Single-residue posttranslational modification sites at the N-terminus, C-terminus or in-between: To be or not to be exposed for enzyme access

Current Status and Future Prospects for Research on Tyrosine Sulfation

(2015) Nobuya Sasaki   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Glycyl radical activating enzymes: Structure, mechanism, and substrate interactions

(2014) Krista A. Shisler et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Modest Effects of Lipid Modifications on the Structure of Caveolin-3

(2014) Ji-Hun Kim et al.   BIOCHEMISTRY

The physiological role of reversible methionine oxidation

(2014) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

AMASS: a database for investigating protein structures

(2014) C. J. Mielke et al.   BIOINFORMATICS

Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B

(2014) Petra Van Damme et al.   BMC BIOCHEMISTRY

Transamidase subunit GAA1/GPAA1 is a M28 family metallo-peptide-synthetase that catalyzes the peptide bond formation between the substrate protein’s omega-site and the GPI lipid anchor’s phosphoethanolamine

(2014) Birgit Eisenhaber et al.   CELL CYCLE

Enzymatic mechanism of GPI anchor attachment clarified

(2014) Taroh Kinoshita   CELL CYCLE

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Holistic View on the Extended Substrate Specificities of Orthologous Granzymes

(2014) Kim Plasman et al.   JOURNAL OF PROTEOME RESEARCH

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Genesis of Tyrosine Phosphorylation

(2014) T. Hunter   Cold Spring Harbor Perspectives in Biology

PTM-SD: a database of structurally resolved and annotated posttranslational modifications in proteins

(2014) P. Craveur et al.   Database-The Journal of Biological Databases and Curation

Biological significance of complex N-glycans in plants and their impact on plant physiology

(2014) Richard Strasser   Frontiers in Plant Science

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase

(2014) Michael E. Webb et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria

(2014) Kyriakos N. Papanicolaou et al.   Frontiers in Physiology

Integrating phosphoproteomics in systems biology

(2014) Yu Liu et al.   Computational and Structural Biotechnology Journal

Class D β-Lactamases: A Reappraisal after Five Decades

(2013) David A. Leonard et al.   ACCOUNTS OF CHEMICAL RESEARCH

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase

(2013) Reema K. Thalji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein arginine methylation of non-histone proteins and its role in diseases

(2013) Han Wei et al.   CELL CYCLE

Contemporary positional proteomics strategies to study protein processing

(2013) Kim Plasman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

(2013) Marija Buljan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

(2013) Denise Wätzlich et al.   EMBO REPORTS

The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

(2013) Vladimir N. Uversky   FEBS LETTERS

Regulation of Protein Function and Signaling by Reversible CysteineS-Nitrosylation

(2013) Neal Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Redox Biochemistry of Protein Sulfenylation and Sulfinylation

(2013) Mauro Lo Conte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein glycation during aging and in cardiovascular disease

(2013) Andreas Simm   Journal of Proteomics

Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins

(2013) E. N. Leen et al.   JOURNAL OF VIROLOGY

Crystal Structure of Enterovirus 71 RNA-Dependent RNA Polymerase Complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation

(2013) C. Chen et al.   JOURNAL OF VIROLOGY

Conservation of the Extended Substrate Specificity Profiles Among Homologous Granzymes Across Species

(2013) Kim Plasman et al.   MOLECULAR & CELLULAR PROTEOMICS

Panning for phosphohistidine

(2013) Matthew J Piggott et al.   Nature Chemical Biology

A pan-specific antibody for direct detection of protein histidine phosphorylation

(2013) Jung-Min Kee et al.   Nature Chemical Biology

Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus

(2013) Takuya Ouchi et al.   Nature Chemical Biology

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

(2013) H. Christian Reinhardt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SPACER: server for predicting allosteric communication and effects of regulation

(2013) Alexander Goncearenco et al.   NUCLEIC ACIDS RESEARCH

Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications

(2013) Christian Margreitter et al.   NUCLEIC ACIDS RESEARCH

Activities at the Universal Protein Resource (UniProt)

(2013)   NUCLEIC ACIDS RESEARCH

Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation

(2013) Ligi Paul et al.   NUTRITION REVIEWS

Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction

(2013) Takamasa Teramoto et al.   Nature Communications

A Systematic Framework for Molecular Dynamics Simulations of Protein Post-Translational Modifications

(2013) Drazen Petrov et al.   PLoS Computational Biology

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

(2013) Siyang Sun et al.   eLife

Post-translational modifications induce significant yet not extreme changes to protein structure

(2012) Fuxiao Xin et al.   BIOINFORMATICS

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

(2012) Christopher W. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The 3D structure and function of digestive cathepsin L-like proteinases of Tenebrio molitor larval midgut

(2012) Daniela Beton et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of disorder in IκB-NFκB interaction

(2012) H. Jane Dyson et al.   IUBMB LIFE

Structural and Functional Characterization of Microcin C Resistance Peptidase MccF from Bacillus anthracis

(2012) Boguslaw Nocek et al.   JOURNAL OF MOLECULAR BIOLOGY

The structural basis of transferrin sequestration by transferrin-binding protein B

(2012) Charles Calmettes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures

(2012) Ian Sillitoe et al.   NUCLEIC ACIDS RESEARCH

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Protein structure as a means to triage proposed PTM sites

(2012) Elien Vandermarliere et al.   PROTEOMICS

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Allosteric post-translational modification codes

(2012) Ruth Nussinov et al.   TRENDS IN BIOCHEMICAL SCIENCES

BEWARE OF MOVING TARGETS: REFERENCE PROTEOME CONTENT FLUCTUATES SUBSTANTIALLY OVER THE YEARS

(2012) FERNANDA L. SIROTA et al.   Journal of Bioinformatics and Computational Biology

A DECADE AFTER THE FIRST FULL HUMAN GENOME SEQUENCING: WHEN WILL WE UNDERSTAND OUR OWN GENOME?

(2012) FRANK EISENHABER   Journal of Bioinformatics and Computational Biology

Melanotransferrin: Search for a function

(2011) Yohan Suryo Rahmanto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nuclear import of a lipid-modified transcription factor

(2011) Birgit Eisenhaber et al.   CELL CYCLE

Bioinformatics Analysis of aSaccharomyces cerevisiaeN-Terminal Proteome Provides Evidence of Alternative Translation Initiation and Post-Translational N-Terminal Acetylation

(2011) Kenny Helsens et al.   JOURNAL OF PROTEOME RESEARCH

Microscopic Analysis of Protein Oxidative Damage: Effect of Carbonylation on Structure, Dynamics, and Aggregability of Villin Headpiece

(2011) Drazen Petrov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1

(2011) Vitali Stanevich et al.   MOLECULAR CELL

Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å

(2011) Yasufumi Umena et al.   NATURE

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase

(2011) Abhishek Chatterjee et al.   NATURE

Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication

(2011) Simon Mitternacht et al.   PLoS Computational Biology

Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset

(2010) Fernanda L Sirota et al.   BMC GENOMICS

Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling

(2010) Wolfgang Benetka et al.   CELL CYCLE

Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-Δ-Prostaglandin J 2 Controls Coronary Hypoxic Vasodilation

(2010) Rebecca L. Charles et al.   CIRCULATION RESEARCH

Auxiliary phosphatases in two-component signal transduction

(2010) Ruth E Silversmith   CURRENT OPINION IN MICROBIOLOGY

A Proteomic and Transcriptomic Approach Reveals New Insight into β-methylthiolation ofEscherichia coliRibosomal Protein S12

(2010) Michael Brad Strader et al.   MOLECULAR & CELLULAR PROTEOMICS

A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P

(2010) Tatsuo Yanagisawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Structural Domain Mediates Attachment of Ethanolamine Phosphoglycerol to Eukaryotic Elongation Factor 1A in Trypanosoma brucei

(2010) Eva Greganova et al.   PLoS One

Bovine cytochromecoxidase structures enable O2reduction with minimization of reactive oxygens and provide a proton-pumping gate

(2010) Kazumasa Muramoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation of the Active Site Carboxy-Lysine (K70) of OXA-1 β-Lactamase Results in a Deacylation-Deficient Enzyme

(2009) Kyle D. Schneider et al.   BIOCHEMISTRY

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Phosphorylation-induced Conformational Changes in Rap1b

(2009) Martin M. Edreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational Modification of Ribosomal Proteins

(2009) Simon Arragain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Optimization of Arylamides as Inhibitors of Soluble Epoxide Hydrolase

(2009) Anne B. Eldrup et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins

(2009) Nicolas Abello et al.   JOURNAL OF PROTEOME RESEARCH

Structure and Function of the PP2A-Shugoshin Interaction

(2009) Zheng Xu et al.   MOLECULAR CELL

Location of chloride and its possible functions in oxygen-evolving photosystem II revealed by X-ray crystallography

(2009) K. Kawakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-associated farnesylated UCH-L1 promotes  -synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

(2009) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygenases Get to Grips with Polypeptides

(2009) Timothy D.H. Bugg   STRUCTURE

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase fromMethanococcus jannaschii

(2008) Erika V. Soriano et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structure of a Sulfur Carrier Protein Complex Found in the Cysteine Biosynthetic Pathway ofMycobacterium tuberculosis†‡

(2008) Christopher T. Jurgenson et al.   BIOCHEMISTRY

Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A

(2008) Yongna Xing et al.   CELL

CpcM Posttranslationally Methylates Asparagine-71/72 of Phycobiliprotein Beta Subunits in Synechococcus sp. Strain PCC 7002 and Synechocystis sp. Strain PCC 6803

(2008) G. Shen et al.   JOURNAL OF BACTERIOLOGY

Cysteine Synthase (CysM) ofMycobacterium tuberculosisIs anO-Phosphoserine Sulfhydrylase

(2008) Daniel Ågren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Protein Processing by N-terminal Proteomics Reveals Novel Species-specific Substrate Determinants of Granzyme B Orthologs

(2008) Petra Van Damme et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure and functional properties of theBacillus subtilistranscriptional repressor Rex

(2008) Ellen Wang et al.   MOLECULAR MICROBIOLOGY

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

(2008) Song Xiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli

(2008) B. P. Anton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

(2008) J. L. Vey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA