Article
Pharmacology & Pharmacy
Juan Duan, Xuantao Hu, Tao Li, Gen Wu, Pengcheng Dou, Zhengxiao Ouyang
Summary: The study demonstrates that CIM has the potential to inhibit RANKL-induced osteoclastogenesis by suppressing the NF-kappa B signaling pathway in vitro, and prevent periprosthetic osteolysis in vivo. These findings suggest the therapeutic potential of CIM in the treatment of ALP.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jian Yin, Zhaoyang Yin, Peng Lai, Xinhui Liu, Jinzhong Ma
Summary: This review examines the pathological process of periprosthetic osteolysis (PPO) and the molecular mechanism of pyroptosis, discussing interventions to inhibit inflammation and pyroptosis. The study provides theoretical support for finding new strategies and targets for the treatment of PPO.
Article
Biochemistry & Molecular Biology
He Zhang, Ying Kang, Xinyi Qi, Jingshuai Wu, Dong Liu, Aili Fan, Jian Huang, Wenhan Lin
Summary: This study identified a new cyclopeptide, versicotide G (VG), through chemical and bioassay examinations. VG demonstrated the ability to suppress the formation and function of osteoclasts, suggesting its potential as a therapeutic candidate for bone destruction-related diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Huidong Wang, Xiankun Cao, Jiadong Guo, Xiao Yang, Xiaojiang Sun, Zhiyi Fu, An Qin, Yujie Wu, Jie Zhao
Summary: The artificially synthesized compound BNTA has antioxidant and anti-inflammatory properties, and can effectively inhibit the activation and overproliferation of osteoclasts, reducing bone resorption. It may be a potential drug for preventing inflammatory osteolytic bone diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Zhaoyang Yin, Ge Gong, Xiang Wang, Wei Liu, Bin Wang, Jian Yin
Summary: Periprosthetic osteolysis (PPO) induced by wear particles is a significant cause of aseptic loosening after joint replacement, and the imbalance of osteogenesis and osteoclastic processes plays a central role. The cells involved in PPO include osteoclasts, osteoblasts, osteocytes, and fibroblasts. The RANKL/RANK/OGP axis is a typical pathway for osteolysis. Autophagy has a dual role in PPO, regulating inflammatory cytokine release, osteoclast activation, and osteoblast differentiation, but its beneficial or detrimental effects are controversial. This article focuses on the role of autophagy in PPO and highlights its potential as a target for clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Yongxian Li, Sipeng Lin, Panjie Liu, Jianbin Huang, Junxiong Qiu, Zhenkang Wen, Jinbo Yuan, Heng Qiu, Yuhao Liu, Qian Liu, Tengpeng Zhou, Peijie Luo, Huizhi Guo, Yanhuai Ma, Danqing Guo, Guoye Mo, Yongchao Tang, Liangliang Xu, De Liang, Jiake Xu, Yue Ding, Shuncong Zhang
Summary: The study found that Carnosol has a strong inhibitory effect on osteoclast differentiation induced by RANKL, potentially serving as a therapeutic supplementary in the prevention or treatment of osteolysis by suppressing the formation and function of RANKL-induced osteoclasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Qianli Huang, Jia Wan, Zhengxiao Ouyang, Tao Li, Dapeng Zhao, Hong Wu, Tang Liu, Wei Zhang, Luxin Liang
Summary: In this study, spherical Ti and Ta particles with similar sizes were used to mimic wear debris. It was found that Ta particles had a naturally formed oxide layer on their surfaces, with more hydroxyls and lower zeta potential. In vitro experiments showed that Ta particles had milder effects on osteoblast, macrophage, and osteoclast response compared to Ti particles. Additionally, the in vivo osteolytic effect of Ta particles was weaker than that of Ti particles after injection into the cranial sites of mice for 2 weeks.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Linke Huang, Weiwei Chen, Linhua Wei, Yuangang Su, Jiamin Liang, Haoyu Lian, Hui Wang, Feng Long, Fan Yang, Shiyao Gao, Zhen Tan, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: This study investigated the effects and mechanisms of the farnesyltransferase inhibitor Lonafarnib (Lon) on osteoclasts and its role in titanium particle-induced osteolysis. The results showed that Lon suppressed bone resorption and osteoclastogenesis, reduced pro-inflammatory substances production, and prevented osteolysis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhiping Zhao, Changyao Wang, Yingxing Xu, Xiangyu Wang, Bin Jia, Tengbo Yu, Yingzhen Wang, Yongtao Zhang
Summary: Wear particles can induce periprosthetic osteolysis and aseptic loosening, with local bone RAS playing a role in regulating bone resorption and formation. Inhibition of RAS may be a potential approach for the treatment of wear-particle-induced PPOL, as suggested by experimental findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Minghui Gu, Baiqi Pan, Weishen Chen, Hai Xu, Xiaoyu Wu, Xuantao Hu, Linli Zheng, Yongyu Ye, Qing Meng, Guoyan Xian, Ziji Zhang, Puyi Sheng
Summary: In this study, we found that SPHK inhibitors (ABC294640 and FTY720) combined with ZA decreased the degree of inflammatory osteolysis in vivo. However, ABC294640 and ZA suppressed osteoclast differentiation and osteoclast-specific genes in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mingchao Jin, Jiangbo Nie, Juli Zhu, Jing Li, Tianshun Fang, Juntao Xu, Xuesheng Jiang, Zhuo Chen, Jianyou Li, Fengfeng Wu
Summary: This study demonstrated for the first time that acacetin inhibited osteoclastogenesis, bone resorption activity, and related gene expression by modulating multiple signaling pathways, suggesting its potential therapeutic effects for preventing osteoporosis and other osteolytic disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Isidora Panez-Toro, Dominique Heymann, Francois Gouin, Jerome Amiaud, Marie-Francoise Heymann, Luis A. Cordova
Summary: This review discusses the role of non-myelomonocytic cells in periprosthetic tissues exposed to wear particles. T cells and B cells are found to coexist with multinucleated giant cells in periprosthetic membranes infiltrated by polyethylene and metallic particles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Victoria C. C. Brom, Andreas C. C. Strauss, Alexander Sieberath, Jochen Salber, Christof Burger, Dieter C. C. Wirtz, Frank A. A. Schildberg
Summary: Immune checkpoint inhibitors have been extensively researched in cancer treatment, but they often provoke auto-inflammatory reactions and have a significant effect on bone-resorbing cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yunfei He, Dongdong Cheng, Cheng Lian, Yingjie Liu, Wenqian Luo, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Xue Zhang, Zhen Pan, Jinxi Lu, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Qingcheng Yang, Guohong Hu
Summary: In the context of giant cell tumor of bone, the proteoglycan Serglycin secreted by neoplastic stromal cells plays a crucial role in the formation of multinucleated giant cells and tumorigenesis. Through interaction with CD44 on the surface of monocytes, SRGN promotes osteoclast differentiation. Targeting CD44 may provide a new therapeutic approach for GCTB.
CELL DEATH & DISEASE
(2021)
Article
Integrative & Complementary Medicine
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi
Summary: The study found that alpha-mangostin can inhibit the formation and function of osteoclasts and prevent inflammatory osteolysis by inhibiting the activation of the NF-kappa B/mitogen-activated protein kinase signaling pathways. This has potential clinical applications for treating osteoclast-related diseases.
Article
Materials Science, Multidisciplinary
Aybala Usta, Ka P. Man, Nora Strong, Heath Misak, Paul H. Wooley, Ramazan Asmatulu
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2020)
Article
Chemistry, Physical
Nathan Drummond, Bradley W. Bruner, Michael H. Heggeness, Bradley Dart, Shang-You Yang
Article
Cell Biology
HongFei Xiang, WeiLiang Su, XiaoLin Wu, WuJun Chen, WenBin Cong, Shuai Yang, Chang Liu, ChenSheng Qiu, Shang-You Yang, Yan Wang, GuoQing Zhang, Zhu Guo, DongMing Xing, BoHua Chen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Orthopedics
Wenzhao Wang, Liang Ma, Jun Li, Shang-You Yang, Zheng Yi, Mingjie Sun, Jianan Chen, Wei Xie
Summary: This study identified differentially expressed lncRNAs in the lesion epicenter of spinal tissues following traumatic SCI, and predicted potential regulatory networks using high-throughput sequencing and bioinformatics analysis. The findings contribute to a better understanding of the mechanisms underlying subacute SCI, highlighting the involvement of lncRNAs in regulating multiple pathways in pathophysiological processes. Further research is needed to reveal the exact mechanisms of competing endogenous RNA pathways in vivo and in vitro.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Cell Biology
Xiaolin Wu, Chang Liu, Shuai Yang, Nana Shen, Yan Wang, Youfu Zhu, Zhaoyang Guo, Shang-you Yang, Dongming Xing, Houxi Li, Zhu Guo, Bohua Chen, Hongfei Xiang
Summary: The study utilized omics analysis and mass spectrometry techniques to identify a series of metabolic pathways associated with the Gly-Ser-Thr metabolic axis that affect carbohydrate patterns and energy utilization efficiency, ultimately delaying intervertebral disc degeneration through antioxidant effects.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Zhu Guo, WeiLiang Su, RongYao Zhou, GuoQing Zhang, Shuai Yang, XiaoLin Wu, ChenSheng Qiu, WenBin Cong, Nana Shen, JianWei Guo, Chang Liu, Shang-You Yang, DongMing Xing, Yan Wang, BoHua Chen, HongFei Xiang
Summary: The study found that human urine-derived stem cell exosomes (USC-exos) could promote nucleus pulposus cell (NPC) proliferation and extracellular matrix (ECM) synthesis by transferring the MATN3 protein, potentially playing a role in alleviating intervertebral disc degeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Clinical Neurology
Nana Shen, Xiaolin Wu, Zhu Guo, Shuai Yang, Chang Liu, Zhaoyang Guo, Shang-You Yang, Dongming Xing, Bohua Chen, Hongfei Xiang
Summary: This study introduces a treatment-oriented fracture classification method for cervical spine fractures in patients with ankylosing spondylitis and evaluates its clinical efficacy. The classification and selection of surgical treatment methods were based on the evaluation of three main types and four subtypes of cervical spine fractures.
PAIN RESEARCH & MANAGEMENT
(2022)
Article
Oncology
Lin Shen, Han Li, Ronghan Liu, Chendan Zhou, Morgan Bretches, Xuan Gong, Laitong Lu, Ying Zhang, Kai Zhao, Bin Ning, Shang-You Yang, Aijun Zhang
Summary: This study aims to elucidate the critical role of DEPDC1, a tumor-related gene, in the progression of osteosarcoma. It was found that DEPDC1 is highly expressed in human osteosarcoma cells and tumor tissue, and its silencing can inhibit cell proliferation, promote apoptosis, and prevent tumor metastasis. Clinical analysis also showed a correlation between overexpression of DEPDC1 and reduced patient survival rate. This study suggests that targeting or inhibiting DEPDC1 may be a promising strategy for treating human osteosarcoma.
Article
Endocrinology & Metabolism
Hui Dong, Ronghan Liu, Ke Zou, Zhengxin Jin, Jianning Kang, Ying Zhang, Xiaodi Zhang, Zhengfang Sun, Guilian Yu, Nana Huang, Morgan Bretches, Shang-You Yang, Bin Ning
Summary: Osteoporosis, a common bone disease, can be treated by higenamine (HG), a small-molecule compound that promotes bone formation through the SMAD2/3 pathway. In vitro experiments showed that HG induced expressions of osteogenic markers in mouse bone marrow stromal cell (BMSCs) and preosteoblastic cell cultures, while in vivo experiments on animal models confirmed enhanced bone formation and prevented bone loss. IQGAP1 was identified as a novel target of HG, and HG exerted its osteogenic effects by binding to the Glu-1019 site of IQGAP1 and promoting SMAD2/3 phosphorylation while inhibiting SMAD4 ubiquitination.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Clinical Neurology
Zhaoyang Guo, Yuanye Ma, Yaqing Wang, Hongfei Xiang, Shang -You Yang, Zhu Guo, Ronghuan Wang, Wujun Chen, Dongming Xing, Bohua Chen, Hao Tao, Xiaolin Wu
Summary: This study investigates the relationship between IL-6 and TMEM100 in discogenic low back pain. Metabolomic analysis reveals that TMEM100 expression change is associated with the metabolic axis of Gly-Ser-Thr and plays a significant role in relieving discogenic pain.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jianhua Ge, Ramazan Asmatulu, Bo Zhu, Qiu Zhang, Shang-You Yang
Summary: This study characterized novel magnetic scaffolds that can be used as a central station to regulate the drug delivery of a magnetic nanoparticle system. The scaffolds exhibited magnetic, mechanical, and biological properties, with higher mechanical performances observed in scaffolds with a micron-sized Fe3O4 to PCL weight ratio of 0.1:0.9.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Renyi Sun, Tanghong Jia, Bradley Dart, Sunaina Shrestha, Morgan Bretches, Michael H. Heggeness, Shang-You Yang
Summary: A population of cells within human peripheral nerves has been identified that display pluripotency potential and can differentiate into various cell types when exposed to specific stimuli. These cells, similar to rodent NEDAPS cells, respond to BMP-2 and express multiple transcription factors, suggesting a previously unknown natural mechanism for healing injuries in peripheral nerves.
BIOENGINEERING-BASEL
(2021)
Proceedings Paper
Engineering, Biomedical
Shang-You Yang, Yuan-Pin Lin
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
(2020)
Article
Medicine, General & Internal
Nathaniel Parker, Nora Strong, Pie Pichetsurnthorn, Daniel Lalich, Thomas Moore
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Polymer Science
Anil Mahapatro, Kayla Jensen, Shang-You Yang
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2020)