Article
Cell Biology
Yannic C. Bartsch, Xin Tong, Jaewon Kang, Maria Jose Avendano, Eileen F. Serrano, Tamara Garcia-Salum, Catalina Pardo-Roa, Arnoldo Riquelme, Yongfei Cai, Isabella Renzi, Guillaume Stewart-Jones, Bing Chen, Rafael A. Medina, Galit Alter
Summary: Despite evading neutralizing antibodies, the Omicron variant does not increase death rates in highly vaccinated populations, suggesting the presence of immune mechanisms beyond antibody-mediated virus neutralization. Vaccine-induced Spike protein-specific antibodies continue to drive Fc effector functions, indicating the potential of extraneutralizing antibodies in disease control.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Stefano Sganga, Silvia Riondino, Giovanni Maria Iannantuono, Roberto Rosenfeld, Mario Roselli, Francesco Torino
Summary: Antibody-drug conjugates (ADCs) are a novel type of drug that recognize, bind, and neutralize cancer cells with limited damage to normal cells. While several ADCs have been approved for cancer treatment, none have been approved for renal cell carcinoma (RCC). This paper reviews the current literature on ADCs in RCC patients and discusses potential strategies to improve their effectiveness.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Chengchao Ding, Jun He, Xiangyu Zhang, Chengcheng Jiang, Yong Sun, Yuqing Zhang, Qingqing Chen, Hongliang He, Wenting Li, Jiajia Xie, Zhirong Liu, Yong Gao
Summary: Research has found that certain key mutations in the spike protein of SARS-CoV-2 may lead to the virus evading neutralization by convalescent plasmas and monoclonal antibodies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kumpanat Pomlok, Supansa Pata, Mattapong Kulaphisit, Rachan Pangnuchar, Jiraprapa Wipasa, Duncan R. Smith, Watchara Kasinrerk, Pathrapol Lithanatudom
Summary: This study investigates the use of anti-CD147 monoclonal antibodies (mAbs) targeting CD147 in hepatocellular carcinoma (HCC) cells and reveals the induction of acute cellular swelling, activation of unfolded protein response (UPR), autophagosome accumulation, and cell cycle arrest. Unlike classic apoptosis, prolonged treatment with these mAbs leads to irreversible cell death through a non-canonical necroptotic pathway. This study provides insights into targeting CD147 in HCC and sheds light on a novel strategy to induce necroptosis as a means of killing cancer cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Terence L. Kirley, Andrew B. Norman, Kenneth D. Greis
Summary: Researchers have developed a high-affinity anti-cocaine antibody for the treatment of cocaine use disorders. They found that oxidation affects the binding of the antibody to cocaine, but excess methionine can protect the antibody from oxidation. Additionally, oxidation leads to a decrease in tryptophan fluorescence and the presence of oxidized forms of tryptophan.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Scott P. Fraser, Rustem Onkal, Margaux Theys, Frank Bosmans, Mustafa B. A. Djamgoz
Summary: The neonatal splice variant of Na(V)1.5 (nNa(V)1.5) in breast and colon cancer cells can be pharmacologically distinguished from the adult counterpart (aNa(V)1.5) by specific antibodies and toxins. This finding may contribute to the development of low molecular weight compounds as non-toxic therapeutic drugs for cancers expressing nNa(V)1.5.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ryo Ejima, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko, Yukinari Kato
Summary: CD44 is a cell surface glycoprotein with isoforms produced by alternative splicing. CD44 variant exon-containing isoforms (CD44v) are overexpressed in carcinomas, and CD44v6 predicts poor prognosis in colorectal cancer patients. CD44v6 plays important roles in CRC adhesion, proliferation, stemness, invasiveness, and chemoresistance. In this study, anti-CD44 monoclonal antibodies (mAbs) were developed and characterized for detecting CD44v6 in various applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sahana Gnanasampanthan, Andreas Kousios
Summary: Summary: Renal histopathological lesions caused by nephrotoxic monoclonal immunoglobulins produced by small B-cell or plasma cell clones that do not meet the criteria for multiple myeloma or malignant lymphoma are classified as monoclonal gammopathies of renal significance (MGRS). The review focuses on the definition, terminology, diagnostic approach, and treatment principles of MGRS from the perspective of general physicians.
Article
Biochemistry & Molecular Biology
Na Li, Qiangqiang Ge, Qiong Guo, Yuyong Tao
Summary: The Wnt pathway is a vital pathway in stem cell homeostasis and tissue regeneration, and aberrant signaling in this pathway is closely associated with cancer. Developing antibodies to block the overactivation of FZDs, the main receptors in the Wnt pathway, is a feasible option for cancer treatment. In this study, isoform-specific antibodies pF8_AC3 and sF8_AG6 were identified and shown to selectively block FZD8-mediated signaling activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Food Science & Technology
Shibei Shao, Wenhua Shang, Yuchen Bai, Leina Dou, Suxia Zhang, Jianzhong Shen, Zhanhui Wang, Kai Wen
Summary: In this study, a highly specific and high affinity monoclonal antibody 8A9 was prepared for the detection of diacetoxyscirpenol (DAS), a type A trichothecene, in rice samples. An indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and a lateral flow immunoassay (LFIA) based on the monoclonal antibody were developed, with detection limits as low as 0.65 μg/kg and 100 μg/kg, respectively. Molecular docking analysis revealed the molecular recognition mechanism of the antibody, demonstrating the highly specific recognition of DAS through hydrogen bonds and a pi-sigma bond.
Article
Virology
Wentao Shen, Qian Wang, Zhengxiang Wang, Minxuan Liu, Yingying Du, Lvfeng Yuan, Lu Han, Krzysztof Smietanka, Hualan Chen, Shuai Xu, Qiyun Zhu
Summary: The H7N9 subtype influenza A viruses pose a serious threat to public health, and there is still a lack of vaccines or drugs for humans against H7N9 influenza viruses. In this study, two monoclonal antibodies (MAbs), 4H1E8 and 7H9A6, were identified to specifically recognize and neutralize the H7N9 virus. These antibodies inhibit the conformational change of HA and block the HA-mediated membrane fusion, showing promising prophylactic and therapeutic effects against H7N9 virus infection. These findings suggest that these antibodies could be potentially used for the prevention and treatment of H7N9 influenza virus infection.
JOURNAL OF VIROLOGY
(2022)
Review
Oncology
Sabine Karam, Mohammad Haidous, Iman Abou Dalle, Amelie Dendooven, Nour Moukalled, Amaryllis Van Craenenbroeck, Ali Bazarbachi, Ben Sprangers
Summary: Monoclonal gammopathy of renal significance (MGRS) refers to a group of kidney disorders caused by a monoclonal immunoglobulin (MIg) that does not meet current hematologic criteria for therapy. MGRS-associated kidney diseases are diverse and can lead to end stage kidney disease (ESKD). Diagnosis is made through kidney biopsy and treatment should be coordinated between hematologists and nephrologists based on the type of MGRS, degree of kidney function impairment, and risk of progression to ESKD.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemical Research Methods
Brian Agnew, Shanhua Lin, Terry Zhang, Robert Aggeler, Trina Mouchahoir, John Schiel
Summary: ADCs are a rapidly growing modality for cancer treatment, which increases the complexity of analytical method development. This study utilized a specific conjugation strategy to prepare ADC mimetics, which were exhaustively characterized using high-resolution mass spectrometry-based approaches, demonstrating their utility and effectiveness in deep characterization.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Christos Damaskos, Anna Garmpi, Panagiotis Sarantis, Evangelos Koustas, Efstathios A. Antoniou, Dimitrios Dimitroulis, Gregory Kouraklis, Michail V. Karamouzis, Kleio Vrettou, Georgios Marinos, Konstantinos Kontzoglou, Nikolaos Garmpis
Summary: Unresectable hepatocellular carcinoma (HCC) is a poor-prognosis advanced primary liver malignancy. The FDA has approved several monoclonal antibodies (mAbs) including nivolumab, pembrolizumab, ramucirumab, nivolumab/ipilimumab, atezolizumab/bevacizumab, and tremelimumab/durvalumab as first- or second-line therapies for unresectable HCC. This review provides an update on the safety and efficacy of these mAbs, aiming to determine their suitability for different patient subgroups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Berfin Ozzengin, Sercan Ergun
Summary: This study aimed to investigate the relationship between the overexpression of human heparanase protein (HPSE) alternative variant protein T5 and the increased expression of miR-6814-5p in human renal cell carcinoma (RCC) cases. Results showed a significant correlation between the expression levels of miR-6814-5p and T5 with the neutrophil/lymphocyte ratio in RCC cases. These findings suggest that miR-6814-5p may play a role in the formation mechanism of T5 in RCC.
CUKUROVA MEDICAL JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
L. Koren, U. Barash, Y. Zohar, N. Karin, A. Aronheim
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Integrative & Complementary Medicine
Eran Ben-Arye, Ilana Doweck, Elad Schiff, Noah Samuels
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
(2018)
Article
Oncology
Uri Barash, Moshe Lapidot, Yaniv Zohar, Cynthia Loomis, Andre Moreira, Sari Feld, Chandra Goparaju, Haining Yang, Edward Hammond, Ganlin Zhang, Jin-Ping Li, Neta Ilan, Arnon Nagler, Harvey I. Pass, Israel Vlodavsky
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2018)
Article
Biochemistry & Molecular Biology
Ilanit Boyango, Uri Barash, Liat Fux, Inna Naroditsky, Neta Ilan, Israel Vlodavsky
Article
Oncology
Uri Barash, Moshe Lapidot, Yaniv Zohar, Cynthia Loomis, Andre Moreira, Sari Feld, Chandra Goparaju, Haining Yang, Edward Hammond, Ganlin Zhang, Jin-Ping Li, Neta Ilan, Arnon Nagler, Harvey I. Pass, Israel Vlodavsky
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2018)
Article
Nanoscience & Nanotechnology
Ravi S. Loka, Eric T. Sletten, Uri Barash, Israel Vlodaysky, Hien M. Nguyen
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Oncology
Uri Barash, Argyris Spyrou, Pei Liu, Euvgeni Vlodaysky, Chenchen Zhu, Juanjuan Luo, Dongsheng Su, Neta Ilhan, Karin Forsberg-Nilsson, Israel Vlodaysky, Xiaojun Yang
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Udayan Bhattacharya, Lilach Gutter-Kapon, Tal Kan, Ilanit Boyango, Uri Barash, Shi-Ming Yang, JingJing Liu, Miriam Gross-Cohen, Ralph D. Sanderson, Yuval Shaked, Neta Ilan, Israel Vlodavsky
Article
Chemistry, Medicinal
Emiliano Esposito, Israel Vlodavsky, Uri Barash, Giuseppe Roscilli, Ferdinando M. Milazzo, Giuseppe Giannini, Annamaria Naggi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Svenja Schwarz, Lukas Maria Gockel, Annamaria Naggi, Uri Barash, Martina Gobec, Gerd Bendas, Martin Schlesinger
Article
Oncology
Itai Margulis, Inna Naroditsky, Miriam Gross-Cohen, Neta Ilan, Israel Vlodavsky, Ilana Doweck
Summary: Activity of the endo-beta-glucuronidase heparanase, capable of cleaving heparan sulfate (HS), is often elevated in tumors, leading to increased metastasis and decreased survival rates of patients. Heparanase inhibitors are currently being tested in clinical trials for cancer treatment. Another enzyme called Hpa2 has been found to play a role in attenuating tumor growth in head and neck cancer by reducing tumor cell dissemination to lymph nodes. High levels of Hpa2 were associated with improved survival in these patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Uri Barash, Shobith Rangappa, Chakrabhavi Dhananjaya Mohan, Divakar Vishwanath, Ilanit Boyango, Basappa Basappa, Israel Vlodavsky, Kanchugarakoppal S. Rangappa
Summary: This study identified a new triazole-thiadiazole-bearing small molecule as a potent inhibitor of heparanase enzymatic activity, cell invasion, experimental metastasis, and tumor growth in mouse models. The findings provide valuable information for further research on the mode of action and clinical significance of triazolo-thiadiazoles in cancer treatment.
Article
Health Care Sciences & Services
Rana Shibli, Ofra Barnett, Zomoroda Abu-Full, Naomi Gronich, Ronza Najjar-Debbiny, Ilana Doweck, Gad Rennert, Walid Saliba
Summary: The study suggests an association between the BNT162b2 mRNA COVID-19 vaccine and an increased risk of Bell's palsy, especially in older females. However, the attributable risks are relatively small, indicating a minor impact on public health. The benefits of vaccination outweigh the potential link to Bell's palsy, which has a high recovery rate if promptly treated with corticosteroids.
LANCET REGIONAL HEALTH-EUROPE
(2021)
Review
Multidisciplinary Sciences
Chakrabhavi Dhananjaya Mohan, Swetha Hari, Habbanakuppe D. Preetham, Shobith Rangappa, Uri Barash, Neta Ilan, S. Chandra Nayak, Vijai K. Gupta, Basappa, Israel Vlodavsky, Kanchugarakoppal S. Rangappa
Article
Oncology
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa