Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement

How have alternative bearings (such as metal-on-metal, highly cross-linked polyethylene, and ceramic-on-ceramic) affected the prevention and treatment of osteolysis?

(2016) John J. Callaghan et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

What potential biologic treatments are available for osteolysis?

(2016) Edward M. Schwarz   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?

(2016) Rocky S. Tuan et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

The response of macrophages to titanium particles is determined by macrophage polarization

(2013) Jukka Pajarinen et al.   Acta Biomaterialia

The future of biologic coatings for orthopaedic implants

(2013) Stuart B. Goodman et al.   BIOMATERIALS

Macrophage polarization in response to wear particles in vitro

(2013) Joseph K Antonios et al.   Cellular & Molecular Immunology

Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles

(2013) Pushya A. Potnis et al.   CELLULAR IMMUNOLOGY

Macrophages-Key cells in the response to wear debris from joint replacements

(2013) Christophe Nich et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation

(2013) Jia Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments

(2013) X Chen et al.   Cell Death & Disease

Revision joint replacement, wear particles, and macrophage polarization

(2012) Allison J. Rao et al.   Acta Biomaterialia

Bisphosphonate Therapy for Osteoporosis: Benefits, Risks, and Drug Holiday

(2012) Michael McClung et al.   AMERICAN JOURNAL OF MEDICINE

Metal-on-metal hips: cobalt can induce an endotoxin-like response

(2012) Alison Jane Tyson-Capper et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss

(2012) Emmanuel Gibon et al.   BIOMATERIALS

Modification of Decoy Oligodeoxynucleotides to Achieve the Stability and Therapeutic Efficacy

(2012) Mariana Kiomy Osako et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Combination gene therapy targeting on interleukin-1β and RANKL for wear debris-induced aseptic loosening

(2012) H Wang et al.   GENE THERAPY

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

(2012) Jiri Gallo et al.   Innate Immunity

Modulation of macrophage activation and programming in immunity

(2012) Guangwei Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Inhibitory effects of recombinant IL-4 and recombinant IL-13 on UHMWPE-induced bone destruction in the murine air pouch model

(2012) Yang Wang et al.   JOURNAL OF SURGICAL RESEARCH

Safety of Bisphosphonates

(2012) Catalina Orozco et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Exogenous MC3T3 Preosteoblasts Migrate Systemically and Mitigate the Adverse Effects of Wear Particles

(2012) Kate Fritton et al.   TISSUE ENGINEERING PART A

Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles

(2011) Jeremy I. Pearl et al.   BIOMATERIALS

Therapeutic Potential of the Proteasome Inhibitor Bortezomib on Titanium Particle-Induced Inflammation in a Murine Model

(2011) Xin Mao et al.   INFLAMMATION

Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles

(2011) Emmanuel Gibon et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Evaluation of Osteoclastogenesis via NFκB Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages

(2011) Thuy Duong Dinh et al.   PHARMACEUTICAL RESEARCH

Cellular chemotaxis induced by wear particles from joint replacements

(2010) Stuart B. Goodman et al.   BIOMATERIALS

Continuous Infusion of UHMWPE Particles Induces Increased Bone Macrophages and Osteolysis

(2010) Pei-Gen Ren et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Bacterial Pathogen-associated Molecular Patterns Stimulate Biological Activity of Orthopaedic Wear Particles by Activating Cognate Toll-like Receptors

(2010) Edward M. Greenfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

New Treatment of Periodontal Diseases by Using NF-κB Decoy Oligodeoxynucleotides via Prevention of Bone Resorption and Promotion of Wound Healing

(2009) Hideo Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Orchestration of macrophage polarization

(2009) A. Mantovani et al.   BLOOD

Gene Therapy Targeting Nuclear Factor-κB: Towards Clinical Application in Inflammatory Diseases and Cancer

(2009) Sander Tas et al.   CURRENT GENE THERAPY

Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor

(2009) So Young Kim et al.   IMMUNOLOGY

Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation

(2009) Kai Zhang et al.   INFLAMMATION RESEARCH

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Inhibition of osteoblastic bone formation by nuclear factor-κB

(2009) Jia Chang et al.   NATURE MEDICINE

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

An in vivo murine model of continuous intramedullary infusion of polyethylene particles

(2008) Ting Ma et al.   BIOMATERIALS

Systemic trafficking of macrophages induced by bone cement particles in nude mice

(2008) Pei-Gen Ren et al.   BIOMATERIALS

Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NF B and E2F in a rabbit model

(2008) T. Miyake et al.   CARDIOVASCULAR RESEARCH

Biocompatibility of total joint replacements: A review

(2008) Stuart B. Goodman et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

In vivomurine model of continuous intramedullary infusion of particles-A preliminary study

(2008) Ting Ma et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Immunogenecity of Modified Alkane Polymers Is Mediated through TLR1/2 Activation

(2008) Radhashree Maitra et al.   PLoS One

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis

(2007) Panagiotis Koulouvaris et al.   JOURNAL OF ORTHOPAEDIC RESEARCH