The heparanase system and tumor metastasis: is heparanase the seed and soil?

Mutations in HPSE2 Cause Urofacial Syndrome

(2010) Sarah B. Daly et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss-of-Function Mutations in HPSE2 Cause the Autosomal Recessive Urofacial Syndrome

(2010) Junfeng Pang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cathepsin L in metastatic bone disease: therapeutic implications

(2010) Gaetano Leto et al.   BIOLOGICAL CHEMISTRY

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

(2010) A. Purushothaman et al.   BLOOD

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Heparanase Enhances Local and Systemic Osteolysis in Multiple Myeloma by Upregulating the Expression and Secretion of RANKL

(2010) Y. Yang et al.   CANCER RESEARCH

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization

(2010) Fang Wang et al.   CARDIOVASCULAR RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Post-transcriptional regulation of heparanase gene expression by a 3′ AU-rich element

(2010) Gil Arvatz et al.   FASEB JOURNAL

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Heparanase-2 Expression in Normal Ovarian Epithelium and in Benign and Malignant Ovarian Tumors

(2010) Joel Pereira de Moura et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

(2010) Flonia Levy-Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis

(2010) Thomas Kelly et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

(2010) Ken D. Johnstone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumorigenic and adhesive properties of heparanase

(2010) Flonia Levy-Adam et al.   SEMINARS IN CANCER BIOLOGY

Structure-Function Approach Identifies a COOH-Terminal Domain That Mediates Heparanase Signaling

(2009) L. Fux et al.   CANCER RESEARCH

Tumor Self-Seeding: Bidirectional Flow of Tumor Cells

(2009) Cheuk T. Leung et al.   CELL

Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma

(2009) Thais Peretti et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics

(2009) Uri Barash et al.   FASEB JOURNAL

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Heparin Enhances Serpin Inhibition of the Cysteine Protease Cathepsin L

(2009) Wayne J. Higgins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

(2009) Eyal Zcharia et al.   PLoS One

Cancer associated fibroblasts in cancer pathogenesis

(2009) Omar E. Franco et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

(2009) Masayuki Shimoda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Heparanase: busy at the cell surface

(2009) Liat Fux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5′-untranslated region

(2008) Didier Jean et al.   BIOCHEMICAL JOURNAL

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

(2008) V. Cohen-Kaplan et al.   CANCER RESEARCH

Subcellular localization of human heparanase and its alternative splice variant in COS-7 cells

(2008) Mayumi Sato et al.   CELL BIOCHEMISTRY AND FUNCTION

Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase

(2008) Ngit Shin Lai et al.   EXPERIMENTAL CELL RESEARCH

Heparanase induces VEGF C and facilitates tumor lymphangiogenesis

(2008) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF CANCER

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans

(2008) Flonia Levy-Adam et al.   PLoS One

Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung

(2008) K. Podsypanina et al.   SCIENCE

Clinical Significance of Urine Heparanase in Bladder Cancer Progression

(2008) Itay Shafat et al.   NEOPLASIA

Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88

(2007) Jon K. Fairweather et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Low and high affinity receptors mediate cellular uptake of heparanase

(2007) Olga Ben-Zaken et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Matrix metalloproteinases at cancer tumor–host interface

(2007) A NOEL et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cysteine cathepsin proteases as pharmacological targets in cancer

(2007) Carmela Palermo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES