamolova et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective french research axed on tolerance of biotherapies registry
- (2009) F. Tubach et al. ARTHRITIS AND RHEUMATISM
- CarD Is an Essential Regulator of rRNA Transcription Required for Mycobacterium tuberculosis Persistence
- (2009) Christina L. Stallings et al. CELL
- CarD Tricks and Magic Spots: Mechanisms of Stringent Control in Mycobacteria
- (2009) Lynn E. Connolly et al. Cell Host & Microbe
- Hypoxia: a window intoMycobacterium tuberculosislatency
- (2009) Tige R. Rustad et al. CELLULAR MICROBIOLOGY
- New Vaccines Against Tuberculosis
- (2009) Paul-Henri Lambert et al. CLINICS IN CHEST MEDICINE
- The sigma factors of Mycobacterium tuberculosis: regulation of the regulators
- (2009) Preeti Sachdeva et al. FEBS Journal
- Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model
- (2009) P. L. Lin et al. INFECTION AND IMMUNITY
- The Mycobacterium tuberculosis Sigma Factor B Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth
- (2009) P. A. Fontan et al. JOURNAL OF BACTERIOLOGY
- Acid Resistance in Mycobacterium tuberculosis
- (2009) O. H. Vandal et al. JOURNAL OF BACTERIOLOGY
- The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy
- (2009) R. L. Leistikow et al. JOURNAL OF BACTERIOLOGY
- Anti-TNF immunotherapy reduces CD8+ T cell–mediated antimicrobial activity against Mycobacterium tuberculosis in humans
- (2009) Heiko Bruns et al. JOURNAL OF CLINICAL INVESTIGATION
- Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection
- (2009) J. C. J. Ray et al. JOURNAL OF IMMUNOLOGY
- Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug‐Tolerant, Not Drug‐Resistant,Mycobacterium tuberculosisin the Guinea Pig
- (2009) Zahoor Ahmad et al. JOURNAL OF INFECTIOUS DISEASES
- Phosphate Depletion: A Novel Trigger forMycobacterium tuberculosisPersistence
- (2009) Dalin Rifat et al. JOURNAL OF INFECTIOUS DISEASES
- Regulatory T Cells Modulate Th17 Responses in Patients with Positive Tuberculin Skin Test Results
- (2009) Subash Babu et al. JOURNAL OF INFECTIOUS DISEASES
- Neutralization of TNFα alters inflammation in guinea pig tuberculous pleuritis
- (2009) Lan H. Ly et al. MICROBES AND INFECTION
- Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence
- (2009) Rakesh K. Dhiman et al. MOLECULAR MICROBIOLOGY
- The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
- (2009) Mandy J McGeachy et al. NATURE IMMUNOLOGY
- A replication clock for Mycobacterium tuberculosis
- (2009) Wendy P Gill et al. NATURE MEDICINE
- The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
- (2009) Clifton E. Barry et al. NATURE REVIEWS MICROBIOLOGY
- A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen
- (2009) Chirajyoti Deb et al. PLoS One
- Salmonella Induced IL-23 and IL-1β Allow for IL-12 Production by Monocytes and Mφ1 through Induction of IFN-γ in CD56+ NK/NK-Like T Cells
- (2009) Diederik van de Wetering et al. PLoS One
- Eliminating latent tuberculosis
- (2009) Douglas B. Young et al. TRENDS IN MICROBIOLOGY
- Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution
- (2009) Holly R. Ramage et al. PLoS Genetics
- Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response
- (2009) Amit Singh et al. PLoS Pathogens
- Comparison of the Effects of Pathogenic Simian Human Immunodeficiency Virus Strains SHIV-89.6P and SHIV-KU2 in Cynomolgus Macaques
- (2008) Santosh N. Pawar et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Selective Killing of Nonreplicating Mycobacteria
- (2008) Ruslana Bryk et al. Cell Host & Microbe
- IL-23 and IL-17 in tuberculosis
- (2008) Shabaana A. Khader et al. CYTOKINE
- Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death
- (2008) Hilary Clay et al. IMMUNITY
- Role of the dosR-dosS Two-Component Regulatory System in Mycobacterium tuberculosis Virulence in Three Animal Models
- (2008) P. J. Converse et al. INFECTION AND IMMUNITY
- A Mycobacterium tuberculosis Rpf Double-Knockout Strain Exhibits Profound Defects in Reactivation from Chronic Tuberculosis and Innate Immunity Phenotypes
- (2008) E. Russell-Goldman et al. INFECTION AND IMMUNITY
- Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs
- (2008) S. D. Chakravarty et al. INFECTION AND IMMUNITY
- Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates
- (2008) L. E. Via et al. INFECTION AND IMMUNITY
- Three Mycobacterium tuberculosis Rel Toxin-Antitoxin Modules Inhibit Mycobacterial Growth and Are Expressed in Infected Human Macrophages
- (2008) S. B. Korch et al. JOURNAL OF BACTERIOLOGY
- Heme Oxygenase-1-derived Carbon Monoxide Induces theMycobacterium tuberculosisDormancy Regulon
- (2008) Ashwani Kumar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metronidazole Lacks Activity againstMycobacterium tuberculosisin an In Vivo Hypoxic Granuloma Model of Latency
- (2008) Lee G. Klinkenberg et al. JOURNAL OF INFECTIOUS DISEASES
- Early Depletion ofMycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV‐1 Infection
- (2008) Christof Geldmacher et al. JOURNAL OF INFECTIOUS DISEASES
- Tumor Necrosis Factor Blockers Influence Macrophage Responses toMycobacterium tuberculosis
- (2008) James Harris et al. JOURNAL OF INFECTIOUS DISEASES
- Tumour necrosis factor antagonists: structure, function, and tuberculosis risks
- (2008) Robert S Wallis LANCET INFECTIOUS DISEASES
- Differential fadE28 expression associated with phenotypic virulence of Mycobacterium tuberculosis
- (2008) T.H.J. Lam et al. MICROBIAL PATHOGENESIS
- Growth ofMycobacterium tuberculosisbiofilms containing free mycolic acids and harbouring drug-tolerant bacteria
- (2008) Anil K. Ojha et al. MOLECULAR MICROBIOLOGY
- The Enduring Hypoxic Response of Mycobacterium tuberculosis
- (2008) Tige R. Rustad et al. PLoS One
- Positive Feedback and Noise Activate the Stringent Response Regulator Rel in Mycobacteria
- (2008) Kamakshi Sureka et al. PLoS One
- Mycobacterial persistence requires the utilization of host cholesterol
- (2008) A. K. Pandey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tuberculosis genes expressed during persistence and reactivation in the resistant rabbit model
- (2008) Anup K. Kesavan et al. TUBERCULOSIS
- Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence
- (2008) Pascale Peyron et al. PLoS Pathogens
- A Mycobacterial Enzyme Essential for Cell Division Synergizes with Resuscitation-Promoting Factor
- (2008) Erik C. Hett et al. PLoS Pathogens
- Cytokine Profiles in Primary and Secondary Pulmonary Granulomas of Guinea Pigs with Tuberculosis
- (2007) Lan H. Ly et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndrome
- (2007) Yukari C. Manabe et al. TUBERCULOSIS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started