Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

(2011) D. Xu et al.   CARCINOGENESIS

Inflammation and survival pathways: Chronic lymphocytic leukemia as a model system

(2010) Lisa S. Chen et al.   BIOCHEMICAL PHARMACOLOGY

4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

(2010) Qing-Bai She et al.   CANCER CELL

Highly Phosphorylated FOXO3A Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

(2010) S. M. Kornblau et al.   CLINICAL CANCER RESEARCH

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

(2010) Zhifu Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pim-1 Kinase Protects P-Glycoprotein from Degradation and Enables Its Glycosylation and Cell Surface Expression

(2010) Y. Xie et al.   MOLECULAR PHARMACOLOGY

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

(2010) V Iadevaia et al.   ONCOGENE

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation

(2009) G. Yoshimoto et al.   BLOOD

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

(2009) D. Schmidt-Arras et al.   BLOOD

Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia

(2009) S. Meshinchi et al.   CLINICAL CANCER RESEARCH

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

(2008) C.-J. Lin et al.   CANCER RESEARCH

Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal

(2008) Nilesh Shah et al.   EUROPEAN JOURNAL OF CANCER