Natural polyphenols binding to amyloid: A broad class of compounds to treat different human amyloid diseases

Type 2 Diabetes and the Aging Pancreatic Beta Cell

(2016) Uma Gunasekaran et al.   Aging-US

Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways

(2014) Johant Lakey-Beitia et al.   MOLECULAR NEUROBIOLOGY

Inhibiting toxic aggregation of amyloidogenic proteins: A therapeutic strategy for protein misfolding diseases

(2013) Biao Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

(2013) R. Ni et al.   BRAIN

Interaction between baicalein and amyloid-β fibrils studied by fluorescence spectroscopy

(2013) Sheng-mei Song et al.   CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

(2013) Massimo Stefani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis

(2013) Zhi-Yuan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model

(2013) She-Qing Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

(2013) Khushwant S. Bhullar et al.   Oxidative Medicine and Cellular Longevity

Comparision of Piceid and Resveratrol in Antioxidation and Antiproliferation Activities In Vitro

(2013) Dan Su et al.   PLoS One

Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice

(2013) Takashi Mori et al.   PLoS One

Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptideand protects pancreatic beta-cells against cytotoxicity

(2013) Biao Cheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

The role of two natural flavonoids on human amylin aggregation

(2012) Mohammad-Hossein Aarabi   African Journal of Pharmacy and Pharmacology

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide

(2012) Biao Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix

(2012) Samuel Sparks et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

(2012) James P. Solomon et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Immunopathogenesis of Neurodegenerative Diseases: Current Therapeutic Models of Neuroprotection with Special Reference to Natural Products

(2012) T. Magrone et al.   CURRENT PHARMACEUTICAL DESIGN

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease

(2012) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Natural Biomolecules and Protein Aggregation: Emerging Strategies against Amyloidogenesis

(2012) Antonella Sgarbossa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenolic Compounds Prevent Amyloid β-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding

(2012) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate

(2012) Basir Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AL Amyloidosis

(2012) Estelle Desport et al.   Orphanet Journal of Rare Diseases

Novel Role of Red Wine-Derived Polyphenols in the Prevention of Alzheimerʼs Disease Dementia and Brain Pathology: Experimental Approaches and Clinical Implications

(2012) Giulio Pasinetti   PLANTA MEDICA

A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

(2012) Robert A. Orlando et al.   PLoS One

Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers

(2012) Harris Noor et al.   PROTEIN SCIENCE

Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical

(2012) Scott D. Smid et al.   Food & Function

Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain function

(2012) David O. Kennedy et al.   Advances in Nutrition

Rottlerin dissolves pre-formed protein amyloid: A study on hen egg white lysozyme

(2011) Nandini Sarkar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Resveratrol Inhibits the Formation of Multiple-Layered β-Sheet Oligomers of the Human Islet Amyloid Polypeptide Segment 22–27

(2011) Ping Jiang et al.   BIOPHYSICAL JOURNAL

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

(2011) Mario Caruana et al.   FEBS LETTERS

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

An overview of human prion diseases

(2011) Muhammad Imran et al.   Virology Journal

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Natural polyphenols as inhibitors of amyloid aggregation. Molecular dynamics study of GNNQQNY heptapeptide decamer

(2010) Workalemahu M. Berhanu et al.   BIOPHYSICAL CHEMISTRY

The molecular basis of working mechanism of natural polyphenolic antioxidants

(2010) Monica Leopoldini et al.   FOOD CHEMISTRY

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silibinin: A novel inhibitor of Aβ aggregation

(2010) Fei Yin et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Ellagic acid promotes Aβ42 fibrillization and inhibits Aβ42-induced neurotoxicity

(2009) Ying Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Radioiodinated Aurones as Probes for SPECT Imaging of β-Amyloid Plaques in the Brain

(2009) Yoshifumi Maya et al.   BIOCONJUGATE CHEMISTRY

New stilbene dimers against amyloid fibril formation

(2009) Céline Rivière et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of curcumin on the amyloid fibrillogenesis of hen egg-white lysozyme

(2009) Steven S.-S. Wang et al.   BIOPHYSICAL CHEMISTRY

Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

(2009) P Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid-β fibrillogenesis: Structural insight and therapeutic intervention

(2009) Kevin A. DaSilva et al.   EXPERIMENTAL NEUROLOGY

Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin☆

(2009) Stefania Rigacci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Silibinin Attenuates Amyloid  25-35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor-  in Mice

(2009) P. Lu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Comparative Study of Inhibition at Multiple Stages of Amyloid-  Self-Assembly Provides Mechanistic Insight

(2009) T. J. Davis et al.   MOLECULAR PHARMACOLOGY

Dietary phenolics: chemistry, bioavailability and effects on health

(2009) Alan Crozier et al.   NATURAL PRODUCT REPORTS

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Curcumin inhibits aggregation of α-synuclein

(2008) Neeraj Pandey et al.   ACTA NEUROPATHOLOGICA

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Molecular and cellular aspects of protein misfolding and disease

(2008) Eszter Herczenik et al.   FASEB JOURNAL

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein

(2008) Dong-Pyo Hong et al.   JOURNAL OF MOLECULAR BIOLOGY

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Polyphenols as Potential Inhibitors of Amyloid Aggregation and Toxicity:Possible Significance to Alzheimers Disease

(2008) S. Bastianetto et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Polyphenol Piceid Destabilizes Preformed Amyloid Fibrils and Oligomers In Vitro: Hypothesis on Possible Molecular Mechanisms

(2008) Céline Rivière et al.   NEUROCHEMICAL RESEARCH

New polyphenols active on β-amyloid aggregation

(2007) Céline Rivière et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty

(2007) Siva Sundara Kumar Durairajan et al.   NEUROCHEMISTRY INTERNATIONAL