The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

The Intrinsically Disordered Tail of the Shaker Kv Channel is an Entropic Clock that Times its Binding to Scaffold Proteins

(2013) Nitzan Zandany et al.   BIOPHYSICAL JOURNAL

Kinesin tail domains are intrinsically disordered

(2013) Mark A. Seeger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure and Intrinsic Disorder in Protein Autoinhibition

(2013) Travis Trudeau et al.   STRUCTURE

Intrinsically Disordered N-Terminus of Calponin Homology-Associated Smooth Muscle Protein (CHASM) Interacts with the Calponin Homology Domain to Enable Tropomyosin Binding

(2012) Justin A. MacDonald et al.   BIOCHEMISTRY

Sweeping Away Protein Aggregation with Entropic Bristles: Intrinsically Disordered Protein Fusions Enhance Soluble Expression

(2012) Aaron A. Santner et al.   BIOCHEMISTRY

Unusual biophysics of intrinsically disordered proteins

(2012) Vladimir N. Uversky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA

(2012) Takeru Hayashi et al.   Cell Host & Microbe

Motif switches: decision-making in cell regulation

(2012) Kim Van Roey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Role of Intrinsically Disordered Regions in the Structure and Functioning of Small Heat Shock Proteins

(2012) Maria V. Sudnitsyna et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Conformational Selection and Folding-upon-binding of Intrinsically Disordered Protein CP12 Regulate Photosynthetic Enzymes Assembly

(2012) Simona Fermani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stability of the Small Nucleolar Ribonucleoprotein (snoRNP) Assembly Protein Pih1 inSaccharomyces cerevisiaeIs Modulated by Its C Terminus

(2012) Alexandr Paci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

C-terminal tail of human immunodeficiency virus gp41: functionally rich and structurally enigmatic

(2012) J. D. Steckbeck et al.   JOURNAL OF GENERAL VIROLOGY

Structural biology of cytoplasmic and axonemal dyneins

(2012) Takashi Ishikawa   JOURNAL OF STRUCTURAL BIOLOGY

The Tale of the Long Tail: the Cytoplasmic Domain of HIV-1 gp41

(2012) T. S. Postler et al.   JOURNAL OF VIROLOGY

More than just tails: intrinsic disorder in histone proteins

(2012) Zhenling Peng et al.   Molecular BioSystems

Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding

(2012) Wei-Lun Hsu et al.   PROTEIN SCIENCE

Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly

(2012) Olli Aitio et al.   STRUCTURE

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

The disordered C-terminus of the RNA Polymerase II phosphatase FCP1 is partially helical in the unbound state

(2011) Chad W. Lawrence et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Intracellular Distal Tail of the Na+/H+Exchanger NHE1 Is Intrinsically Disordered: Implications for NHE1 Trafficking

(2011) Ann-Beth Nørholm et al.   BIOCHEMISTRY

Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein

(2011) Yongqi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Intrinsically Disordered Nuclear Localization Signal and Phosphorylation Segments Distinguish the Membrane Affinity of Two Cytidylyltransferase Isoforms

(2011) Melissa K. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal Half of the cGMP Phosphodiesterase γ-Subunit Contributes to Stabilization of the GTPase-accelerating Protein Complex

(2011) Lian-Wang Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic analysis of tropomodulin/tropomyosin interactions uncovers fine-tuned binding specificity of intrinsically disordered proteins

(2011) Vladimir N. Uversky et al.   JOURNAL OF MOLECULAR RECOGNITION

Conformational Role for the C-Terminal Tail of the Intrinsically Disordered High Mobility Group A (HMGA) Chromatin Factors

(2011) Elisa Maurizio et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of Estrogen Receptor   N-Terminus Conformation and Function by Peptidyl Prolyl Isomerase Pin1

(2011) P. Rajbhandari et al.   MOLECULAR AND CELLULAR BIOLOGY

Intrinsic disorder in cell signaling and gene transcription

(2011) Agnes Tantos et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intrinsically disordered regions have specific functions in mitochondrial and nuclear proteins

(2011) Keiichi Homma et al.   Molecular BioSystems

Aromatic residues link binding and function of intrinsically disordered proteins

(2011) L. Michel Espinoza-Fonseca   Molecular BioSystems

Intrinsically disordered regions as affinity tuners in protein–DNA interactions

(2011) Dana Vuzman et al.   Molecular BioSystems

Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq

(2011) Mads Beich-Frandsen et al.   NUCLEIC ACIDS RESEARCH

Mechanism of the Interaction between the Intrinsically Disordered C-Terminus of the Pro-Apoptotic ARTS Protein and the Bir3 Domain of XIAP

(2011) Tali H. Reingewertz et al.   PLoS One

An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors

(2011) N. J. Kucera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the proteome: disordered and alternatively folded proteins

(2011) H. Jane Dyson   QUARTERLY REVIEWS OF BIOPHYSICS

The N-terminal part of Binder of SPerm 5 (BSP5), which promotes sperm capacitation in bovine species is intrinsically disordered

(2010) Prashanth Sirigeri Jois et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional dissection of the N-terminal degron of human thymidylate synthase

(2010) Sandra P. Melo et al.   BIOCHEMICAL JOURNAL

Intrinsically disordered chaperones in plants and animalsThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.

(2010) Peter Tompa et al.   Biochemistry and Cell Biology

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases

(2010) Vladimir N. Uversky   CHEMICAL REVIEWS

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

Structural Basis for Asymmetric Association of the βPIX Coiled Coil and Shank PDZ

(2010) Young Jun Im et al.   JOURNAL OF MOLECULAR BIOLOGY

Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-B

(2010) Stacy E. Dixon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How viruses hijack cell regulation

(2010) Norman E. Davey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Library of Disordered Patterns in 3D Protein Structures

(2010) Michail Yu. Lobanov et al.   PLoS Computational Biology

Close encounters of the third kind: disordered domains and the interactions of proteins

(2009) Peter Tompa et al.   BIOESSAYS

A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

(2009) Vasundhara M. Navadgi-Patil et al.   DNA REPAIR

The Intrinsically Disordered N-terminal Domain of Thymidylate Synthase Targets the Enzyme to the Ubiquitin-independent Proteasomal Degradation Pathway

(2009) Maria Marjorette O. Peña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C Terminus of the Alb3 Membrane Insertase Recruits cpSRP43 to the Thylakoid Membrane

(2009) Sebastian Falk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Helical Domains Promote Translocation of Intrinsically Disordered Polypeptides into the Endoplasmic Reticulum

(2009) Margit Miesbauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding the Atypical RA Domain of Ste50p to the Unfolded Opy2p Cytoplasmic Tail Is Essential for the High-Osmolarity Glycerol Pathway

(2009) Irena Ekiel et al.   MOLECULAR BIOLOGY OF THE CELL

Characterization of the Neuron-Specific L1-CAM Cytoplasmic Tail: Naturally Disordered in Solution It Exercises Different Binding Modes for Different Adaptor Proteins†

(2008) Sergiy Tyukhtenko et al.   BIOCHEMISTRY

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

The intramolecular chaperone-mediated protein folding

(2008) Yu-Jen Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A careful disorderliness in the proteome: Sites for interaction and targets for future therapies

(2008) Robert B. Russell et al.   FEBS LETTERS

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface

(2008) B. Marintcheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic disorder in scaffold proteins: Getting more from less

(2008) Marc S. Cortese et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES