Article
Engineering, Environmental
Eunike Mahayoni, Sein Min, Jongsik Kim, Keunhong Jeong, Sang Hoon Kim
Summary: In this study, sulfur-doped metal oxides were synthesized and tested for their catalytic activity in the degradation of mustard gas simulant 2CEES. The sulfur-doped mesoporous zinc oxide showed higher catalytic activity, potentially due to the involvement of cyclic sulfonium ion intermediate reaction. Optimizing the sulfur content in the catalyst layer was found to enhance the degradation efficiency of 2CEES.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Toxicology
Fanny Gros-Desormeaux, Fanny Caffin, Alexandre Igert, Nathalie Guatto, Christophe Pierard
Summary: This study compared the skin lesions induced by sulfur mustard (SM) and 2-chloroethyl ethylsulfide (CEES) and evaluated the relevance of CEES as an analog of SM. Results showed similar skin lesions with slight differences in appearance and intensity, suggesting that CEES is a suitable analog for SM.
TOXICOLOGY LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Victoria G. Snider, Rawan Alshehri, Rachel M. Slaugenhaupt, Craig L. Hill
Summary: This article presents a system for catalytic removal of the HD simulant CEES in air, using HCPs to sequester CEES and an oxidation system to catalyze its conversion to a less-toxic sulfoxide.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Environmental Sciences
Mohammad Reza Khazdair, Mohammad Hossein Boskabady
Summary: Multiple medicinal plants and natural compounds show therapeutic potential in improving lung injury induced by SM, including alleviating lung inflammation, oxidative stress, and immune responses. Clinical studies also demonstrate the effect of medicinal plants and natural compounds on respiratory symptoms, pulmonary function tests, and inflammatory markers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Medicine, General & Internal
Mohammad Reza Khazdair, Mohammad Hossein Boskabady
Summary: This review summarizes the therapeutic effects of new pharmaceutical drugs on lung injury induced by sulfur mustard exposure. Recent studies have shown that certain drugs have potential in reducing lung inflammation, oxidative stress responses, and modulating the immune system, as well as improving respiratory symptoms and pulmonary function.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Guan-chao Mao, Chu-chu Gong, Zhen Wang, Ming-xue Sun, Zhi-peng Pei, Wen-qi Meng, Jin-feng Cen, Xiao-wen He, Ying Lu, Qing-qiang Xu, Kai Xiao
Summary: The study demonstrated that BMSC-Exs could protect against SM-induced acute lung injury by promoting alveolar epithelial barrier repair, suggesting it as an alternative approach to stem cell-based therapy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Engineering, Environmental
Wenjun Jiang, Kecheng Zhu, Haonan Ma, Jinbo Liu, Chi Zhang, Yunchao Dai, Hanzhong Jia
Summary: This study investigated the formation, evolution, and types of persistent free radicals (PFRs) and reactive species (RS) on sulfur-containing microplastics (S-MPs) under simulated sunlight. Different types of PFRs were identified and characterized on the irradiated S-MPs, including oxygen-centered radicals with an adjacent S atom (thio-oxygen radicals) and sulfur-centered radicals. Reactive sulfur species (SO3•-) was also observed on irradiated S-MPs. These findings have important implications for assessing the potential risks of atmospheric S-MPs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Toxicology
Allison Fuchs, Elizabeth A. Giuliano, Nishant R. Sinha, Rajiv R. Mohan
Summary: Sulfur mustard is a chemical warfare agent that poses a threat to individuals exposed to it, causing symptoms in the respiratory system, skin, and eyes. Ocular tissues are particularly vulnerable to damage by SM, with acute, chronic, and delayed complications that are not fully understood. Various medical and surgical therapies have been studied for the ophthalmic manifestations of SM injury.
TOXICOLOGY LETTERS
(2021)
Article
Chemistry, Organic
Fei Liu, Jiapian Huang, Xinyu Wu, Feihua Du, Linghui Zeng, Jie Wu, Zhiyuan Chen
Summary: A simple and low-cost tandem sulfonylation/cyclization of 1,5-diene, aryldiazonium salt, and DABCOmiddot(SO2)2has been developed. This base-promoted multicomponent reaction provides a green and economic synthesis of sulfonylated pyrrolidones under transition-metal-free and moisture/oxygen-insensitive reaction conditions, delivering a wide range of products in moderate to high yields with excellent functional group compatibility.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Daxue Li, Weihui Wu, Hongpeng Zhang, Cheng Cheng, Bo Zhuang, Bo Zhang, Hongyi Wu, Yanhua Xiao
Summary: This study investigates the solubility of 2-chloroethyl ethyl sulfide (CEES) in nine ionic liquids (ILs) and explores the influence of IL properties on CEES solubility at the molecular level. The results show that CEES solubility depends on the physical properties of cations/anions and interactions between anions, cations, and ILs. This study provides guidance for designing ILs for dissolving CEES and improving the degradation efficiency of HD by examining cation-anion and anion/cation/IL-CEES interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Biomaterials
Siyuan Zhou, Yi Chen, Jie Xu, Yongfei Yin, Jianqing Yu, Wei Liu, Shigui Chen, Lu Wang
Summary: In this study, a supramolecular antidote to nitrogen mustard (NM) was developed by complexation of NM with carboxylatopillar[5]arene potassium salts (CP[5]AK). The results showed that CP[5]AK could effectively encapsulate NM and its toxic intermediate, providing protection against DNA and protein damage caused by NM. Both in vitro and in vivo experiments demonstrated that CP[5]AK had a good therapeutic effect on NM-induced skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Dermatology
Henry W. Lim, Indermeet Kohli, Eduardo Ruvolo, Ludger Kolbe, Iltefat H. Hamzavi
Summary: Until recently, the focus of photobiology has been on the impact of UV radiation on skin health, but the significant effects of visible light (VL) on skin have been underreported. VL can cause erythema in light-skinned individuals and pigmentary changes in dark-skinned individuals. These effects are important in dermatologic diseases and may worsen conditions aggravated by sun exposure. One driving mechanism of VL-induced skin pathologies is the induction of free radicals, which leads to melanogenesis and hyperpigmentation. Clinical studies have shown the effectiveness of topical sunscreen with antioxidants in inhibiting VL-induced erythema and reducing pigmentation. Antioxidants can help prevent the worsening of pigmentary disorders and can be incorporated into photoprotective strategies.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Chemistry, Analytical
Qiuyue Zheng, Tingting Wang, Baosheng Li, Rui Gao, Xianfa Zhang, Xiaoli Cheng, Lihua Huo, Zoltan Major, Yingming Xu
Summary: Effective detection of mustard gas is crucial for human health and public security; however, current sensors have slow response time, hindering their identification in hazardous environments. In this study, a crosslinked WO3 nanonet was synthesized on ceramic tubes using a solvothermal method. The unique structure with abundant pores facilitated charge transfer and provided adsorption sites for gas sensing. The WO3-4:1 sensor displayed an ultra-fast response time (1 s) and high response (58) towards 50 ppm 2-chloroethyl ethyl sulfide (2-CEES). A new sensing mechanism model was proposed based on characterization and testing techniques. This work provides guidance for the development of high-performance mustard gas sensors in practical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Toxicology
Ariel Gore, Tamar Kadar, Shlomit Dachir, Vered Horwitz
Summary: The use of sulfur mustard (SM) in global terrorism poses a continuing threat to both civilians and military personnel. Treatment for SM-induced ocular injury is primarily based on clinical manifestation and includes pharmaceutical and surgical interventions. Future studies may reveal additional pharmacological and biological treatments for this complex ocular injury.
TOXICOLOGY LETTERS
(2021)
Article
Plant Sciences
Badar Jahan, Noushina Iqbal, Mehar Fatma, Zebus Sehar, Asim Masood, Adriano Sofo, Ilaria D'Ippolito, Nafees A. Khan
Summary: The study showed that ethylene as ethephon is effective in alleviating the damaging effects of salt stress on mustard plants, especially when used in combination with split doses of nitrogen and sulfur treatments. The application of ethylene significantly enhanced photosynthetic efficiency, promoted the assimilation of nitrogen and sulfur, and increased antioxidant activity in the plants.
Article
Toxicology
Reena Berman, Gregory P. Downey, Azzeddine Dakhama, Brian J. Day, Hong Wei Chu
TOXICOLOGICAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Li-Ping Liang, Jennifer N. Pearson-Smith, Jie Huang, Brian J. Day, Manisha Patel
Review
Pharmacology & Pharmacy
Brian J. Day
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Brian J. Day, Preston E. Bratcher, Joshua D. Chandler, Matthew B. Kilgore, Elysia Min, John J. LiPuma, Robert J. Hondal, David P. Nichols
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Multidisciplinary Sciences
Tara B. Hendry-Hofer, Patrick C. Ng, Alison M. McGrath, David Mukai, Matthew Brenner, Sari Mahon, Joseph K. Maddry, Gerry R. Boss, Vikhyat S. Bebarta
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Li-Ping Liang, Ruth Fulton, Erica L. Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J. Day, Manisha Patel
Summary: In this study, metalloporphyrin catalytic antioxidants AEOL11207 and AEOL11114 showed significant neuroprotective effects against 6-OHDA-induced neurotoxicity in a rat model of Parkinson disease. The compounds demonstrated gastrointestinal absorption, high plasma concentrations, and ability to penetrate the blood-brain barrier, indicating their potential for disease modification in PD.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Toxicology
Reena Berman, Elysia Min, Jie Huang, Katrina Kopf, Gregory P. Downey, Kent Riemondy, Harry A. Smith, Cecile S. Rose, Max A. Seibold, Hong Wei Chu, Brian J. Day
Summary: Upon returning from deployment to Afghanistan, a substantial number of U.S. military personnel report symptoms of deploymentrelated lung disease (DRLD) believed to be caused by prolonged inhalation of toxic desert particulate matter. This study using a mouse model demonstrated that inhalation of airborne particulate matter during deployment may prime airways to be more responsive to allergen exposure after returning home, potentially due to dysregulated immune responses.
TOXICOLOGICAL SCIENCES
(2021)
Review
Chemistry, Medicinal
Reena Berman, Cecile S. Rose, Gregory P. Downey, Brian J. Day, Hong Wei Chu
Summary: Approximately 3 million US military personnel and contractors were deployed to Southwest Asia and Afghanistan over the past two decades, and many developed persistent respiratory symptoms upon returning to the US, referred to as deployment-related lung diseases (DRLD). Exposures to high levels of particulate matter are a major factor contributing to DRLD, activating lung immune and structural cells to initiate various cell signaling pathways. Understanding how airborne exposures during deployment contribute to DRLD may help identify effective targets for alleviating respiratory diseases and improving quality of life for veterans and active duty military personnel.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Pediatrics
Deborah R. Liptzin, Matthew D. McGraw, Paul R. Houin, Livia A. Veress
Summary: This study focused on CHO-associated PB patients and found that histopathological analysis of airway casts can guide treatment, with fibrinolytics and anticoagulants delivered via the airway as well as aggressive clearance measures leading to improved survival in PB patients.
PEDIATRIC PULMONOLOGY
(2022)
Article
Toxicology
Niccolette Schaunaman, Taylor Crue, Diana Cervantes, Kelly Schweitzer, Harrison Robbins, Brian J. Day, Mari Numata, Irina Petrache, Hong Wei Chu
Summary: This study investigated the effects of electronic cigarette vapor on human distal airway epithelial responses to influenza A virus infection. The results showed that pre-exposure to e-vapor increased the pro-inflammatory response in human distal airways, independently of the severity of cell injury during viral infection.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Brian J. Day, Elysia Min, Jie Huang, Chris Stanley
Summary: The innate immune response to infection can lead to inflammation and oxidative damage, and most anti-inflammatory and antioxidant therapies may further suppress the immune response. This study found that using thiocyanate as the counter anion for cationic manganese porphyrin catalytic antioxidants can enhance their antioxidant spectrum and supplement innate immunity.
Article
Biochemical Research Methods
Abigail B. Donkor, Obed A. Gyamfi, Carl W. White, Heidi J. Nick, Jacqueline S. Rioux, Livia A. Veress, Brian A. Logue
Summary: In this study, a simple and accurate method was developed to detect protein adducts formed by methyl isocyanate (MIC) in hemoglobin. The method showed excellent sensitivity, linearity, accuracy, and precision compared to existing techniques.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemistry & Molecular Biology
Hina Agraval, Taylor Crue, Niccolette Schaunaman, Mari Numata, Brian J. Day, Hong Wei Chu
Summary: The use of electronic cigarettes (ECs) is common among adolescents and young adults, but their limited knowledge about the detrimental effects on lung health is concerning. This study aimed to investigate the effects of ECs on viral infection and the release of TNF-related apoptosis-inducing ligand (TRAIL) in human lung slices. The results suggest that EC exposure amplifies viral infection and TRAIL release, highlighting the importance of appropriate TRAIL levels in controlling viral infection in EC users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Shaan Gellatly, Nicole Pavelka, Taylor Crue, Kelly S. Schweitzer, Brian J. Day, Elysia Min, Mari Numata, Dennis R. Voelker, April Scruggs, Irina Petrache, Hong Wei Chu
JOURNAL OF INFLAMMATION RESEARCH
(2020)
Review
Toxicology
Tara B. Hendry-Hofer, Patrick C. Ng, Alyssa E. Witeof, Sari B. Mahon, Matthew Brenner, Gerry R. Boss, Vikhyat S. Bebarta
JOURNAL OF MEDICAL TOXICOLOGY
(2019)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)