Testing Tuberculosis Drug Efficacy in a Zebrafish High-Throughput Translational Medicine Screen

In VivoAssessment of Drug Efficacy against Mycobacterium abscessus Using the Embryonic Zebrafish Test System

(2014) Audrey Bernut et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

(2014) V. Makarov et al.   EMBO Molecular Medicine

Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation

(2014) A. Bernut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

The emerging use of zebrafish to model metabolic disease

(2013) A. Seth et al.   Disease Models & Mechanisms

Rapid metabolic screening of early zebrafish embryogenesis based on direct infusion-nanoESI-FTMS

(2013) Robert-Jan Raterink et al.   Metabolomics

Robotic injection of zebrafish embryos for high-throughput screening in disease models

(2013) Herman P. Spaink et al.   METHODS

Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

(2013) Kevin Takaki et al.   Nature Protocols

Modulation by Cocaine of Dopamine Receptors through miRNA-133b in Zebrafish Embryos

(2012) Katherine Barreto-Valer et al.   PLoS One

Insights into tuberculosis from the zebrafish model

(2012) Russell D. Berg et al.   TRENDS IN MOLECULAR MEDICINE

An In Vivo Platform for Rapid High-Throughput Antitubercular Drug Discovery

(2012) Kevin Takaki et al.   Cell Reports

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

(2012) Tom H. M. Ottenhoff et al.   PLoS Pathogens

Zebrafish embryos and larvae: A new generation of disease models and drug screens

(2011) Shaukat Ali et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

(2011) Annemarie H. Meijer et al.   CURRENT DRUG TARGETS

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

(2011) Robert J. Young et al.   DRUG DISCOVERY TODAY

A High-Throughput Screen for Tuberculosis Progression

(2011) Ralph Carvalho et al.   PLoS One

Fast Standardized Therapeutic-Efficacy Assay for Drug Discovery against Tuberculosis

(2010) J. Rullas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos

(2010) Yan Zhou et al.   BIOMEDICAL CHROMATOGRAPHY

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

Tuberculosis: What We Don't Know Can, and Does, Hurt Us

(2010) D. G. Russell et al.   SCIENCE

Emergence of New Forms of Totally Drug-Resistant Tuberculosis Bacilli

(2009) Ali Akbar Velayati et al.   CHEST

Overcoming the global crisis: “Yes, we can”, but also for TB … ?

(2009) Tom H. M. Ottenhoff   EUROPEAN JOURNAL OF IMMUNOLOGY

Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos

(2009) Jochen Gehrig et al.   NATURE METHODS

Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery

(2008) T P Barros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS