The PIM kinases in hematological cancers

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

(2011) L. S. Chen et al.   BLOOD

Targeting PIM kinase activity significantly augments the efficacy of cytarabine

(2011) Kevin R. Kelly et al.   BRITISH JOURNAL OF HAEMATOLOGY

High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors

(2011) Chandrasekhar V. Miduturu et al.   CHEMISTRY & BIOLOGY

The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms

(2011) Methvin Isaac et al.   DRUG RESISTANCE UPDATES

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

(2011) Jonathan H. Schatz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

(2010) A Horiguchi et al.   BRITISH JOURNAL OF CANCER

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Environmental restrictions within tumor ecosystems select for a convergent, hypoxia-resistant phenotype of cancer stem cells

(2010) Massimo Olivotto et al.   CELL CYCLE

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation

(2010) M. Chang et al.   MOLECULAR CANCER THERAPEUTICS

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

(2010) J Wang et al.   ONCOGENE

The Pim protein kinases regulate energy metabolism and cell growth

(2010) Z. Beharry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation

(2009) Jian Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

(2009) Giorgio Cozza et al.   BIOCHEMICAL JOURNAL

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

(2009) Ron Grey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

(2009) Y.-W. Lin et al.   BLOOD

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia

(2009) J. Tamburini et al.   BLOOD

Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation

(2009) Alessio Zippo et al.   CELL

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines

(2009) Jie Li et al.   EXPERIMENTAL HEMATOLOGY

Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells

(2009) T. Akagi et al.   HAEMATOLOGICA

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode†

(2009) Kevin Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

(2009) Zhi-Fu Tao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

(2009) S. M. Mumenthaler et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

BAD: undertaker by night, candyman by day

(2009) N N Danial   ONCOGENE

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance

(2009) J Chen et al.   ONCOGENE

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

(2009) J J Gu et al.   ONCOGENE

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

(2009) Alex N. Bullock et al.   PLoS One

Mammalian Target of Rapamycin: Discovery of Rapamycin Reveals a Signaling Pathway Important for Normal and Cancer Cell Growth

(2009) James J. Gibbons et al.   SEMINARS IN ONCOLOGY

KSHV Reactivation from Latency Requires Pim-1 and Pim-3 Kinases to Inactivate the Latency-Associated Nuclear Antigen LANA

(2009) Fang Cheng et al.   PLoS Pathogens

The selectivity of inhibitors of protein kinase CK2: an update

(2008) Mario A. Pagano et al.   BIOCHEMICAL JOURNAL

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

(2008) Yunsong Tong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

(2008) G. Wernig et al.   BLOOD

IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

(2008) S. A. Didichenko et al.   BLOOD

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

(2008) Weili Chen et al.   CANCER CELL

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer

(2008) Mohd W. Nasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma

(2008) Carol Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

(2008) Eric D. Hsi et al.   LEUKEMIA & LYMPHOMA

Maximal STAT5-Induced Proliferation and Self-Renewal at Intermediate STAT5 Activity Levels

(2008) A. T. J. Wierenga et al.   MOLECULAR AND CELLULAR BIOLOGY

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1  RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

(2008) G. Niu et al.   MOLECULAR CANCER RESEARCH

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS

Pim kinase-dependent inhibition of c-Myc degradation

(2008) Y Zhang et al.   ONCOGENE

Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

(2007) R. T. Woodland et al.   BLOOD