Bacterial Pathogen-associated Molecular Patterns Stimulate Biological Activity of Orthopaedic Wear Particles by Activating Cognate Toll-like Receptors

What other biologic and mechanical factors might contribute to osteolysis?

(2016) Ed M. Greenfield et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

How prevalent are implant wear and osteolysis, and how has the scope of osteolysis changed since 2000?

(2016) Amanda Marshall et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased Expression of Toll-like Receptors in Aseptic Loose Periprosthetic Tissues and Septic Synovial Membranes Around Total Hip Implants

(2009) Y. TAMAKI et al.   JOURNAL OF RHEUMATOLOGY

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

(2009) Radhashree Maitra et al.   MOLECULAR IMMUNOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

Osteoimmunology: Interactions of the Bone and Immune System

(2008) Joseph Lorenzo et al.   ENDOCRINE REVIEWS

Presentation of lipoteichoic acid potentiates its inflammatory activity

(2008) Susanne Deininger et al.   IMMUNOBIOLOGY

Stimulation of macrophage TNFα production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-κB pathways but is independent of p38 and JNK

(2008) Michelle A. Beidelschies et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

(2008) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Immunogenecity of Modified Alkane Polymers Is Mediated through TLR1/2 Activation

(2008) Radhashree Maitra et al.   PLoS One

The local inflammatory environment and microorganisms in “aseptic” loosening of hip prostheses

(2007) Caroline S. M. Hoenders et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS