The PIM Family of Serine/Threonine Kinases in Cancer

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

(2015) Mayumi Naramura et al.   Oncotarget

Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor

(2015) Katriina Peltola et al.   NEOPLASIA

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

(2012) Joaquín Pastor et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells

(2012) M.-A. Hospital et al.   BLOOD

PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma

(2012) L Brault et al.   BRITISH JOURNAL OF CANCER

Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair

(2012) Jui-Ling Hsu et al.   CANCER LETTERS

The essential role of PIM kinases in sarcoma growth and bone invasion

(2012) M. Narlik-Grassow et al.   CARCINOGENESIS

Preservation of Myocardial Structure Is Enhanced by Pim-1 Engineering of Bone Marrow Cells

(2012) Pearl Quijada et al.   CIRCULATION RESEARCH

Modeling Prostate Cancer in Mice: Limitations and Opportunities

(2012) P. J. Hensley et al.   JOURNAL OF ANDROLOGY

Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound

(2012) Hirofumi Nakano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair

(2012) Sadia Mohsin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The PIM kinases in hematological cancers

(2012) Yesid Alvarado et al.   Expert Review of Hematology

7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity

(2011) Fabrice Pierre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs

(2011) Mustapha Haddach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

(2011) C. Gomez-Abad et al.   BLOOD

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

(2011) L. S. Chen et al.   BLOOD

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

(2011) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Pim Kinase Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Triggered by Bcl-2 Family Inhibitor ABT-737

(2011) J. H. Song et al.   CANCER RESEARCH

Roles of Pim-3, a novel survival kinase, in tumorigenesis

(2011) Naofumi Mukaida et al.   CANCER SCIENCE

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

(2011) D. Xu et al.   CARCINOGENESIS

Targeted cancer therapy

(2011) Jonathan H. Schatz et al.   CELL CYCLE

The Pim Kinases: New Targets for Drug Development

(2011) Ronan Swords et al.   CURRENT DRUG TARGETS

The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms

(2011) Methvin Isaac et al.   DRUG RESISTANCE UPDATES

Experimental models for the development of new medical treatments in prostate cancer

(2011) Anne Chauchereau   EUROPEAN JOURNAL OF CANCER

Overexpression of Pim-1 in bladder cancer

(2011) Shengjie Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

(2011) Jonathan H. Schatz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling

(2011) Kimberlee M. Fischer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A potential therapeutic target for FLT3-ITD AML: PIM1 kinase

(2011) Amir T. Fathi et al.   LEUKEMIA RESEARCH

The proto-oncogene Pim-1 is a target of miR-33a

(2011) M Thomas et al.   ONCOGENE

Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells

(2011) J Wang et al.   ONCOGENE

Initial testing (stage 1) of SGI-1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program

(2011) Vandana Batra et al.   PEDIATRIC BLOOD & CANCER

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

(2010) Jongchan Kim et al.   BMC CANCER

HDAC inhibitors induce cell cycle arrest, activate the apoptotic extrinsic pathway and synergize with a novel PIM inhibitor in Hodgkin lymphoma-derived cell lines

(2010) Esperanza Martín-Sánchez et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

Prognostic markers in pancreatic ductal adenocarcinomas

(2010) Aram F. Hezel et al.   CANCER BIOLOGY & THERAPY

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

(2010) Carmen Blanco-Aparicio et al.   CANCER LETTERS

Fighting Tumor Cell Survival: Advances in the Design and Evaluation of Pim Inhibitors

(2010) F. Anizon et al.   CURRENT MEDICINAL CHEMISTRY

123 Anti-tumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action

(2010) A. Barnett et al.   EJC SUPPLEMENTS

Pim kinase inhibitors: a survey of the patent literature

(2010) Tina Morwick   EXPERT OPINION ON THERAPEUTIC PATENTS

Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma

(2010) M. B. Wozniak et al.   HAEMATOLOGICA

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

Regulation of Skp2 Levels by the Pim-1 Protein Kinase

(2010) Bo Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pim-1 Regulates RANKL-Induced Osteoclastogenesis via NF- B Activation and NFATc1 Induction

(2010) K. Kim et al.   JOURNAL OF IMMUNOLOGY

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

(2010) Niina M Santio et al.   Molecular Cancer

p53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase

(2010) M. Zemskova et al.   MOLECULAR CANCER RESEARCH

PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation

(2010) M. Chang et al.   MOLECULAR CANCER THERAPEUTICS

Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

(2010) Y Wu et al.   ONCOGENE

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

(2010) J Wang et al.   ONCOGENE

The Pim protein kinases regulate energy metabolism and cell growth

(2010) Z. Beharry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pim1 Regulates Androgen-Dependent Survival Signaling in Prostate Cancer Cells

(2010) H.G. van der Poel et al.   UROLOGIA INTERNATIONALIS

Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation

(2009) Jian Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia

(2009) J. Tamburini et al.   BLOOD

PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications

(2009) Min En Nga et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Pim-3 is expressed in endothelial cells and promotes vascular tube formation

(2009) Peng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

(2009) Zhi-Fu Tao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

(2009) S. M. Mumenthaler et al.   MOLECULAR CANCER THERAPEUTICS

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

(2009) Z. Beharry et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance

(2009) J Chen et al.   ONCOGENE

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

(2009) J J Gu et al.   ONCOGENE

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA

(2009) Fang Cheng et al.   PLoS Pathogens

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

(2008) G. Wernig et al.   BLOOD

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

(2008) Weili Chen et al.   CANCER CELL

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells

(2008) Ying-Yi Li et al.   CANCER SCIENCE

Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal

(2008) Nilesh Shah et al.   EUROPEAN JOURNAL OF CANCER

The PIM1 Kinase Is a Critical Component of a Survival Pathway Activated by Docetaxel and Promotes Survival of Docetaxel-treated Prostate Cancer Cells

(2008) Marina Zemskova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer

(2008) Mohd W. Nasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma

(2008) Carol Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

(2008) Zuping Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

(2008) Eric D. Hsi et al.   LEUKEMIA & LYMPHOMA

Pim kinase-dependent inhibition of c-Myc degradation

(2008) Y Zhang et al.   ONCOGENE